2013/2014 Grant-in-Aid Grantees

Andrade, Jason (University of British Columbia)
Co-PI: Tang, Anthony
Double Short vs Standard Exposure Duration During Cryoballoon Pulmonary Vein Isolation: The DOSE Study

Austin, Richard (St. Joseph's Hospital)
Contribution of cell surface GRP78 to the development and progression of atherothrombosis

Bai, Donglin (University of Western Ontario)
Connexin43 and connexin40 mutants and cardiac arrhythmias

Beanlands, Rob (University of Ottawa Heart Institute)
Atherosclerotic plaque imaging using NaF and FDG imaging: Validation and Evaluation of Disease Progression. A Canadian Atherosclerosis Imaging Network (CAIN)-II Histopathology Validation study

Beaulieu, Christian (University of Alberta)
Advances in High Field MRI of Stroke

Blostein, Mark (Lady Davis Institute for Medical Research)
Role of gas6 and inflammation in the pathophysiology of venous thromboembolism.

Bolz, Steffen-Sebastian (University of Toronto)
Correcting CFTR dysfunction: a new therapeutic strategy for normalizing microvascular reactivity in heart failure

Brown, Craig (University of Victoria)
Co-PI: Nashmi, Raad
A role for alpha-4 nicotinic acetylcholine receptors in regulating stroke recovery

Cerruti, Marta (McGill University)
Co-PI: Murshed, Monzur
A multidisciplinary approach to unravel the mystery of vascular calcification

Chakrabarti, Subrata (University of Western Ontario)
Vasoactive and cardioactive factors in diabetic heart disease

Chen, Hsiao-Huei (Ottawa Hospital Research Institute)
Modulation of innate immunity to reduce stroke injury and improve recovery.

Clanachan, Alexander (University of Alberta)
Co-PI: Zaugg, Michael
Novel therapy against ischemia-reperfusion injury in the infarct-remodeled heart

Claydon, Victoria (Simon Fraser University)
Cardiovascular autonomic control in acute spinal cord injury

Copeland, John (University of Ottawa)
Shear stress induced activation of cytoskeletal signaling pathways

Crowther, Mark (McMaster University)
Rivaroxaban for the secondary prevention of thromboembolism in patients with the antiphospholipid antibody syndrome

Cullen, Nora (University Health Network)
Life After Death: A Pilot Study Investigating Whole-Person Recovery After Out-of-Hospital Cardiac Arrest

Cummins, Carolyn (University of Toronto)
EPCs in atherosclerosis: Role of intracellular cholesterol and LXR signaling

Dakshinamurti, Shyamala (University of Manitoba)
Effect of Neonatal Hypoxia on Pulmonary Artery and Right Ventricle Adenylyl Cyclase

D'Avanzo, Nazzareno(Université de Montréal)
Lipid Regulation of Purified Eukaryotic Potassium Channels

Devereaux, Philip (McMaster University)
Co-PI: Srinathan, Sadeesh
Postoperative NT-proBNP Study

Dixon, Ian (University of Manitoba)
Ski and Scleraxis form a negative feedback loop in regulation of cardiac myofibroblast function

Dukelow, Sean (University of Calgary)
A Randomized Controlled Trial of Early Robotic Rehabilitation of the Upper Limb following Stroke

Gamble, John-Michael (Memorial University of Newfoundland)
Co-PI: Majumdar, Sumit
Comparative Cardiovascular Effectiveness of the Incretins

Giacca, Adria (University of Toronto)
Resveratrol and nitric oxide delivery as strategies to bypass vascular insulin resistance

Goldfield, Gary (Children's Hospital of Eastern Ontario)
Effects of Prenatal Exposure to Cigarettes on Adiposity and Metabolism in Young Children

Graham, Simon (Sunnybrook Health Sciences Centre)
FMRI neurofeedback applied to motor imagery in stroke

Grant, David (Toronto General Hospital)
Co-PI: Levy, Gary
fgl2/FGL2 and Heart Allotransplantation

Gros, Robert (University of Western Ontario)
The Protective Role of the Cholinergic System in the Heart

Hess, David (Robarts Research Institute)
Progenitor cell regulation of the vascular regenerative niche

Ikura, Mitsuhiko (University Health Network)
Structural basis for STIM and Orai function in the heart and vasculature

Jacques, Danielle (Université de Sherbrooke)
Regulation of secretion of cardiac endocardial endothelial cells by neuropeptide Y

Jerath, Angela (Toronto General Hospital)
Plasma concentration and pharmacokinetics of tranexamic acid in patients with renal impairment undergoing cardiopulmonary bypass surgery

 Keeley, Fred (Hospital for Sick Children)
Effects of sequence polymorphisms in human tropoelastin on the assembly and mechanical properties of the elastic matrix. Implications for susceptibility to later onset vascular disease.

Koschinsky, Marlys (University of Windsor)
Role of Oxidized Phospholipids in the Pathogenicity of Lipoprotein(a)

Krahn, Andrew (University of British Columbia)
CASPER: Canadian Genetic Heart Rhythm Network

Kriz, Jasna (Centre Hospitalier Universitaire de Québec)
Co-PI: Sato, Sachiko
The role of galectin-3 in post-ischemic immune responses

Kryworuchko, Jennifer (University of Saskatchewan)
Evaluation of a novel cardiopulmonary resuscitation (CPR) video decision aid to promote shared decision-making with seriously ill patients and their families

Kuebler, Wolfgang (St. Michael's Hospital)
The mast cell - B cell axis in lung vascular remodelling and pulmonary hypertension

Lee, Douglas (Toronto General Hospital Research Institute)
Early Phase Interventions for Acute Ischemic Heart Failure

Longmuir, Patricia (Children's Hospital of Eastern Ontario)
LIFE and Health for Young Children with Congenital Heart Defects
(Learning, Inclusion, Friends and Emotional and physical Health)

Macdonald, Robert (St. Michael's Hospital)
Co-PI: Bolz , Steffen-Sebastian
TNFα Signaling in Subarachnoid Hemorrhage

Madden, Kenneth (University of British Columbia)
Acarbose and Older Adults with Postprandial Hypotension

McGavock, Jonathan (University of Manitoba)
Co-PI: Dolinksy, Vernon
Developmental origins of diabetic cardiomyopathy

McKay, Heather (University of British Columbia)
ACTIVE STREETS, ACTIVE PEOPLE - JUNIOR: An Integrated Community Partnership to Enhance Physical Activity and Active Transport to School in Children and Youth

McNally, James (Children's Hospital of Eastern Ontario)
Prevention of post-operative vitamin D deficiency in children with congenital heart disease: a dose evaluation trial

Mehta, Sanjay (London Health Sciences Centre)
Mechanisms of Microvascular Endothelial Cell Apoptosis in Sepsis

Meyre, David (McMaster University)
Contribution of the lipid sensor GPR120 loss-of-function coding variant R270H to energy intake, obesity and type 2 diabetes in humans

Michelakis, Evangelos (University of Alberta)
A chamber-specific mitochondria-angiogenesis axis underlies right ventricular failure in pulmonary hypertension

Mielniczuk, Lisa (University of Ottawa Heart Institute)
Right Ventricular Substrate Metabolism as a Predictor of Right Heart Failure in Patients with Pulmonary Arterial Hypertension (RV-MET Study)

Min, Wei-Ping (University of Western Ontario)
The role of mTOR and TLR signaling networks on alloimmune modulation in heart transplantation

Monnier, Philippe (Toronto Western Hospital)
Modulation of the RGMa/Neogenin pathway promotes cell survival and regeneration after stroke

Mourad, Walid (Centre hospitalier de l'université de Montréal)
Role of CD154 and its Receptors in Atherothrombosis

Murphy, Timothy (University of British Columbia)
Using light to probe and modify neuronal excitability and blood flow of the evolving ischemic penumbra.

Nattel, Stanley (Montreal Heart Institute)
Factors altering the interaction between antiarrhythmic drugs and cardiac tissue: Role of nuclear receptors and remodeling

O'Brien, Edward (University of Calgary)
Heat Shock Protein 27: Extracellular Release and Signaling

Ohinmaa, Arto (University of Alberta)
Co-PI: Klarenbach, Scott
Canadian health outcomes, performance and efficiency (CanHOPE) - project for analysis of AMI and stroke care data for policy making

Park, David (University of Ottawa)
The Role of Pink1 in Stroke

Parkash, Ratika (Capital Health (NS))
CHRS Cardiac Implantable Electrical Device Surveillance System (CDSS) – A Pilot Study

Parkinson, John (Hospital for Sick Children)
Towards a systems level understanding of the elastic fibre and its role in cardiovascular disease

Pausova, Zdenka (Hospital for Sick Children)
Visceral fat and hypertension: sex-specific lipidomic biomarkers across generations

Pavlov, Evgeny (Dalhousie University)
Molecular basis of the pathological mitochondrial membrane transport: roles of inorganic polyphosphate and polyhydroxybutyrate

Plane, Frances (University of Alberta)
Endothelial Potassium Channels as Targets for Novel Vascular Drugs

Poulin, Marc (University of Calgary)
Role of Intermittent Hypoxia in the Pathogenesis of Obstructive Sleep apnea

Pryzdial, Edward (Canadian Blood Services)
Auxiliary Cofactors in Fibrinolysis

Reid, Robert (University of Ottawa Heart Institute)
Randomized Trial of Nordic Walking vs. Standard Cardiac Rehabilitation in Patients with Heart Failure

Rousseau, Guy(Hôpital du Sacré-Coeur de Montréal)
The importance of resolvins in the cardioprotective effect of omega-3 fatty acids

Scholey, James (University of Toronto)
Adiponectin Signaling Pathways and Diabetic Kidney Injury

Schweizer, Tom (St. Michael's Hospital)
Understanding Post-Stroke Driving Capacity: an fMRI Driving Simulator Study

Seubert, John (University of Alberta)
Role of Eicosanoids in Regulating Mitochondrial Quality In the Aged Heart

Shargall, Yaron (McMaster University)
Extended out-of-hospital VTE prophylaxis against Deep Venous Thrombosis and Pulmonary Embolus in patients undergoing major lung resection: A pilot study to evaluate the incidence of DVT and PE

Smith, Eric (University of Calgary)
Relationship Between Covert Brain Ischemia and Cognitive and Physical Decline in Middle-Aged Canadians

Stanford, William (Ottawa Hospital Research Institute)
The role of aberrant Lamin A splice isoforms in vascular smooth muscle aging and disease.

Steinman, David (University of Toronto)
Hemodynamics of Cerebral Aneurysms: Back to Basics

Stickland, Michael (University of Alberta)
Mechanisms and functional significance of enhanced carotid chemosensitivity in health and heart failure.

Stiell, Ian (Ottawa Hospital Research Institute)
A Randomized, Controlled Comparison of Electrical versus Pharmacological Cardioversion for Emergency Department Patients with Recent-Onset Atrial Fibrillation and Flutter (RAFF)

Sun, Hong-Shuo (University of Toronto)
Cellular and Molecular Mechanisms of Stroke in Diabetes and Its Potential Therapeutic Treatments.

Sweeney, Gary (York University)
Metabolic effects of adiponectin on the heart: mechanisms and functional consequences.

Sweeney, Gary (York University)
Regulation of cardiac structure and function by lipocalin-2

Trigatti, Bernardo (McMaster University)
Molecular mechanisms by which interleukin-15 contributes to the development of atherosclerosis

Tu, Karen (Institute for Clinical Evaluative Sciences (ICES))
Improving Stroke Prevention For Patients with Atrial Fibrillation in Primary Care

Veenstra, Gerry (University of British Columbia)
Using combined waves of the Canadian Community Health Survey to investigate distinct and intersecting effects of race, gender, class and sexual orientation on cardiovascular health outcomes

Verma, Subodh (St. Michael's Hospital)
Co-PI: Anderson, Todd
The Role of Autophagy in Cardiovascular Disease: A Bench to Bedside Translational Approach

Verma, Subodh (St. Michael's Hospital)
Elucidating the Role of BRCA1 as a target to improve endothelial function, promote angiogenesis and attenuate atherosclerosis

Weitz, Jeffrey (McMaster University)
Impact of Gamma'-fibrinogen on clot formation and clot lysis at sites of plaque rupture

Wijeysundera, Duminda (St. Michael's Hospital)
Co-PI: Cuthbertson, Brian
The METS Study: An International Multicentre Prospective Cohort Study of Cardiopulmonary Exercise Testing For Improving Preoperative Risk Stratification for Major Non-Cardiac Surgery

Wu, Lily (Lakehead University)
Regulation of aldolase B expression and scavenging methylglyoxal in vascular
smooth muscle cells

Zehr, E. Paul (University of Victoria)
Tapping into interlimb neuronal linkages to enhance locomotor ability after stroke


Grants-in-Aid Competition Results - Archive