Regenerative Medicine and Nanomedicine: Innovative Approaches in Health Research - Competition Results 2004

The overarching goal of this strategic initiative is to encourage the development of truly multi-disciplinary research approaches to dealing with regenerative medicine and nanomedicine. This includes identifying the social, cultural and ethical impacts of these novel technologies, as well as accessibility issues and the potential economic costs of such treatments. Regenerative medicine is an emerging field that seeks to repair or replace injured tissues and organs through natural or bioengineered means. Nanomedicine is the specialized biomedical measurement or intervention at a molecular or cellular scale for treating diseases or repairing damaged tissues. This strategic initiative also seeks to encourage young researchers to enter these fields and to develop a multi-disciplinary perspective. This will require the close collaboration and integration of the physical, engineering, computational and chemical sciences with the biosciences and social sciences.

The June 2003 RFA in Regenerative Medicine and Nanomedicine was a strategic cross-cutting initiative led by the CIHR Institute of Neurosciences, Mental Health and Addiction and the Institute of Genetics in partnership with: Institute of Cancer Research, Institute of Circulatory and Respiratory Health, Institute of Infection and Immunity, Institute of Musculoskeletal Health and Arthritis, Canadian Stroke Network, Heart and Stroke Foundation of Canada, Juvenile Diabetes Research Foundation International, National Research Council Canada, Natural Sciences and Engineering Research Council of Canada, Neuroscience Canada Partnership, Ontario Neurotrauma Foundation and the Stem Cell Network.
 
The June 2003 RFA offered support for innovative research projects in the areas of Nanotechnology Development and Nanomedicine, Stem Cells, and Tissue Engineering. This support was provided through innovative Pilot Project Grants, New Emerging Teams (NET) Grants, and Interdisciplinary Capacity Enhancement (ICE) Teams Grants.
 
For information on the June 2004 re-launch of the RFA in Regenerative Medicine and Nanomedicine, please see: Regenerative Medicine and Nanomedicine: Innovative Approaches in Health Research.
 

Pilot Project Grants

Pilot Project Grants support innovative, high risk, pilot or feasibility research in the areas of Nanomedicine, Stem Cells, and Tissue Engineering. Grants will allow investigators with novel ideas and observations to conduct pilot studies and/or gather evidence necessary to determine the viability of new research directions. It is anticipated that applicants who validate their pilot hypotheses will then continue their research by applying to regular funding opportunities.
 

New Emerging Team (NET) Grants

New Emerging Team grants are intended to support the creation or development of teams comprised of investigators undertaking collaborative, multidisciplinary research. The program is intended to promote the formation of new and previously nonexistent research teams or the growth of small existing teams of researchers in the areas of Nanomedicine, Stem Cells, and Tissue Engineering.
 

Interdisciplinary Capacity Enhancement Grants

Interdisciplinary Capacity Enhancement (ICE) Team grants are intended to provide support for new or existing groups conducting multi-disciplinary research on themes that align with this strategic initiative in the areas of Nanomedicine, Stem Cells, and Tissue Engineering. The grants will enable teams to build capacity and add expertise to their core capacities and develop strategies for knowledge translation.
 
The applications approved for funding through the Regenerative Medicine and Nanomedicine: Innovative Approaches in Health Research competitions are listed below.
 

Results of the Strategic Initiative

  • Pilot Projects - 8 Applications Received; 5 Approved
  • New Emerging Team (NET) Grants - 16 Applications Received; 8 Approved
  • Interdisciplinary Capacity Enhancement (ICE) Team - 1 Application Received; 0 Approved

Pilot Projects

  • BENNETT, Stephanie (University of Ottawa)
    Co-Applicant(s): BROWN, Earl
    Reovirus-mediated gene delivery to adult neural stem cells
    $60,000 1 year
    Funded by: Institute of Neurosciences, Mental Health and Addiction (INMHA)
     
  • CALON, Frederic (Centre Hospitalier de l'Université Laval)
    Non-invasive brain delivery of glial-derived neurotrophic factor gene using immunoliposomal nanocontainers
    $60,000 1 year 
    Funded by: Institute of Neurosciences, Mental Health and Addiction (INMHA)
     
  • HEBERT, Marie-Josée (Centre Hospitalier de l'Université de Montréal)
    Co-Applicant(s): LEROUGE, Sophie / SOULEZ, Gilles
    Development of aortic stent grafts that forster aortic repair: Mimicking the normal vascular healing process with increased production of a C-terminal fragment of perlecan
    $60,000 1 year
    Funded by: Institute of Circulatory and Respiratory Health (ICRH)
     
  • PUTNINS, Edward (University of British Columbia)
    Co-Applicant(s): ROSSI, Fabio
    Regeneration of hard & soft periodontal connective tissues utilizing engineered mesenchymal stem cells
    $60,000 1 year
    Funded by:Institute of Musculoskeletal Health and Arthritis (IMHA)
     
  • WOODHOUSE, Kimberly (University of Toronto)
    Co-Applicant(s): SANTERRE, Paul
    Surfacing modifying molecules based on recombinant human elastin polypeptides: A novel material for regenerative medicine applications in the vasculature
    $60,000 1 year
    Funded by: Institute of Circulatory and Respiratory Health (ICRH)

New Emerging Team Grants

  • BRUNETTE, Isabelle (Université de Montréal)
    Co-Applicant(s): KIEFFER, Jean-Claude / ELEZZABI, Abdulhakem / GERMAIN, Lucie / AUBIN, Marie-Josée / LACHAINE, Jean
    Femtosecond Laser Assisted Corneal Posterior Lamellar Transplantation with Endothelial Enhancement: Technological Development and Socioeconomic Impact
    $300,000 5 years
    Funded by: CIHR / Institute of Genetics (IG) / Institute of Neurosciences, Mental Health and Addiction (INMHA)
     
  • CHAN, Warren (University of Toronto)
    Co-Applicant(s): WILSON, Brian / WEERSINK, Robert / GUINDI, Maha / SEFTON, Michael / TSAO, Ming / WANG, Chen / PANG, Kim-Ching Sandy
    Quantum dot-based biomolecular imaging
    $300,000 5 years
    Funded by: CIHR / Institute of Genetics (IG)
     
  • DAAR, Abdallah (University of Toronto) Co-Applicant(s): GODARD, Béatrice / GOLD, Edward / EINSIEDEL, Edna / KNOPPERS, Bartha / SINGER, Peter / CASTLE, David / CAULFIELD, Timothy / DUVAL, Gordon / ZLOTNIK SHAUL, Randi / STEWART, Duncan
    Regenerative Medicine: Ethical, Environmental, Economic, Legal and Social Issues Network
    $300,000 5 years
    Funded by: CIHR / Institutes of Genetics (IG) / Institute of Circulatory and Respiratory Health (ICRH)
     
  • DE KONINCK, Yves (Centre de recherche Université Laval)
    Co-Applicant(s): GRUTTER, Peter / Lennox, r. Bruce / WISEMAN, Paul / BEHRENDS, Jan / DE KONINCK, Paul
    Nanotools for Neuropharmacology
    $300,000 5 years
    Funded by: CIHR / Institute of Neurosciences, Mental Health and Addiction (INMHA) / Institute of Genetics (IG)
     
  • FEHLINGS, Michael (University of Toronto) Co-Applicant(s): MORSHEAD, Cindi / SOICHET, Molly / TATOR, Charles / VAN DER KOOY, Derek / STANISZ, Gret Regenerative medicine strategies for spinal cord injury repair: Integration of stem cell biology, nanotechnology, bioengineering approaches and neurosurgical application
    $300,000 5 years
    Funded by: CIHR / Institutes of Neurosciences, Mental Health and Addiction (INMHA) / Institute of Genetics (IG)
     
  • GALIPEAU, Jacques (McGill University)
    Co-Applicant(s): LIU, Peter / STEWART, Duncan / LANSDORP, Peter / KARSAN, Aly / MEGENEY, Lynn Cardiovascular and respiratory stem cell plasticity - CARE project
    $299,900 5 yearsFunded by: Institute of Circulatory and Respiratory Health (ICRH)/ Heart and Stroke Foundation of Canada (HSFC) / Stem Cell Network (SCN)
     
  • RIVEST, Serge (Université Laval)
    Co-Applicant(s): JULIEN, Jean-Pierre / VALLIERES, Luc / LACROIX, Steve / KRIZ, Jasna
    Engineered bone marrow stem cells (BMSCs) for treatment of CNS injuries and disease
    $300,000 5 years
    Funded by: CIHR / Institute of Neurosciences, Mental Health and Addiction (INMHA)/ Institute of Circulatory and Respiratory Health (ICRH)
     
  • STANFORD, William (University of Toronto)
    Co-Applicant(s): AUDET, Julie / CHAN, Warren / ISCOVE, Norman / KUMACHEV, Eugenia / VAN DER KOOY, Derek / YIP, Christopher / ZANDSTRA, Peter
    Stem cell fate analysis and manipulation
    $300,000 5 years
    Funded by: CIHR / Institute of Genetics (IG)

     

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