Grant-in-Aid and Career Investigator Competitions - Results of September 2006

The Heart and Stroke Foundation of Ontario is pleased to announce the scientists from Ontario who were awarded Grant-in-Aid / Career Investigator funding in the September 2006 competition.

The results posted below are to be considered preliminary only. An official letter will be sent to all applicants the week of March 19, 2007, along with the budget / funding details and rankings. Career Investigator awards do not have first year amounts, however the standard stipend applies.
For those awards identified as "pending", funding is encumbered until additional information is provided. Applicants will be contacted in the near future in this regard. Some proposals were not ranked highly enough to receive full funding. In such cases, the Foundation has provided a terminal award, in order to assist scientists in maintaining some level of research activity until a re-application can be made.
The Foundation requests that applicants do not write or telephone with any enquiries before receiving the award letters.
  • Adeli, Khosrow (Hospital for Sick Children)
    Molecular mechanisms of hepatic VLDL overproduction in insulin resistance
    5 Year, Renewal, $115,917
  • Alhesayen, Abdurrahman, O (St. Michael's Hospital)
    Exploring the role of cGMP in human heart failure
    3 Year, New Annual (Pending), $75,452
  • Athale, Uma H. (McMaster University)
    Evaluation for inherited and acquired prothrombotic defects predisposing to symptomatic thromboembolism in children with acute lymphoblastic leukemia
    2 Year, New Annual (Pending), $45,351
  • Austin, Richard C. (McMaster University)
    Role of the sterol regulatory element-binding proteins in foam cell formation and atherogenesis
    3 Year, New Annual, $93,837
  • Austin, Richard C. (McMaster University)
    Inhibition of tissue factor procoagulant activity by GRP78 and its role in thrombosis
    3 Year, Renewal, $84,991
  • Belik, Jaques (Hospital for Sick Children)
    ENOS uncoupling and role of bone morphogenetic protein-9 in the regulation of pulmonary vascular tone during development and following pulmonary hypertension
    2 Year, New Annual (Pending), $86,906
  • Bendeck, Michelle P. (University of Toronto)
    Discoidin domain receptors (DDR1) in atherosclerosis
    2 Year, New Annual, $84,860
  • Bolz, Steffen-Sebastian (University of Toronto)
    Mechanisms that regulate the pressure-dependent activation of the sphingosine-1-phosphate signalling pathway in resistance arteries
    2 Year, New Annual (Pending), $70,190
  • Boughner, Derek R. (University of Western Ontario)
    Aortic sclerosis in an animal model: progression, regression and evaluation
    1 Year, Renewal, $69,918
  • Cepinskas, Gediminas (Lawson Health Research Institute)
    Cerebrovascular endothelial cell dysfunction in sepsis: role of astrocytes
    2 Year, New Annual, $81,883
  • Chan, Anthony K.C. (McMaster University)
    Surface mechanisms of anticoagulant ATH complex
    4 Year, Renewal, $84,450
  • Chauhan, Vijay S. (University Health Network)
    Characterizing ventricular repolarization alternans in human cardiomyopathy
    3 Year, Renewal (Pending), $84,004
  • Cheung, Angela M. (University Health Network)
    The role of vitamin K in aortic calcification in postmenopausal women: an exploratory analysis
    1 Year, New Annual (Pending), $60,166
  • Cote, Graham P. (Queen's University)
    Formation and function of invadopodia in vascular smooth muscle cells
    5 Year, Renewal, $88,919
  • Crowther, Mark A. (McMaster University)
    Evaluating the incidence and clinical importance of heparin induced thrombocytopenia in the critically ill
    3 Year, New Annual (Pending), $28,172
  • Cybulsky, Myron I. (University Health Network)
    Initiation of atherosclerosis: mechanisms and cell biology
    5 Year, Career Investigator
  • Cybulsky, Myron I. (University Health Network)
    Monocyte recruitment in atherosclerosis
    3 Year, Renewal, $115,560
  • Cybulsky, Myron I. (University Health Network)
    Regional differences in the arterial intima that predispose the artery wall to atherogenesis
    2 Year, Renewal (Pending), $102,606
  • Drangova, Maria (Robarts Research Institute)
    Cardiac imaging for therapy guidance and pre-clinical research studies
    5 Year, Career Investigator
  • Dumont, Daniel J. (Sunnybrook Health Sciences Centre)
    Molecular studies examining the role of lymphangiogenic signalling in heart disease
    3 Year, Renewal (Pending), $84,900
  • Epand, Richard M. (McMaster University)
    Development of potent antiatherogenic peptides
    3 Year, New Annual, $79,250
  • Feldman, Ross D. (Robarts Research Institute)
    Determinants of adenylyl cyclase mediated vascular responses
    2 Year, New Annual, $109,499
  • Feldman, Ross D. (Robarts Research Institute)
    Acute vascular effects of aldosterone
    2 Year, New Annual, $76,550
  • Feng, Qingping (Lawson Health Research Institute)
    Cardioprotection by erythropoietin: role of nitric oxide
    5 Year, Renewal (Pending), $119,732
  • Ferguson, Alastair (Queen's University)
    Adiponectin actions in autonomic control centres of the brain
    5 Year, Renewal (Pending), $118,707
  • Finestone, Hillel M. (Ottawa Health Research Institute)
    Driving post-stroke: a prospective study of community integration and driving habits
    1 Year, Renewal (Pending), $39,279
  • Gaisano, Herbert Y. (University of Toronto)
    SNARE regulation of cardiac sulfonylurea receptor. a novel drug target for cardiac ischemia
    4 Year, Renewal (Pending), $99,717
  • Gao, Yu-Jing (McMaster University)
    Perivascular adipose tissue, reactive oxygen species and hypertension
    2 Year, New Annual (Pending), $73,000
  • Gilbert, Richard E. (St. Michael's Hospital)
    Pathogenetic role of protein kinase c-beta in diabetic cardiomyopathy: interventional and translational studies
    2 Year, New Annual (Pending), $87,591
  • Ginsberg, Jeffrey S. (McMaster University)
    Diagnosis and management of thromboembolic disorders in multiple patient populations
    3 Year, Career Investigator
  • Gorczynski, Reginald M. (University Health Network)
    Regulation of transplant rejection and inflammation in CD200tg and CD200R KO mice
    3 Year, New Annual, $90,400
  • Gotlieb, Avrum I. (University Health Network)
    Cell biology of heart valve interstitial cells
    2 Year, New Annual, $88,780
  • Graham, Charles H. (Queen's University)
    Mechanisms regulating the development and pathophysiology of pre-eclamptic hypertension
    3 Year, Renewal, $94,943
  • Gros, Robert (Robarts Research Institute)
    Regulators of G-protein-coupled receptor-mediated vascular responses
    2 Year, New Annual (Pending), $71,295
  • Gross, Gil J. (Hospital for Sick Children)
    Ventricular repolarization in bradycardic electrical remodeling
    3 Year, Renewal (Pending), $86,914
  • Gross, Peter L. (St. Michael's Hospital)
    Defining how atorvastatin inhibits platelets
    2 Year, New Annual, $71,266
  • Grover, Ashok K. (McMaster University)
    Effects of reactive oxygen on Na-Ca exchange in coronary artery
    3 Year, Renewal (Pending), $102,017
  • Gupta, Radhey S. (McMaster University)
    Studies on mammalian adenosine kinase and its inhibitors
    3 Year, Renewal (Pending), $87,602
  • Haas, Tara L. (York University)
    The regulation of angiogenic factors by shear stress
    2 Year, New Annual (Pending), $79,750
  • Hache, Robert J.G. (Ottawa Health Research Institute)
    Regulation of preadipocyte differentiation by glucocorticoids in model systems
    3 Year, New Annual, $77,014
  • Harper, Mary-Ellen (University of Ottawa)
    Novel AMPK-gamma mutations in humans: implications for skeletal muscle energy metabolism
    3 Year, New Annual (Pending), $93,725
  • Hegele, Robert A. (Robarts Research Institute)
    Genomics of hypertriglyceridemia
    2 Year, New Annual (Pending), $108,208
  • Hegele, Robert A. (Robarts Research Institute)
    Phenomics and genomics of atherosclerosis in monogenic metabolic syndrome
    5 Year, Renewal, $109,999
  • Huff, Murray W. (Robarts Research Institute)
    Regulation of hepatic lipoprotein secretion and glucose homeostasis by the citrus flavonoid nobiletin: relationship to atherosclerosis
    2 Year, New Annual (Pending), $91,794
  • Jankov, Robert P. (Sunnybrook Health Sciences Centre)
    Rho-kinase inhibitors as therapy for chronic neonatal pulmonary hypertension
    2 Year, New Annual, $80,750
  • Karmazyn, Morris (University of Western Ontario)
    Role of adenosine in myocardial hypertrophy and heart failure
    3 Year, New Annual (Pending), $93,833
  • Kawaja, Michael David (Queen's University)
    Evaluating phenotypic changes in cerebral vessels of stroke-prone spontaneously hypertensive rats: a pilot proteomic investigation
    2 Year, New Annual (Pending), $66,762
  • Langille, B. Lowell (University Health Network)
    Arterial responses to hemodynamic stresses
    3 Year, Renewal (Pending), $89,518
  • Langille, B. Lowell (University Health Network)
    Cadherins and regulation of smooth muscle cell function
    5 Year, Renewal (Pending), $105,053
  • Levin, Mindy F. (University of Ottawa)
    Optimizing arm motor recovery in stroke
    3 Year, New Annual (Pending), $41,762
  • Li, Ren-Ke (University Health Network)
    Matrix modulation is required to restore cardiac function after cell therapy
    2 Year, Renewal (Pending), $91,243
  • Marcel, Yves L. (University of Ottawa Heart Institute)
    Macrophage lipid transporters and in vivo reverse cholesterol transport
    2 Year, New Annual (Pending), $88,500
  • Maurice, Donald H. (Queen's University)
    cAMP-signaling complexes in human vascular endothelial cells: studies on the impact of their numbers, composition and subcellular distribution on cAMP-regulated cellular functions
    2 Year, New Annual (Pending), $83,005
  • McCulloch, Christopher A. (University of Toronto)
    Regulation of myofibroblast differentiation by mechanical loading
    3 Year, Renewal, $97,021
  • McPherson, Ruth (University of Ottawa Heart Institute)
    Genetic determinants of HDL-C
    3 Year, New Annual (Pending), $133,182
  • Medin, Jeffrey A. (University Health Network)
    Enhancement of gene transfer outcomes for Fabry disease
    3 Year, New Annual (Pending), $125,247
  • Melo, Luis Gabriel (Queen's University)
    Cell-based gene therapy strategy to enhance neovascularization and healing of infarcted myocardium
    2 Year, Renewal (Pending), $97,228
  • Miller, Judith A. (University Health Network)
    Glomerular hemodynamic modulation in type 1 diabetes mellitus
    2 Year, New Annual (Pending), $62,614
  • Milne, Ross W. (University of Ottawa Heart Institute)
    Advanced glycation end products and diabetic atherosclerosis
    3 Year, Renewal (Pending), $71,677
  • Morris, Catherine E. (Ottawa Health Research Institute)
    The mechanosensitivity of pacemaker channels
    3 Year, New Annual (Pending), $80,914
  • Nag, Sukriti (University Health Network)
    Regulation of cerebrovascular homeostasis and repair by angiogenic factors
    2 Year, Renewal (Pending), $87,839
  • O'Donnell, Martin J. (McMaster University)
    INTERSTROKE; Importance of conventional and emerging risk factors for stroke in different regions of the world and in different ethnic groups: A pilot case-control study
    3 Year, New Annual (Pending), $105,750
  • Ofosu, Frederick A. (McMaster University)
    Platelet-derived serine proteases and platelet activation
    2 Year, Renewal (Pending), $70,398
  • Opas, Michal J. (University of Toronto)
    Calreticulin: cell and developmental biology
    3 Year, Renewal (Pending), $110,150
  • Opavsky, Mary Anne (Hospital for Sick Children)
    Heart failure and the coxsackie-adenovirus receptor (CAR): insights through a novel heart targeted CAR transgenic mouse
    3 Year, Renewal (Pending), $92,080
  • Pang, Stephen C. (Queen's University)
    Hypoxia inducible expression of atrial natriuretic peptide: a potential preemptive therapy for myocardial infarction
    3 Year, Renewal (Pending), $85,014
  • Parker, John D. (Mount Sinai Hospital)
    Clinical studies concerning nitrate pharmacology and autonomic physiology in congestive heart failure
    5 Year, Career Investigator
  • Parkinson, John (Hospital for Sick Children)
    A combined theoretical/experimental approach to understanding sequence-structure-function relationships in elastin
    2 Year, Renewal, $57,400
  • Radisic, Milica (University of Toronto)
    Peptide modified photocrosslinkable chitosan for cell therapy in myocardial infarction
    3 Year, New Annual (Pending), $50,974
  • Rand, Margaret L. (Hospital for Sick Children)
    The procoagulant surface of activated platelets: persistence in vitro and in vivo
    3 Year, Renewal (Pending), $85,803
  • Reid, Robert D. (University of Ottawa Heart Institute)
    A program to reduce cardiovascular risk among family members of patients with coronary heart disease
    3 Year, New Annual (Pending), $100,343
  • Reid, Robert D. (University of Ottawa Heart Institute)
    Efficacy and cost-effectiveness of behavioural counselling for exercise behaviour in men and women following AMI and PCI
    2 Year, Renewal (Pending), $74,641
  • Roberts, Robert (University of Ottawa Heart Institute)
    Genome-wide scan to identify coronary artery disease genes
    3 Year, New Annual (Pending), $118,612
  • Robinson, Lisa A. (Hospital for Sick Children)
    Regulation of the membrane-anchored chemokine, fractalkine, by thromboxane A2
    3 Year, Renewal, $88,868
  • Rochon, Elizabeth A (University of Toronto)
    Understanding the behavioural, neural and communicative changes underlying the treatment for anomia in aphasia
    2 Year, Renewal (Pending), $89,170
  • Rodger, Marc A. (Ottawa Health Research Institute)
    Thrombophilia and placenta mediated pregnancy complications
    5 Year, Career Investigator
  • Roy, Eric A. (University of Waterloo)
    Neuropsychological profiles and neuroanatomic correlates of limb apraxia
    5 Year, Renewal (Pending), $69,864
  • Rush, James W.E. (University of Waterloo)
    Vascular endothelium adaptations to hypertension and exercise
    2 Year, Renewal, $72,383
  • Sandig, Martin (University of Western Ontario)
    Integrin signaling in monocyte transendothelial migration
    2 Year, New Annual (Pending), $82,797
  • Simmons, Craig A. (University of Toronto)
    The role of extracellular matrix biomechanics in aortic valve sclerosis
    3 Year, New Annual (Pending), $81,125
  • Siu, Samuel C. (University Health Network)
    Neurodevelopmental outcomes in offsprings of women with heart disease
    2 Year, Renewal (Pending), $40,070
  • Slack, Ruth (Ottawa Health Research Institute)
    Mitochondrial dynamics in neuronal injury
    3 Year, New Annual, $88,247
  • Smith, Steven P. (Queen's University)
    Lipoprotein(a) in atherosclerosis: assembly and interaction with extracellular matrix proteins
    3 Year, Renewal, $87,856
  • Sorisky, Alexander (Ottawa Health Research Institute)
    Pro-atherogenic responses of human adipocytes to TSH
    3 Year, Renewal, $91,215
  • Spencer, Frederick A. (McMaster University)
    Clinical epidemiology and management of cardiovascular and venous thromboembolic disease
    5 Year, Career Investigator
  • Stewart, Duncan J. (St. Michael's Hospital)
    Role of angiopoietins in regulation of angiogenesis
    2 Year, New Annual (Pending), $67,734
  • Suskin, Neville (Lawson Health Research Institute)
    Comprehensive cardiac rehabilitation programming for patients following transient ischemic attack
    2 Year, New Annual (Pending), $126,586
  • Suuronen, Erik J. (University of Ottawa Heart Institute)
    Recruitment of endogenous circulating progenitor cells for cardiac regeneration using acellular tissue-engin biomatrices
    2 Year, New Annual, $89,098
  • Sweeney, Gary (York University)
    Direct effects of adiponectin on cardiomyocytes
    3 Year, Renewal (Pending), $73,500
  • Vaillancourt, Christian (Ottawa Health Research Institute)
    Effectiveness of dispatch-assisted CPR instructions: an evaluation of 9-1-1 calls
    3 Year, New Annual (Pending), $117,109
  • Van Arsdell, Glen S. (Hospital for Sick Children)
    The influence of postoperative systemic oxygen transport on neurologic outcomes in infants undergoing the No  (COMPLETE TITLE)??
    2 Year, New Annual, $59,000
  • Verma, Subodh (St. Michael's Hospital)
    ACE2: Novel regulator of endothelial function and atherosclerosis
    3 Year, New Annual (Pending), $104,058
  • Waddell, Thomas K (University Health Network)
    The role of galectin-3 in xenograft rejection
    3 Year, New Annual, $89,539
  • Wang, Hui Di (Brock University)
    Reactive oxygen species mediates angiotensin II induced ET-1 release from vascular adventitial fibroblasts
    2 Year, New Annual (Pending), $56,500
  • Warkentin, Theodore E. (McMaster University)
    Heparin-induced thrombocytopenia
    3 Year, Renewal (Pending), $99,894
  • Weisel, Richard D. (University Health Network)
    Cardiac regeneration: improving the response to injury
    3 Year, Renewal (Pending), $73,602
  • Wen, Xiao-Yan (University Health Network)
    Investigation of lysophospatidic acid (LPA) generation and platelet function in newly developed lpdlr phospholipase deficient mice
    2 Year, New Annual, $91,209
  • Werstuck, Geoffrey H. (McMaster University)
    Investigating the role of glycogen synthase kinase (GSK)-3 in atherogenesis
    3 Year, Renewal (Pending), $82,914
  • Wijeysundera, Duminda N. (University Health Network)
    The EPIC (evaluating perioperative ischemia reduction by clonidine) study: a randomized, triple-blinded, placebo-controlled trial of combining clonidine with chronic beta-blockade in intermediate-to- high risk non-cardiac surgery
    2 Year, New Annual (Pending), $92,443
  • Yang, Kaiping (University of Western Ontario)
    Early-life origins of visceral adiposity
    2 Year, New Annual (Pending), $81,921
  • Yao, Zemin (University of Ottawa Heart Institute)
    Interrelationship between hepatic lipase expression, proinflammatory cytokines, and HDL metabolism
    3 Year, Renewal (Pending), $84,679
  • Yao, Zemin (University of Ottawa)
    Analysis of non-truncation apoB mutations associated with human familial hypobetalipoproteinemia
    3 Year, Renewal (Pending), $80,920
  • Zandstra, Peter W. (University of Toronto)
    Controlling bioreactor condition to optimize regenerative potential of cardiomyocytes
    2 Year, New Annual (Pending), $87,850
  • Zhang, Zhu-Xu (Lawson Health Research Institute)
    Therapeutic potential and mechanism of double-negative regulatory T (DN-Treg) cells mediated tolerance in heart transplantation
    2 Year, New Annual (Pending), $78,294
  • Zimmerman, Deborah L. (Ottawa Health Research Institute)
    Control of hypertension in end stage renal disease, a randomized cross-over study comparing daily hemofiltration to conventional hemodialysis
    2 Year, New Annual (Pending), $56,325