2000/2001 Research Fellows

• * Anderson, Christopher M. (Neurology, University of California, San Francisco)
  Mechanisms and regulation of CNS glutamate transport and neurotoxicity.
  Supervisor: Swanson, Raymond A.
  


• * Benisty, Jacques (Surgery & Cell Biology, Children's Hospital)
  Angiogenic growth factors in pulmonary vascular disease.
  Supervisor: Folkman, Judah
  


• * Booth, James W. (Programme in Cell Biology, Hospital for Sick Children)
  Role of Tic and Arf6 in leukocyte activation: role in ischemia-reperfusion.
  Supervisor: Grinstein, Sergio
  


• * Carpentier, André (Medicine, The Toronto Hospital-General Division)
  Investigation of the mechanisms of VLDL-apolipoprotein B100 overproduction in insulin resistant states.
  Supervisor: Lewis, Gary F.
  


• Chopra, Gopal K. (Neuroprotection Laboratory, Toronto Western Hospital)
  Non-excitotoxic mechanisms of anoxic neuronal damage.
  Supervisor: Tymianski, Michael
  


• Cregan, Sean P. (Neuroscience Research Institute, University of Ottawa)
  The role of APAF1 in p53-induced neuronal cell death.
  Supervisor: Slack, Ruth
  


• Cunningham, Michael A. (Biological Chemistry, University of Michigan)
  Elucidation of the phospholipid binding site on human factor VIII.
  Supervisor: Kaufman, Randal J.
  


• * Czubryt, Michael P. (Molecular Biology, University of Texas Southwestern Medical Centre at Dallas)
  Role of MEF2 in cardiac hypertrophy.
  Supervisor: Olson, Eric N.
  


• * Datta, Partha (Cardiology, St. Michael's Hospital)
  The role of endothelins in a mouse model of aortic aneurysm formation.
  Supervisor: Stewart, Duncan J.
  


• * Demaerschalk, Bart Maurice (Clinical Neurology Sciences, University of Western Ontario)
  The impact of an evidence-based stroke educational intervention on clinical outcomes.
  Supervisor: Hachinski, Vladimir C.
  


• Derakhchan Khadjou , Katayoun (Medicine, Montreal Heart Institute)
  Three-dimensional mapping of atrial fibrillation.
  Supervisor: Nattel, Stanley
  


• Deschenes, Isabelle (Medicine, John Hopkins University)
  Motions in the external pore of the sodium channel probed by paired cysteine mutagenesis and fluorescent labeling.
  Supervisor: Tomaselli, Gordon F.
  


• * Devereaux, Philip J. (Clinical Epidemiology & Biostatistics, McMaster University)
  Evaluation of perioperative cardiac risk and modification.
  Supervisor: Guyatt, Gordon H.
  


• * Ding, Hao (Molecular & Cellular Biology, Samuel Lunefeld Research Institute)
  Neoangiogenesis in cerebral ischemia.
  Supervisor: Guha, Abhijit
  


• * Dumont, Aaron S. (Neurosurgery, Foothills Hospital)
  Metabolism and the ischemic brain: new perspectives.
  Supervisor: Sutherland, Garnette R.
  


• Duriez, Patrick J. (Pathology & Laboratory Medicine, St. Paul's Hospital)
  Role of Notch4 during endothelial apoptosis.
  Supervisor: Karsan, Aly
  


• Eikelboom, John W. (Preventive Cardiology & Therapeutics, Hamilton General Hospital)
  Direct thrombin inhibitor trialists' collaborative project.
  Supervisor: Yusuf, Salim
  


• * Fedak, Paul W. (Cardiac Surgery, University of Toronto)
  Experimental cardiomyocyte transplantation to improve left ventricular function in chronic decompensated mitral regurgitation.
  Supervisor: Weisel, Richard D.
  


• * Gladstone, David J. (Medicine, Sunnybrook & Women’s College Health Sciences Centre)
  Amphetamine for stroke recovery: a clinical and fMRI study.
  Supervisor: Black, Sandra E.
  


• Golfman, Leonard S. (Biochemistry, University of Alberta)
  Transcriptional regulation of cytidylyltransferase during the cell cycle.
  Supervisor: Vance, Dennis E.
  


• Grand'Maison, Anne (Medicine, McMaster University)
  Pharmacokinetic profile of subcutaneous low-molecular-weight-heparin in overweight and underweight patients with acute venous thromboembolism.
  Supervisor: Ginsberg, Jeffrey S.
  


• Guo, Lei (Biochemistry, University of Alberta)
  Transcriptional control of cardiac expression of calreticulin.
  Supervisor: Michalak, Marek
  


• Han, Hong (Medicine, Montreal Heart Institute)
  Role of potassium channels in cardiomyocyte apoptosis.
  Supervisor: Wang, Zhiguo
  


• Hennan, James K. (Pharmacology, University of Michigan)
  Role of the complement system in mediating myocardial injury and pharmacological cardioprotection.
  Supervisor: Lucchesi, Benedict R.
  


• Hilairet, Sandrine (Biochimie, Université de Montréal)
  Mecanismes de regulation du recepteur du CGRP et de l'adrenomedulline (CRLR) par les proteines RAMPs.
  Supervisor: Bouvier, Michel
  


• * Hill, Michael D. (Neuroscience, University of Calgary)
  Validation of the Alberta Stroke Program Early CT Score (ASPECTS) in patients treated with rtPA for acute stroke: Early prediction of outcome
  Supervisor: Buchan, Alastair M.
  


• * Hirasawa, Michiru (Physiology and Biophysics, University of Calgary)
  Mechanism of neurotransmitter release and plasticity in the supraoptic nucleus.
  Supervisor: Pittman, Quentin J.
  


• * Huang, Yue-Qiao (Brain and Behavior, Hospital for Sick Children)
  NMDA receptor regulation by Src: A role of PSD-95.
  Supervisor: Salter, Michael W.
  


• * Jahromi, Babak S. (Neurosurgery, University of Chicago)
  Effect of subarachnoid hemorrhage and vasospasm on smooth muscle calcium homeostasis.
  Supervisor: Macdonald, Robert L.
  


• * Jong, Phillip (Cardiology, University of Toronto)
  Effect of enalapril on long-term mortality and morbidity in patients with left ventricular systolic dysfunction.
  Supervisor: Liu, Peter P.
  


• Jutras, Isabelle (Physiopathology, Pasteur Institute)
  Interactions of the intrcellular pathogen chlamydia with host cells: effects on cellular trafficking.
  Supervisor: Dautry-Varsat, Alice
  


• * Kahr, Walter (Pathology & Molecular Medicine, McMaster University)
  Characterization of the platelet enzyme defect in the Quebec platelet disorder.
  Supervisor: Hayward, Catherine P.
  


• Kaprielian, Roger (Cardiovascular Research Centre, Massachusetts General Hospital)
  Role of Kv4.3 and SERCA2a on [Ca2+]i and signal transduction in cardiac failure.
  Supervisor: Hajjar, Roger
  


• * Kaul, Padmaja (Medicine, Duke University Medical Centre)
  Long-term impact of early revascularization in AMI patients: Canada versus the US.
  Supervisor: Mark, Daniel B.
  


• Krebs, Claudia (Physiology, University of British Columbia)
  Calbindin and NMDA receptor subtypes in ischemia/anoxia-induced neuron death.
  Supervisor: Baimbridge, Kenneth G.
  


• Lagaud, Guy (Pharmacology & Therapeutics, University of British Columbia)
  Calcium gradients regulate endothelial secretions.
  Supervisor: Van Breemen, Casey
  


• * Lam, Buu-Khanh (Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation)
  Defining the appropriate roles for valve replacement versus valve repair in the spectrum of mitral valve disease.
  Supervisor: Blackstone, Eugene H.
  


• * Lee, Douglas S.Y. (Medicine & Public Health Sciences, University of Toronto)
  Determination of prognosis and outcomes of congestive heart failure in Ontario.
  Supervisor: Tu, Jack V.
  


• * Leong-Poi, Howard M. (Cardiovascular, University of Virginia)
  The non-invasive assessment of imflammation using contrast enhanced ultrasound.
  Supervisor: Kaul, Sanjiv
  


• Leung, Yuk Man (Physiology and Medicine, University of Toronto)
  The mechanisms of cardiac hypertrophy and disease following reductions in transient outward currents.
  Supervisor: Backx, Peter H.
  


• Li, Ronald A. (Medicine, John Hopkins University)
  Reversal of electrical defects in heart failure using adenoviral gene transfer.
  Supervisor: Marban, Eduardo
  


• Li, Timao (Physiology, University of Manitoba)
  Molecular mechanism of cytokine-induced apoptosis in adult ventricular myocytes.
  Supervisor: Kirshenbaum, Lorrie A.
  


• Liu, Qingde (Centre of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Centre)
  Protein histidine phosphorylation in platelet activation.
  Supervisor: Furie, Barbara
  


• Lomax, Alan (Physiology & Biophysics, University of Calgary)
  Na+/Ca2 and Na+/Ca2/K+ antiporters in the cardiovascular system.
  Supervisor: Giles, Wayne R.
  


• * Mallidi, Hari (Surgery, University of Toronto)
  Bioengineered tissue grafts to improve ventricular function in a porcine infarct model of heart failure.
  Supervisor: Weisel, Richard D.
  


• Massaeli, Hamid (Cardiovascular Research, University of Toronto)
  The role of apolipoprotein D in vascular smooth muscle cell motility.
  Supervisor: Rabinovitch, Marlene
  


• Masumiya, Haruko (Physiology & Biophysics, University of Calgary)
  Molecular characterization of the ion-conducting pore of the cardiac Ca2+ - release channel (ryanodine receptor).
  Supervisor: Chen, S.R. Wayne
  


• * Miner, Steven E. S. (Medicine, University of Toronto)
  Transcardiac L-arginine kinetics and nitric oxide synthase activity.
  Supervisor: Parker, John D.
  


• Nagai, Yoshihiko (Physiology, McGill University)
  Nonlinear dynamics of reentrant arrhythmias: experiment and theory.
  Supervisor: Glass, Leon
  


• Ni, Heyu (Pathology, Harvard University)
  Adhesion molecules in platelet adhesion and thrombus formation.
  Supervisor: Wagner, Denisa
  


• * Nong, Zengxuan (Medicine, University of Ottawa Heart Institute)
  Local delivery of estrogen receptor beta post-balloon injury.
  Supervisor: O'Brien, Edward R.
  


• Nygren, Anders (Physiology & Biophysics, University of Calgary)
  Voltage-sensitive dye recordings of cardiac rhythm disturbances: Image processing algorithms.
  Supervisor: Giles, Wayne R.
  


• * Oudit, Gavin Y. (Medicine, University of Toronto)
  Role of estradiol and L-type calcium channel in the pathophysiology of iron-overload.
  Supervisor: Backx, Peter H.
  


• Pan, Yan (Banting & Best Department of Medical Research, University of Toronto)
  Compensatory changes in muscle diseases arising from defects in calcium regulatory proteins.
  Supervisor: MacLennan, David H.
  


• Pheng, Leng Hong (Neurologie, Université McGill)
  Internalisation et trafic intracellulaire des recpteurs du NPY.
  Supervisor: Beaudet, Alain
  


• Pineyro, Graciela (Biochemistry, University of Montreal)
  Role of Gi-mediated responses in the pathophysiology of heart failure.
  Supervisor: Bouvier, Michel
  


• Raffai, Robert (Gladstone Institute of Cardiovascular Disease , The J. David Gladstone Institutes)
  An animal model for human apolipoprotein E4 and diet-induced hypercholesterolemia.
  Supervisor: Weisgraber, Karl H.
  


• * Raj, Satish (Medicine, University of Calgary)
  Influence of cardiac hypertrophy and gender on Class III antiarrhythmic drug effects.
  Supervisor: Gillis, Anne M.
  


• Rupert, Jim (Pathology, University of British Columbia)
  Genetic risk factors for cardiovascular disease in Native Americans.
  Supervisor: Devine, Dana V.
  


• Sambandam, Nandakumar (Pediatrics and Pharmacology, University of Alberta)
  5'AMP-activated protein kinase control of glucose metabolism in the newborn heart.
  Supervisor: Lopaschuk, Gary D.
  


• Schulze, Costas (Pediatrics & Pharmacology, University of Alberta)
  Role of matrix metalloproteinases in cytokine-mediated heart injury.
  Supervisor: Schulz, Richard
  


• Smieja, Marek J. (Medicine, McMaster University)
  A case-control study of the association of chlamydia pneumoniae and coronary atherosclerosis.
  Supervisor: Yusuf, Salim
  


• * Stewart, Ronald J. (Biochemistry, Queen's University)
  Characterizing the antifibrinolytic properties of TAFa.
  Supervisor: Nesheim, Michael E.
  


• * Storey, Margo K. (Medicine, National Jewish Medical and Research Center)
  The biochemistry and genetics of eucaryotic lipid transport and organelle biogenesis.
  Supervisor: Voelker, Dennis R.
  


• Taylor, R. Blaine (London Health Sciences Centre)
  MRI predictors of clinical outcomes in t-PA treated patients.
  Supervisor: Hachinski, Vladimir C.
  


• * Tsuda, Takeo (Banting & Best Department of Medical Research, University of Toronto)
  Conformational changes that accompany Ca2+ transport by SERCA molecules.
  Supervisor: MacLennan, David H.
  


• Tupling, Allan R. (Banting & Best Department of Medical Research, University of Toronto)
  Analysis of compensatory mechanisms in animal models of Ca2+ regulatory muscle diseases.
  Supervisor: MacLennan, David H.
  


• Turcato, Sally (Pharmacology & Therapeutics, University of Calgary)
  Regulation of vascular smooth muscle KNDP channels by PKC.
  Supervisor: Cole, William C.
  


• * Verma, Subodh (Cadiology, University of Calgary)
  Diabetes, atherosclerosis and endothelial dysfunction.
  Supervisor: Anderson, Todd J.
  


• Voisin, Laure (Centre de Recherche, Centre hospitalier de l’Université de Montéal)
  Bases moléculaires de l'action hypertrophique de l'angiotensine II dans les cellules musculaires lisses vasculaires.
  Supervisor: Meloche, Sylvain
  


• Wang, Xi (Pathology, University of Washington)
  Functional genomic of arterial unique genes.
  Supervisor: Schwartz, Stephen M.
  


• Wilcox, Lisa J. (Nutrition, Columbia University)
  Sterol trafficking and esterification.
  Supervisor: Sturley, Stephen
  


• Wilson, David P. (Biochemistry and Molecular Biology, University of Calgary)
  CA2+ sensitization of smooth muscle contraction.
  Supervisor: Walsh, Michael P.
  


• * Wu, Lingyun (Anatomy and Cell Biology, University of Saskatchewan)
  Management of oxidative stress and inflammation in brain microvasculature.
  Supervisor: Juurlink, Bernard H.J.
  


• Wu, Sheng-Qian (Pharmacology, University of Saskatchewan)
  Role of endothelin in diabetic vascular complications.
  Supervisor: Gopalakrishnan, Venkat
  


• * Young, Lynne E. (Nursing, University of Washington)
  Living at risk: Exploring risk for heart disease with low-income single mothers of dependent children.
  Supervisor: Cunningham, Susanna
  


• Yue, Lixia Y.L. (Pharmacological & Physiological Sciences, University of Chicago)
  Structural determinants of binding of local anesthetic QX derivatives to sodium channel.
  Supervisor: Clapham, David
  


• Zhang, Shetuan (Physiology, University of British Columbia)
  Modulation of cadiac potassium channels by cocaine.
  Supervisor: Fedida, David
  


• Zhang, Yi-Hong (Physiology & Biophysics, University of Calgary)
  Previous fever and anoxic response.
  Supervisor: Pittman, Quentin J.