Heart and Stroke Foundation of Ontario

Results of September 2004 Grant-in-Aid and Career Investigator Competitions

The Heart and Stroke Foundation of Ontario is pleased to announce the scientists from Ontario who were awarded Grant-in-Aid / Career Investigator funding in the September 2004 competition.

These results posted below are to be considered preliminary only. An official letter will be sent to all applicants the week of March 14, 2005, along with the budget / funding details and rankings. Career Investigator awards do not have first year amounts, however the standard stipend applies.

For those awards identified as "pending", funding is encumbered until additional information is provided. Applicants will be contacted in the near future in this regard. Some proposals were not ranked high enough to receive full funding. In such cases, the Foundation has provided a terminal award, in order to assist scientists in maintaining some level of research activity until a re-application can be made.

The Foundation requests that you do not write or telephone with any enquiries before receiving the award letters.

Adams, Michael A. (Queen's University)

Antihypertensive treatment strategies in the management of sexual dysfunction

TYPE 3 Year
New
(pending)		 $130,413

Adams, Michael A. (Queen's University)

Antihypertensive drug-induced persistent lowering of pressure

TYPE 2 Year
New
(pending)		 $64,018

Adeli, Khosrow (Hospital for Sick Children)

Molecular mechanisms of apolipoprotein B degradation

TYPE 4 Year
Renewal
 $111,063

Austin, Richard C. (McMaster University)

Role of endoplasmic reticulum stress in the development and progression of atherothrombotic disease

TYPE 3 Year
New
(pending)		 $87,378

Backx, Peter H. (Heart & Stroke Richard Lewar Centre)

Role of inward rectifier k+ and HCN channels in
heart

TYPE 3 Year
Renewal
(pending)		 $123,607

Ball, Eric H. (University of Western Ontario)

Metavinculin interactions in hereditary cardiomyopathy

TYPE 2 Year
New
(pending)		 $61,853

Bates, Shannon M. (McMaster University)

Diagnosis of suspected pulmonary embolism with D-dimer

TYPE 2 Year
Renewal
 $114,987

Beanlands, Rob S. B. (University of Ottawa Heart Institute)

Effects of continuous positive airway pressure therapy on myocardial energetics and sympathetic nerve function in patients with heart failure and obstructive sleep apnea

TYPE 2 Year
New
(pending)		 $119,691

Benazon, Nili R. (Centre for Addiction and Mental Health)

Correlates of women's compliance with exercise prescriptions during and following cardiac rehabilitation

TYPE 2 Year
New
(pending)		 $52,696

Borger, Michael A. (Toronto General Hospital, UHN)

Minimal invasive cardiac surgery: Is it safe for the brain?

TYPE 2 Year
New
(pending)		 $118,499

Boughner, Derek R. (University of Western Ontario)

Aortic sclerosis in an animal model: progression, regression and evaluation

TYPE 2 Year
New
(pending)		 $77,150

Cepinskas, Gediminas (Lawson Health Research Institute)

The mechanisms of neutrophil-induced negative feedback regulation of transcription factor, NFKB in endothelial cells during inflammation: role of PECAM1(CD31)

TYPE 2 Year
New
(pending)		 $49,540

Chan, Anthony K.C. (McMaster University)

Study of the pathogenesis and treatment of pediatric disease related to the hemostatic system

TYPE 5 Year
Career Investigator
  

Chan, Anthony K.C. (McMaster University)

The influence of age on the protein C pathway during chemotherapy treatment

TYPE 2 Year
New
 $79,134

Chan, Christopher T.M. (Toronto General Hospital, UHN)

Impact of uremia on endothelial progenitor cells

TYPE 2 Year
New
 $66,937

Chidiac, Peter (University of Western Ontario)

RGS proteins in the heart

TYPE 2 Year
New
(pending)		 $85,085

Clarke, Bryan J. (McMaster University)

Factor VII as an inhibitor of coagulation

TYPE 1 Year
Renewal
 $33,900

Coles, John G. (Hospital for Sick Children)

Integrin-linked kinase (ILK) induces adaptive remodeling in dilated cardiac failure

TYPE 2 Year
New
(pending)		 $85,535

Connelly, Philip W. (St. Michael's Hospital)

Identification of the mechanisms of oxidation of high density lipoproteins in vivo in the mouse

TYPE 1 Year
Renewal
 $33,900

Connelly, Philip W. (St. Michael's Hospital)

Comparative studies of paraoxonase 1 and paraoxonase 3

TYPE 3 Year
Renewal
(pending)		 $58,653

Courtman, David W. (St. Michael's Hospital)

Arterial remodeling: regulation of aneurysm growth

TYPE 2 Year
New
(pending)		 $68,000

Crowther, Mark A. (McMaster University)

Tinzaparin for treatment of venous
thromboembolism in renal insufficiency: a pilot
study

TYPE 2 Year
New
(pending)		 $58,593

Davies, Peter L. (Queen's University)

Calcium-activated proteases in health and disease

TYPE 5 Year
Renewal
(pending)		 $119,931

de Bold, Adolfo J. (University of Ottawa Heart Institute)

Molecular physiology of the endocrine heart

TYPE 1 Year
Renewal
 $33,900

Demers, Catherine (McMaster University)

A prospective evaluation of a novel primary care heart failure management program

TYPE 1 Year
Renewal
 $85,657

Drangova, Maria (Robarts Research Institute)

Optimized micro-CT o the mouse heart and coronary vasculature

TYPE 2 Year
New
(pending)		 $66,135

Duncan, Alison M. (University of Guelph)

Effect of soy protein on glycemic control and serum lipids in people with type 2 diabetes

TYPE 2 Year
New
(pending)		 $43,400

Eikelboom, John W.A. (McMaster University)

Determining the mechanisms of aspirin resistance

TYPE 2 Year
New
(pending)		 $119,820

Ellis, Christopher (University of Western Ontario)

Local regulation of microvasculature oxygen exchange

TYPE 2 Year
Renewal
 $70,599

Feng, Qingping (University of Western Ontario)

Mechanisms of heart failure

TYPE 5 Year
Career Investigator
  

Finestone, Hillel M. (Elisabeth Bruyere Health Centre)

Driving post-stroke: A prospective study of community integration and driving habits

TYPE 2 Year
New
(pending)		 $67,088

Fremes, Stephen E. (Sunnybrook and Women's College Health Sciences Centre)

Graft imaging to improve patency (GRIIP) study

TYPE 2 Year
New
(pending)		 $99,851

Gagnon, France (University of Ottawa)

Genome-wide search for oligogenes in factor V Leiden thrombophilia

TYPE 3 Year
New
(pending)		 $55,537

Gaisano, Herbert Y. (University of Toronto)

SNARE regulation of cardiac sulfonylurea receptor,
a novel drug target for cardiac ischemia

TYPE 2 Year
New
(pending)		 $72,943

Garland, S. Jayne (University of Western Ontario)

Standing balance following stroke: a novel approach for postural muscle retraining

TYPE 3 Year
New
 $58,160

Giacca, Adria (University of Toronto)

Anti-atherogenic effect of insulin in vivo

TYPE 3 Year
Renewal
 $35,776

Glover, Christopher A. (University of Ottawa Heart Institute)

Stem cell mobilization in post myocardial infarction patients to promote cardiomyocyte repair

TYPE 2 Year
New
(pending)		 $66,969

Goldfield, Gary S. (Children's Hospital of Eastern Ontario)

Family-based behavioural treatment for childhood obesity delivered via internet: a randomized controlled trail

TYPE 2 Year
New
 $50,000

Graham, Charles H. (Queen's University)

Mechanisms regulating the development and pathophysiology of pre-eclamptic hypertension

TYPE 2 Year
Renewal
(pending)		 $89,941

Graham, Simon J. (Sunnybrook and Women's College Health Sciences Centre)

Virtual reality for stroke recovery: initial fMRI studies

TYPE 2 Year
New
(pending)		 $48,580

Grant, David R. (Toronto General Hospital, UHN)

Role of fg12 in transplantation and cardiac development

TYPE 3 Year
Renewal
 $75,947

Gwadry-Sridhar, Femida (London Health Sciences Centre)

Knowledge innovation and diffusion in myocardial infarction

TYPE 2 Year
New
(pending)		 $60,420

Hammond, James R. (University of Western Ontario)

Role of Nucleoside transporters in the regulation
of the vascular effects of adenosine and its
metabolites

TYPE 3 Year
Renewal
 $69,473

Hatton, Mark W. C. (McMaster University)

Comparative study of the procoagulant and pro-fibrinolytic nature of VX-2 tumours and their effusions when located in different body compartments of rabbits

TYPE 3 Year
Renewal
(pending)		 $68,873

Hayward, Catherine P. (McMaster University)

Studies of novel platelet and vascular secretory proteins

TYPE 5 Year
Career Investigator
  

Hegele, Robert A. (Robarts Research Institute)

Genetic determinants of coronary heart disease

TYPE 2.5 Year
Career Investigator
  

Huff, Murray W. (Robarts Research Institute)

Regulation of ApoB metabolism: relationship to atherosclerosis

TYPE 5 Year
Renewal
 $133,489

Hughson, Richard L. (University of Waterloo)

Integrative cerebrovascular and cardiovascular responses: effects of age and gender

TYPE 1 Year
Renewal
(pending)		 $33,900

Karmazyn, Morris (University of Western Ontario)

Modulation of cardiomyocyte hypertrophy by nitric oxide and endothelin-1 in the aging myocardium

TYPE 4 Year
Renewal
 $95,296

Kawaja, Michael David (Queen's University)

Sympathetic hyperinnervation associated with the hypertensive phenotype of rats and mice

TYPE 3 Year
Renewal
(pending)		 $74,772

Kearon, Clive (McMaster University)

Thrombosis in family members of patients with unprovoked venous thromboembolism

TYPE 2 Year
Renewal
(pending)		 $67,154

Kelton, John G. (McMaster University)

Platelet-medicated acute thrombotic disorders

TYPE 5 Year
Renewal
 $137,237

Koschinsky, Marlys L. (Queen's University)

Interaction of Lp(a) with the plasminogen system: mechanisms and pathophysiological
consequences

TYPE 5 Year
Renewal
 $90,732

Kutryk, Michael J. B. (St. Michael's Hospital)

Novel applications of progenitor endothelial cells

TYPE 2 Year
Renewal
(pending)		 $42,597

Lee, Robert M.K.W. (McMaster University)

Alterations in hypertensive arteries

TYPE 3 Year
Renewal
 $73,171

Letarte, Michelle V. (Hospital for Sick Children)

Role of endoglin in normal vasculature and in the pathology of HHT

TYPE 4 Year
Renewal
 $90,097

Lewis, Gary F. (Toronto General Hospital, UHN)

Regulation of HDL metabolism

TYPE 3 Year
Renewal
(pending)		 $87,460

Leytin, Valery (St. Michael's Hospital)

Platelet apoptosis induced by chemical agonists
and shear stresses

TYPE 3 Year
Renewal
(pending)		 $74,476

Lillicrap, David (Queen's University)

The role of von willebrand factor in arterial thrombosis

TYPE 2.5 Year
Career Investigator
  

Lillicrap, David (Queen's University)

The role of von Willebrand factor in arterial thrombosis

TYPE 3 Year
Renewal
 $89,185

Liu, Fang (Centre for Addiction and Mental Health)

Uncoupling the protein-protein interaction between
mGluR5 and NMDA receptors: a new approach in
the treatment of stroke

TYPE 2 Year
Renewal
(pending)		 $49,022

Liu, Peter P. (Toronto General Hospital, UHN)

"Danger signal", cell injury and "innate immune response" in regulating inflammation in cardiovascular disease

TYPE 5 Year
Renewal
(pending)		 $104,656

Logan, Alexander G. (Mount Sinai Hospital)

Physician and patient surveys of home/self blood pressure monitoring

TYPE 1 Year
New
(pending)		 $59,749

Lucas, Alexandra R. (Robarts Research Institute)

Mechanisms of serpin regulation of vascular repair

TYPE 1 Year
Renewal
 $33,900

Mak, Susanna (Mount Sinai Hospital)

Estrogen and cardiac function in humans with and without heart failure

TYPE 2 Year
New
(pending)		 $50,582

Marsden, Philip A. (University of Toronto)

Post-transcriptional regulation of eNOS expression

TYPE 4 Year
Renewal
 $95,069

Marshall, John G. (Ryerson University)

Biophysical and biochemical approaches to the diagnosis of myocardial infarction and stroke

TYPE 2 Year
New
(pending)		 $73,900

Megeney, Lynn A. (Ottawa Health Research Institute)

Non-linear modeling of MAPK induced cardiac hypertrophy

TYPE 2 Year
New
(pending)		 $67,745

Mehta, Sanjay (University of Western Ontario)

Microvascular entothelial cell injury in murine sepsis

TYPE 3 Year
New
(pending)		 $96,665

Melo, Luis Gabriel (Queen's University)

Cell based gene therapy to enhance healing and recovery of infarcted myocardium

TYPE 2 Year
New
(pending)		 $89,906

Milne, Ross W. (University of Ottawa Heart Institute)

Advanced glycation end products and diabetic atherosclerosis

TYPE 2 Year
New
 $66,245

Min, Wei-Ping (University of Western Ontario)

Cellular therapy for transplant rejection by T regulatory cells generated through interaction with genetically modified dendritic cells

TYPE 2 Year
New
(pending)		 $69,771

Monnier, Philippe P. (Toronto Western Hospital, UHN)

Mechanisms that control repulsive guidance molecule (RGM) biological activity

TYPE 2 Year
New
(pending)		 $68,970

Morley, Paul (National Research Council of Canada)

Synaptic and extrasynaptic NMDA receptors in preconditioning

TYPE 3 Year
Renewal
(pending)		 $64,729

Nesheim, Michael E. (Queen's University)

The activation of TAFI and the properties of TAFIa

TYPE 5 Year
Renewal
 $83,859

Newton, Gary E. (Mount Sinai Hospital)

Free radical modulation of sympathetic activity and mechanical efficiency in the normal and failing human heart

TYPE 3 Year
Renewal
(pending)		 $64,264

Ng, Dominic S.K. (St. Michael's Hospital)

LCAT deficiency in lipid dysregulation - a murine model

TYPE 2 Year
New
(pending)		 $69,400

Ni, Heyu (St. Michael's Hospital)

Novel mechanisms of platelet aggregation: role of alternative ligands of beta3 integrin in thrombosis and hemostasis

TYPE 3 Year
Renewal
(pending)		 $64,232

O'Brien, Edward R. (University of Ottawa Heart Institute)

NM23-H2, an estrogen receptor beta associated protein: alterations in signal regulation and role in vascular cell function

TYPE 3 Year
Renewal
 $68,540

O'Brodovich, Hugh (Hospital for Sick Children)

New approach to augment clearance of pulmonary edema

TYPE 3 Year
Renewal
 $98,296

Opavsky, Mary Anne (Hospital for Sick Children)

The coxsackie-adenovirus receptor: function meets infection in viral myocarditis and dilated cardiomyopathy

TYPE 2 Year
Renewal
 $85,156

Parkinson, John (Hospital for Sick Children)

A combined theoretical/experimental approach to understanding sequence - structure - function relationships in elastin and elastin-like peptides

TYPE 2 Year
New
(pending)		 $38,560

Pickering, J. Geoffrey (London Health Sciences Centre)

Regulation of smooth muscle cell differentiation and longevity

TYPE 5 Year
Renewal
 $101,106

Pyle, William G. (University of Guelph)

Hormonal regulation of myocardial function

TYPE 2 Year
New
 $52,201

Reid, Robert D. (University of Ottawa Heart Institute)

Efficacy and cost-effectiveness of behavioural
counseling for exercise behaviour in men and
women following AMI and PCI

TYPE 2 Year
New
 $76,997

Renaud, Leo P. (Ottawa Health Research Institute)

Suprachiasmatic nucleus efferents

TYPE 3 Year
Renewal
 $62,394

Robinson, Lisa A. (Hospital for Sick Children)

Cellular regulation of fractalkine

TYPE 2 Year
New
 $85,972

Rodger, Marc A. (Ottawa Health Research Institute)

TAPP - thrombophilia and placental pathology

TYPE 3 Year
New
(pending)		 $41,336

Rubens, Fraser D. (University of Ottawa Heart Institute)

Transfusion reduction and modified ultrafiltration after cardiopulmonary bypass (TRAM trial) - a pilot feasibility trial

TYPE 1 Year
New
(pending)		 $122,941

Rubin, Barry B. (Toronto General Hospital, UHN)

Impact of mPGES-1 gene deletion on myocardial ischemia reperfusion injury

TYPE 2 Year
New
 $77,308

Rush, James W.E. (University of Waterloo)

Exercise and antioxidants in hypertension:
vascular endothelial adaptations

TYPE 2 Year
Renewal
 $62,496

Schlichter, Lyanne C. (Toronto Western Hospital, UHN)

Targeting K channels to control inflammation in stroke

TYPE 3 Year
Renewal
(pending)		 $107,499

Sharma, Arya M. (McMaster University)

Biological determinants of the differences in metabolic and cardiovascular risk factors between South Asians and European Caucasians

TYPE 3 Year
New
(pending)		 $97,517

Sheffield, William P. (McMaster University)

Building novel antithrombotic serpins using
directed or selectable mutational approaches

TYPE 3 Year
Renewal
 $66,633

Sheffield, William P. (McMaster University)

Improving antithrombotic proteins and peptides by genetic fusion, combined administration, and engineered latency

TYPE 1 Year
Renewal
 $33,900

Siu, Samuel C. (Toronto General Hospital, UHN)

Maternal cardiac output and fetal well being in women with heart disease

TYPE 2 Year
New
 $45,400

Sorisky, Alexander (Ottawa Health Research Institute)

Regulation of adipogenesis

TYPE 3 Year
New
(pending)		 $70,000

Sparks, Daniel L. (University of Ottawa Heart Institute)

The role of HDL in triglyceride metabolism

TYPE 3 Year
Renewal
(pending)		 $62,253

Spence, J. David (Robarts Research Institute)

Biomarkers in vulnerable carotid plaque with microemboli or ulcers

TYPE 3 Year
Renewal
(pending)		 $94,700

Stewart, Duncan J. (St. Michael's Hospital)

Pathophysiological relevance of endothelin-1 over-expression

TYPE 3 Year
New
(pending)		 $103,800

Stewart, Duncan J. (St. Michael's Hospital)

NO synthase in cardiovascular health and disease

TYPE 3 Year
Renewal
(pending)		 $90,035

Stys, Peter K. (Ottawa Health Research Institute)

Ionotropic glutamate receptors in central myelinated axons

TYPE 3 Year
New
(pending)		 $128,207

Sweeney, Gary (York University)

Regulation of glucose and fatty acid uptake and metabolism in cardiomyocytes by adiponectin

TYPE 2 Year
New
(pending)		 $63,000

Templeton, Douglas M. (University of Toronto)

Mechanisms of iron accumulation and toxicity in cardiac myocytes and interstitial fibroblasts

TYPE 2 Year
Renewal
(pending)		 $71,969

Touyz, Rhian M. (University of Ottawa)

Vascular regulation by magnesium in hypertension

TYPE 3 Year
Renewal
(pending)		 $93,828

Trigatti, Bernardo L. (McMaster University)

Use of bone marrow transplantation to study the atheroprotective role of the scavenger receptor class B type I in the vascular wall

TYPE 2 Year
New
(pending)		 $81,085

Tsushima, Robert G. (University of Toronto)

Regulation of cardiac nonselective cation channels

TYPE 2 Year
Renewal
 $74,795

Tu, Jack V. (Institute for Clinical Evaluative Sciences)

Improving the quality of heart and stroke care in Canada

TYPE 5 Year
Career Investigator
  

Tu, Jack V. (Institute for Clinical Evaluative Sciences)

Improving the quality of acute myocardial infarction care in Canada

TYPE 3 Year
New
 $123,533

Tyml, Karel (University of Western Ontario)

Hypoxia/reoxygenation and vascular cell coupling

TYPE 3 Year
New
(pending)		 $90,800

Van Huysse, James W. (University of Ottawa Heart Institute)

Roles of the brain Na, K-ATPase isoforms in blood pressure regulation

TYPE 3 Year
Renewal
(pending)		 $92,037

Weisel, Richard D. (Toronto General Hospital, UHN)

Enhancing endogenous repair by cell therapy

TYPE 2 Year
New
(pending)		 $68,192

Wells, James W. (University of Toronto)

Nature of the signalling complex between cardiac muscarinic receptors and G proteins

TYPE 3 Year
Renewal
(pending)		 $86,292

Wells, Philip S. (Ottawa Health Research Institute)

The role of inflammation and thrombophilia in the post-thrombotic syndrome: the bio-sox study

TYPE 2 Year
New
(pending)		 $50,445

Wen, Shi Wu (Ottawa Health Research Institute)

Environmental carbon monoxide (CO) level and
the risk of pre-eclampsia (PE) - summary of
research proposal

TYPE 2 Year
New
(pending)		 $21,235

Werstuck, Geoffrey H. (McMaster University)

Investigating the role of GSK3 in atherogenesis: rational design, synthesis and screening of novel GSKL-3 inhibitors as anti-atherogenic therapies

TYPE 2 Year
New
(pending)		 $71,302

Whitman, Stewart C. (University of Ottawa Heart Institute)

The role of the innate immune system in atherosclerosis: defining the contribution of both natural killer cells and natural killer T cells to the disease process

TYPE 3 Year
Renewal
(pending)		 $96,461

Wisenberg, Gerald (London Health Sciences Centre)

Optimizing the administration of marrow-derived
stem cells to repair left ventricular structure and
function in a canine model of myocardial infarction

TYPE 2 Year
New
(pending)		 $99,030

Yang, Burton B. (Sunnybrook and Women's College Health Sciences Centre)

The role of the large aggregating chondroitin sulfate proteoglycan versican in angiogenesis

TYPE 2 Year
New
(pending)		 $63,752

Yao, Zemin (University of Ottawa Heart Institute)

Hepatic lipase and hypoalphalipoproteinemia

TYPE 2 Year
Renewal
 $64,465

Yusuf, Salim (McMaster University)

The INTERHEART study

TYPE 3 Year
New
 $147,450

Zha, Xiaohui (Ottawa Health Research Institute)

ABCA1-mediated cholesterol efflux and
intracellular cholesterol transport

TYPE 3 Year
Renewal
(pending)		 $69,317

Zhang, Liang (Toronto Western Hospital, UHN)

Hippocampal hyperexcitability in rats after prolonged post-ischemic survival: a model of post-stroke epileptic seizures

TYPE 2 Year
New
(pending)		 $66,008
Last Updated ( Wednesday, 06 June 2007 )