Grant-in-Aid (GIA) and Career Investigator Competitions - Competition Results September 2009

The Heart and Stroke Foundation of Ontario is pleased to announce the results of the September 2009 Grant-in-Aid and Career Investigator competitions. 

Of the 258 GIA applications received, 90 were offered funding by the HSFO Grants Allocation Committee. The competition results posted below are to be considered preliminary only. An official letter will be sent to all applicants the week of March 22, 2010, along with the budget / funding details and rankings. 
The list provides the name of the principal investigator, institution, title, type of grant, first-year operating budget, term of the grant, and whether any condition has been placed on approval of the grant. For those awards identified as "pending", funding is encumbered until additional information is provided. This will be addressed in the letters to applicants noted above. This list is for information only. 
Career Investigator awards do not have first year amounts, however the standard stipend applies. 
The Foundation requests that applicants do not write or telephone with any enquiries before receiving the award letters. 
  • Adeli, Khosrow (Hospital for Sick Children)
    Mechanisms of intestinal lipoprotein overproduction in insulin resistant states
    3 Year, New Annual (Pending), $118,500
  • Anand, Sonia (McMaster University)
    South asian heart and health risk assessment project
    2 Year, New Annual (Pending), $70,000
  • Anand, Sonia (McMaster University)
    Genome wide association study of metabolic syndrome traits among south asians
    2 Year, New Annual (Pending), $90,000
  • Attisano, Liliana (University of Toronto)
    The role of Foxh1 in heart development
    2 Year, New Annual (Pending), $68,920
  • Atzema, Clare (Sunnybrook Health Sciences Centre)
    Atrial Fibrillation in The Emergency Room:  the AFTER study
    2 Year, New Annual (Pending), $70,000
  • Bailey, David G. (Lawson Health Research Institute)
    Coffee - cardiovascular drug interactions
    2 Year, New Annual (Pending), $55,879
  • Beique, Jean-Claude (University of Ottawa)
    Trafficking of NMDA receptors during stroke
    2 Year, New Annual (Pending), $58,119
  • Bendeck, Michelle P. (University of Toronto)
    Cell adhesion signaling in the progression and complications of atherosclerosis
    5 Year, Career Investigator 
  • Bergeron, Richard (Ottawa Hospital Research Institute)
    Glycine and brain ischemia
    2 Year, New Annual (Pending), $57,720
  • Bolz, Steffen-Sebastian (University of Toronto)
    A novel cardiovascular role for the cystic fibrosis transmembrane conductance regulator (CFTR): a critical transporter in the sphingosine-1-phosphate degradation pathway
    2 Year, New Annual (Pending), $74,523
  • Cepinskas, Gediminas (London Health Sciences Centre)
    Paracellular and intracellular mechanisms of cerebrovascular endothelial cell dysfunction in sepsis
    3 Year, New Annual (Pending), $81,029
  • Chauhan, Vijay S. (University Health Network)
    Structural and functional determinants of T wave alternans in human cardiomyopathy
    3 Year, Renewal (Pending), $10,8501
  • Chidiac, Peter (University of Western Ontario)
    Mechanism of the protective effect of RGS2 in cardiac hypertrophy
    2 Year, Renewal (Pending), $75,970
  • Chretien, Michel (Ottawa Hospital Research Institute)
    PCSK9 in cholesterol homeostasis: The key role of phosphorylation and hormone status
    3 Year, New Annual (Pending), $85,197
  • Cook, Deborah J. (McMaster University)
    PE-METRICS: pulmonary embloism: methodology, epidemiology & treatment in critical care study
    1 Year, New Annual (Pending), $49,903
  • Crowther, Mark A. (McMaster University)
    HITEC (Heparin induced thrombocytopenia evaluation in critical care) - Renewal
    1 Year, Renewal (Pending), $58,430
  • Cunningham, Charles H. (Sunnybrook Health Sciences Centre)
    Metabolic Imaging with MRI for myocardial salvage
    2 Year, New Annual (Pending), $81,618
  • Cybulsky, Myron I. (University Health Network)
    Mechanisms of monocyte recruitment and intimal cell proliferation in atherosclerosis
    3 Year, Renewal (Pending), $112,148
  • Danckert, James A. (University of Waterloo)
    Rehabilitating unilateral neglect: contrasting prism adaptation with saccade adaptation
    2 Year, New Annual (Pending), $48,760
  • Davies, Peter L. (Queen's University)
    Calcium-activated proteases in health and disease
    3 Year, 
    New Annual (Pending), $102,475
  • de Bold, Adolfo J. (University of Ottawa Heart Institute)
    Studies on cardiac structure and function post myocardial infarction following administration of a long acting ANF analogue
    2 Year, New Annual (Pending), $64,960
  • de Bold, Adolfo J. (University of Ottawa Heart Institute)
    Regulation of the endocrine function of the heart
    2 Year, New Annual (Pending), $60,360
  • Drucker, Daniel J. (Mount Sinai Hospital)
    Incretin action and the cardiovascular system
    3 Year, New Annual (Pending), $109,100
  • Dumont, Daniel J. (Sunnybrook Health Sciences Centre)
    Examination of the novel angiopoietin peptide mimetic vasculotide as a treatment for atherosclerosis and limb ischemia
    2 Year, New Annual (Pending), $83,000
  • Dumont, Daniel J. (Sunnybrook Health Sciences Centre)
    Molecular studies examining the role of lymphangiogenic signalling heart disease
    3 Year, Renewal (Pending), $91,000
  • Epand, Richard M. (McMaster University)
    Mechanism of action of potent antiatherogenic peptides
    2 Year, Renewal (Pending), $65,000
  • Eubanks, James H. (University Health Network)
    The mammalian sirtuin SIRT3: novel neuroprotective factor
    2 Year, New Annual (Pending), $76,619
  • Feng, Qingping (University of Western Ontario)
    Mechanisms of heart failure
    5 Year, Career Investigator
  • Fremes, Stephen E. (Sunnybrook Health Sciences Centre)
    Surgical and pharmacological novel intervention to improve overall results of saphenous vein graft patency in coronary artery bypass grafting surgery: An international multi-centre randomized controlled clincial trial (Superior SVG Patency CABG trial)
    3 Year, N
    ew Annual (Pending), $65,860
  • Friedberg, Mark K. (Hospital for Sick Children)
    Ventricular-ventricular interactions and their modulation for enhancement of right ventricular performance in pulmonary arterial hypertension
    2 Year, New Annual (Pending), $65,741
  • Goldfield, Gary S. (Children's Hospital of Eastern Ontario)
    Behavioural engineering of physical activity in obese children: a randomized controlled trial
    2 Year, New Annual (Pending), $80,558
  • Gorczynski, Reginald M. (University Health Network)
    Regulation of transplant rejection and inflammation by soluble mediators of CD200:CD200R interaction
    3 Year, Renewal (Pending), $89,314
  • Grinstein, Sergio (Hospital for Sick Children)
    Role of macrophage CD36 in atherosclerosis
    3 Year, Renewal (Pending), $110,360
  • Gruenwald, Colleen (Hospital for Sick Children)
    Antithrombin enhancement may improve anticoagulation efficiency in infants undergoing cardiopulmonary bypass for cardiac surgery
    2 Year, New Annual (Pending), $70,000
  • Haas, Tara L. (York University)
    Roles of protease inhibitors in skeletal muscle microvascular remodelling
    3 Year, New Annual (Pending), $80,660
  • Harper, Mary-Ellen (University of Ottawa)
    Implications of AMPK-gamma mutations for cardiac and skeletal muscle mitochondrial energetics
    3 Year, Renewal (Pending), $95,180
  • Hayward, Catherine P. (McMaster University)
    Studies of novel platelet secretory proteins
    2.5 Year, Career Investigator
  • Hinz, Boris (University of Toronto)
    Mechanical activation of a pro-fibrotic growth factor in cardiac myofibroblast differentiation and heart fibrosis
    2 Year, New Annual (Pending), $75,500
  • Huff, Murray W. (University of Western Ontario)
    Regulation of ApoB metabolism: relationship to atherosclerosis
    3 Year, Renewal (Pending), $132,760
  • Ikura, Mitsuhiko (University Health Network)
    Structural basis for regulation of store-operated calcium entry in the circulation system
    3 Year, New Annual (Pending), $113,400
  • Kanelis, Voula (University of Toronto)
    Studies of the molecular mechnisms by which mutations in the SUR2A NBDs cause cardiovascular diseases
    2 Year, New Annual (Pending), $77,000
  • Karmazyn, Morris (University of Western Ontario)
    Nitric oxide as an endogenous antihypertrophic factor
    2 Year, New Annual (Pending), $75,700
  • Karmazyn, Morris (University of Western Ontario)
    Role of adenosine in myocardial hypertrophy and heart failure
    2 Year, Renewal (Pending), $83,488
  • Kassner, Andrea (Hospital for Sick Children)
    Widening the therapeutic window in acute ischemic stroke with blood-brain barrier permeability imaging and its relationship with corresponding blood markers: implications for short and long-term outcomes
    2 Year, New Annual (Pending), $68,245
  • Kelton, John G. (McMaster University)
    Platelet-mediated acute thrombotic disorders
    3 Year, Renewal (Pending), $145,887
  • Ko, Dennis T. (Sunnybrook Health Sciences Centre)
    Assessing the appropriateness of coronary revascularization for patients with coronary artery disease
    2 Year, New Annual (Pending), $87,792
  • Kuebler, Wolfgang (St. Michael's Hospital)
    Mast cells in vascular remodeling and pulmonary hypertension with left heart disease
    2 Year, New Annual (Pending), $78,200
  • Le Foll, Bernard (Centre for Addiction and Mental Health)
    Role of ethanolamides in nocitine-seeking
    2 Year, 
    New Annual (Pending), $70,000
  • Letarte, Michelle V. (Hospital for Sick Children)
    Soluble endoglin in endothelial cell function and hypertension associated with preeclampsia
    3 Year, New Annual (Pending), $116,580
  • Lillicrap, David (Queen's University)
    Age-related pathophysiology of von Willebrand factor
    2 Year, New Annual (Pending), $72,635
  • Liu, Peter P. (University Health Network)
    Danger signal, innate immunity and cardiovascular inflammation
    2 Year, Renewal (Pending), $75,460
  • Logan, Alexander G. (Mount Sinai Hospital)
    Disturbed sleep and drug resistant hypertension:  a pathophysiological study
    2 Year, Renewal (Pending), $59,729
  • MacLennan, David H. (University of Toronto)
    Calcium perturbation, ER stress and the pathogenesis of dilated cardiomyopathy
    3 Year, New Annual (Pending), $123,600
  • Maunder, Robert G. (Mount Sinai Hospital)
    The impact of close interpersonal relationships and social support on heart failure
    3 Year, New Annual (Pending), $104,020
  • McCulloch, Christopher A.G. (University of Toronto)
    Regulation of myofibroblast differentitation by mechanical loading
    3 Year, Renewal (Pending), $94,200
  • McDermott, John C. (York University)
    Regulation of vascular smooth muscle gene expression by MEF2
    3 Year, New Annual (Pending), $92,136
  • McDermott, John C. (York University)
    Regulation of MEF2 in cardiac and skeletal muscle cells
    3 Year, New Annual (Pending), $93,500
  • McGuigan, Alison P. (University of Toronto)
    Exploiting planar cell polarity signaling to engineer tissue-engineered blood vessels
    3 Year, New Annual (Pending), $77,400
  • Mielniczuk, Lisa M. (University of Ottawa Heart Institute)
    Right ventricular substrate metabolism as a predictor of right heart failure in patients with pulmonary arterial hypertension
    2 Year, New Annual (Pending), $66,469
  • Min, Wei-Ping (London Health Sciences Centre)
    Preventing heart graft rejection through interrupting CD40-CD40L pathway by cell-specific gene silencing
    2 Year, Renewal (Pending), $71,010
  • Monnier, Philippe P. (University Health Network)
    Repulsive guidance molecule (RGMa) has multiple inhibitory activities that hamper neuronal regeneration after stroke
    2 Year, New Annual (Pending), $59,180
  • Nanthakumar, Kumaraswamy (University Health Network)
    Modulation of spatio-temporal dispersion of human myocardial repolarization by air pollution
    3 Year, New Annual (Pending), $92,565
  • Nesheim, Michael E. (Queen's University)
    The activation of TAFI and the properties of TAFIa
    3 Year, Renewal (Pending), $88,521
  • O'Brien, Edward R.M. (University of Ottawa Heart Institute)
    Novel vascular therapeutic effects of heat shock protein 27
    2 Year, New Annual (Pending), $48,481
  • O'Donnell, Martin J. (McMaster University)
    Sodium intake and cardiovascular disease in diverse populations
    3 Year, New Annual (Pending), $105,256
  • Pare, Guillaume (McMaster University)
    Understanding the contribution of genetic variants to stroke risk in a multi-ethnic population: the interstroke genetics study
    3 Year, New Annual (Pending), $118,669
  • Pickering, J. Geoffrey (University of Western Ontario)
    Control of smooth muscle cell motility and vascular stabilization
    3 Year, Renewal (Pending), $122,530
  • Pipe, Andrew L. (University of Ottawa Heart Institute)
    Self directed titrated nicotine patch versus standard treatment for smoking cessation in smokers motivated to quit
    3 Year, New Annual (Pending), $125,000
  • Prasad, Ramesh (St. Michael's Hospital)
    Impact of minimal steroid-based kidney transplantation on ventricular remodeling and function in end-stage renal disease
    3 Year, New Annual (Pending), $78,101
  • Radisic, Milica (University of Toronto)
    Chitosan hydrogel with immobilized growth factors for cell therapy in myocardial infarction
    3 Year, Renewal (Pending), $70,216
  • Rand, Margaret L. (Hospital for Sick Children)
    The procoagulant surface of activated platelets: development and persistence in vitro and in vivo
    2 Year, Renewal (Pending), $79,821
  • Rochon, Elizabeth A (University of Toronto)
    The effects of intensity on a treatment for naming deficits in aphasia and associated neural underpinnings
    3 Year, 
    New Annual (Pending), $86,304
  • Rodger, Marc A. (Ottawa Hospital Research Institute)
    GENErVTE: GEne-GeNE interactions and recurrent venous thromboembolism
    1 Year, New Annual (Pending), $44,899
  • Ruzicka, Marcel (University of Ottawa)
    Sympathetic activity in patients with end-stage renal disease on peritoneal dialysis
    2 Year, New Annual (Pending), $54,552
  • Silversides, Candice K. (University Health Network)
    Investigation of the prognostic importance of natriuretic peptides in pregnant women with heart disease: a prospective observational cohort study
    2 Year, 
    Renewal (Pending), $69,970
  • Simmons, Craig A. (University of Toronto)
    Regulation of aortic valve calcification by matrix biomechanics
    3 Year, Renewal (Pending), $102,431
  • Slack, Ruth (University of Ottawa)
    Manipulating mitochondrial dynamics to promote brain recovery after stroke
    3 Year, Renewal (Pending), $102,384
  • Sorisky, Alexander (Ottawa Hospital Research Institute)
    Atherogenic adipocyte dysfunction induced by TSH
    2 Year, Renewal (Pending), $80,084
  • Stiell, Ian G. (Ottawa Hospital Research Institute)
    A prospective evaluation of the outcomes and quality of life of emergency department patients with recent-onset atrial fibrillation and flutter (RAFF)
    3 Year, New Annual (Pending), $100,743
  • Sweeney, Gary (York University)
    Cardioprotective effects of adiponectin
    3 Year, Renewal (Pending), $80,000
  • Teo, Koon K. (McMaster University)
    Early life origins of obesity and obesity-related disorders- the family cohort
    3 Year, New Annual (Pending), $158,133
  • Tu, Jack V. (Sunnybrook Health Sciences Centre)
    Improving the quality of cardiovascular care in Canada
    5 Year, Career Investigator
  • Tymianski, Michael (University Health Network)
    Role of TRM7 channels in myocardial ischemia
    3 Year, New Annual (Pending), $115,440
  • Tymianski, Michael (University Health Network)
    Differential gene response to cerebral ischemia in rats and non-human primates
    2 Year, New Annual (Pending), $75,000
  • Van Arsdell, Glen S. (Hospital for Sick Children)
    Mechanical lung assist as a means to achieve primary in-series palliation for single ventricle neonates: a proof of concept study in neonates and infants
    2 Year, New Annual (Pending), $38,055
  • Wang, Hao (University of Western Ontario)
    Mechanisms of immunomodulation by mesenchymal cells in cardiac allograft tolerance
    2 Year, New Annual (Pending), $85,371
  • Warkentin, Theodore E. (McMaster University)
    Heparin-induced thrombocytopenia
    3 Year, Renewal (Pending), $98,196
  • Weitz, Jeffrey I. (McMaster University)
    Effect of histidine-rich glycoprotein on coagulation and fibrinolysis
    3 Year, Renewal (Pending), $116,258
  • Wells, R. Glenn (University of Ottawa Heart Institute)
    Respiratory motion compensation in coronary flow reverse measurements with CZT dedicated cardiac single-photon emission computed tomography
    2 Year, New Annual (Pending), $78,254
  • Werstuck, Geoffrey H. (McMaster University)
    Investigating the role of glycogen synthase kinase (GSK)-3 in accelerated atherosclerosis
    2 Year, Renewal (Pending), $81,000
  • Wilson, Gregory J. (Hospital for Sick Children)
    Remote ischemic preconditioning: mechanisms of cardiomyocyte survival
    2 Year, New Annual (Pending), $73,560
  • Yao, Zemin (University of Ottawa)
    Functional analysis of ApoC3 mutation in human hypotriglyceridemia
    3 Year, New Annual (Pending), $90,584
  • Yao, Zemin (University of Ottawa)
    Analysis of non-truncating APOB mutations in human hypobetalipoproteinemia and hypocholesterolemia
    2 Year, Renewal (Pending), $71,200
  • Zha, Xiaohui (Ottawa Hospital Research Institute)
    Molecular mechanisms of calcineurin signaling in ABCA1 function
    3 Year, Renewal (Pending), $84,500