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Principal Investigator: Stiell, Ian (Ottawa Hospital Research Institute).
This application is a proposal to create a collaborative Canadian Regional Clinical Center (RCC), with two major partners: the University of Ottawa/OPALS Study Group and the University of British Columbia (UBC) Group. The overall goal is to continue to conduct large resuscitation clinical trials that will improve the outcomes of victims of cardiopulmonary arrest and major trauma.
As a major partner, the collaborative Canadian RCC is committed to achieving all objectives of the Consortium with regards to cardiopulmonary arrest and major trauma:
- conduct large, collaborative clinical trials to evaluate interventions that will improve survival;
- strengthen existing research infrastructure in Ottawa/OPALS and UBC Groups;
- produce methodologically robust research proposals;
- strengthen and further develop regional and national cardiopulmonary arrest and trauma registries;
- support potential emerging sites for resuscitation research in Canada (Calgary, Edmonton, and Nova Scotia);
- facilitate the training of clinical researchers in resuscitation and emergency medicine through a Clinical Research Skills Development Core.
In particular, the proposed collaborative Canadian RCC has designed two specific resuscitation randomized controlled clinical trials:
- A comparison of fixed versus escalating energy regiments for biphasic waveform defibrillation. This trial will compare the effect of fixed low-energy (150 joules) to escalating energy (200-300-360 joules) regiment on clinical outcomes of out-of-hospital cardiopulmonary arrest patients.
Pre-hospital intubation and ventilation control in blunt head injury. This trial will compare pre-hospital mandatory rapid sequence intubation followed by controlled ventilation to standard airway management in trauma patients with head injury and decreased level of consciousness.