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Heart and Stroke Foundation of Ontario Release of Funds for Existing Multi-Year Research Grants and Personnel Awards for the term of July 1, 2010 to June 30, 2011 The Heart and Stroke Foundation of Ontario is pleased to announce confirmation of budget commitment on existing multi-year grants-in-aid and personnel awards as indicated below. An official letter will also be sent to all grant recipients shortly. For those awards identified as "pending", funding is encumbered until additional information is provided.   Additionally, for projects that were identified as being "applied" or "clinically oriented" in the September 2008 competition, funding is encumbered pending receipt and approval of the May 15, 2010 Progress Report. For all other awards, please refer to your award letter for details.  September 2009 Competition Funding Decisions The funding decisions for the September 2009 competition will be announced by March 15, 2010 on the national website www.hsf.ca/research. Adams, Michael A.  Queen's University Antihypertensive treatment strategies in the management of sexual dysfunction TYPE 2008 Renewal $ 100 823 Adeli, Khosrow  Hospital for Sick Children Molecular mechanisms of hepatic VLDL overproduction in insulin resistance TYPE 2007 Renewal (Pending) $ 143 012 Adeli, Khosrow  Hospital for Sick Children Molecular mechanisms of apolipoprotein B degradation TYPE 2009 Renewal $ 135 422 Alter, David A.  St. Michael's Hospital Cardiovascular treatment & outcomes disparities among high-risk populations TYPE 2006 Career Investigator $ 87 950 Andrew, Robert David  Queen's University Mechanisms that drive acute neuronal swelling and dysfunction in stroke TYPE 2009 Renewal $ 84 921 Assini, Julia  University of Western Ontario Prevention of dyslipidemia and atherosclerosis by the citrus flaveonoid, nobiletin TYPE 2009 Master's Studentship (Pending) $ 18 500 Austin, Peter C.  Sunnybrook Health Sciences Centre Statistical methods for cardiovascular research TYPE 2008 Career Investigator $ 87 950 Austin, Richard C.  McMaster University Role of endoplasmic reticulum stress in atherothrombotic disease TYPE 2006 Career Investigator $ 87 950 Austin, Richard C.  McMaster University Contributions of the unfolded protein response pathway to adipogenesis and obesity TYPE 2008 New Annual $ 79 234 Austin, Richard C.  McMaster University Identification and characterization of novel and therapeutic strategies that decrease atherothrombotic disease TYPE 2008 Program (Pending) $ 250 000 Backx, Peter H.  University Health Network Transcriptional regulation of cardiac transient outward K+ currents and function in heart TYPE 2008 Renewal $ 142 096 Backx, Peter H.  University of Toronto Studies into molecular mechanisms of cardiovascular disease TYPE 2009 Career Investigator $ 87 950 Beanlands, Rob S. B.  University of Ottawa Heart Institute Metabolism, energetics and neurohormonal signaling and their response to therapy in dysfunctional myocardium TYPE 2008 Career Investigator $ 87 950 Beanlands, Rob S. B.  University of Ottawa Heart Institute Elucidation of metabolic and cellular function alterations in dysfunctional myocardium and their response to therapy TYPE 2007 Program (Pending) $ 249 989 Beattie, William S.  University Health Network The ENIGMA-II trial. Nitrous oxide anaesthesia and cardiac morbidity after major surgery: a randomized controlled trial TYPE 2009 New Annual (Pending) $ 80 000 Beca, Bogdan Mihai  University of Toronto High-throughput screening of heart valve tissue engineering systems TYPE 2009 Master's Studentship (Pending) $ 18 500 Bendeck, Michelle P.  University of Toronto Cadherins and regulation of smooth muscle cell function TYPE 2007 Renewal (Pending) $ 126 995 Bendeck, Michelle P.  University of Toronto Discoidin domain receptors in atherosclerosis TYPE 2009 Renewal $ 140 500 Bolz, Steffen-Sebastian  University of Toronto Mechanisms that regulate the pressure-dependent activation of sphingosine kinase 1 in resistance artery smooth muscle cells TYPE 2009 Renewal $ 80 916 Bonen, Arend  University of Guelph Regulation of fatty acid transport in the heart TYPE 2006 Renewal $ 99 022 Brooks, Dina  University of Toronto Effect of cardiac rehabilitation for individuals after transient ischemic attack TYPE 2009 New Annual (Pending) $ 80 000 Cameron, Jill I.  University of Toronto Optimizing stroke family caregiver support across the care continuum by improving the timing of intervention delivery TYPE 2009 New Annual (Pending) $ 104 661 Carrier, Marc  Ottawa Hospital Research Institute Screening for previously undiagnosed malignancy in patients with unprovoked venous thromboembolism: a randomized controlled trial using a comprehensive computed tomography of the abdomen/pelvis TYPE 2009 New Annual (Pending) $ 80 000 Cattral, Mark S.  University Health Network Role of immedate dendritic cell precursors in allograft rejection and tolerance TYPE 2008 New Annual $ 76 694 Chan, Anthony K.C.  McMaster University Carbohydrate variation effects in the protein C pathway during development TYPE 2008 New Annual $ 79 564 Chan, Anthony K.C.  McMaster University Surface mechanisms of anticoagulant ATH complex TYPE 2007 Renewal (Pending) $ 89 418 Chan, Christopher T.M.  University Health Network Towards an improved understanding of vascular progenitor cell biology in uremia TYPE 2009 New Annual (Pending) $ 65 703 Chen, Hsiao-Huei  Ottawa Hospital Research Institute Mechanisms to reduce injury and improve recovery from stroke TYPE 2008 New Annual $ 106 511 Cherney, David Z.I.  University Health Network Hemodynamic and molecular mechanisms of hyperfiltration in type I diabetes mellitus TYPE 2009 New Annual $ 78 795 Chidiac, Peter  University of Western Ontario Impact of RGS proteins on cardiovascular function TYPE 2008 Career Investigator $ 87 950 Ciriello, John  University of Western Ontario Leptin links obstuctive sleep apnea, obesity and hypertension TYPE 2008 New Annual $ 112 193 Connelly, Kim A.  St. Michael's Hospital Role of TGFb acetylation in the pathogenesis of diabetic cardiomyopathy TYPE 2009 Clinician Scientist $ 64 000 Connelly, Philip W.  St. Michael's Hospital Studies of the lactonase activity of paraoxonase 1 - an HDL associated enzyme of relevance to cardiovascular disease TYPE 2008 Renewal $ 80 000 Copeland, John W.  University of Ottawa Role of formin proteins in shear stress-induced cytoskeletal remodeling in endothelial cells TYPE 2008 Renewal $ 108 585 Cote, Graham P.  Queen's University Formation and function of invadopodia in vascular smooth muscle cells TYPE 2007 Renewal (Pending) $ 94 105 Cregan, Sean P.  Robarts Research Institute Mechanisms of P53 induced neuronal apoptosis TYPE 2008 New Annual $ 79 705 Crowther, Mark A.  McMaster University Reducing cardiovascular disease by improving our use of antithrombotic agents. TYPE 2009 Career Investigator $ 87 950 Crowther, Mark A.  McMaster University Does low dose oral vitamin K improve the quality of warfarin anticoagulation TYPE 2009 New Annual (Pending) $ 129 852 Cybulsky, Myron I.  University Health Network Initiation of atherosclerosis: mechanisms and cell biology TYPE 2007 Career Investigator (Pending) $ 87 950 Cybulsky, Myron I.  University Health Network Endothelial cell NF-kappaB homeostasis and function in atherosclerosis TYPE 2009 New Annual $ 124 266 Daneman, Denis  Hospital for Sick Children Adolescent type 1 Diabetes cardio-renal Intervention trial (AdDIT) TYPE 2009 New Annual $ 91 205 Davis, Darryl R.  University of Ottawa Heart Institute Mechanism of therapy: cardiac stem cells in myocardial repair TYPE 2009 Clinician Scientist $ 64 000 Dawson, John F.  University of Guelph Expression and characterization of human cardiac actin mutants linked to hypertrophic and dilated cardiomyopathies TYPE 2008 New Annual $ 79 556 Demers, Catherine  McMaster University The impact of mild cognitive deficits at hospital discharge on self-care in older heart failure patients TYPE 2009 New Annual (Pending) $ 98 092 Dick, Alexander J.  Sunnybrook Health Sciences Centre Endothelial progenitor cell modification to improve left ventricular function post myocardial infarction TYPE 2008 Clinician Scientist $ 70 250 Dick, Alexander J.  Sunnybrook Health Sciences Centre Endothelial progenitor cell modification to improve left ventricular function post myocardial infarction TYPE 2008 Renewal $ 78 008 Dorian, Paul  St. Michael's Hospital Studies of the effect of fish oil derived omega-3 Polyunsaturated fatty acids ( EPA and DHA), and omega-6 fatty acids on experimental atrial fibrillation, and mechanisms of their antiarrhythmic effects TYPE 2009 New Annual (Pending) $ 116 826 Dos Santos, Claudia C.  St. Michael's Hospital The Role of PGC1a in sepsis-induced myocardial depression TYPE 2008 Clinician Scientist $ 64 000 Drangova, Maria  Robarts Research Institute Cardiac imaging for therapy guidance and pre-clinical research studies TYPE 2007 Career Investigator (Pending) $ 87 950 Drangova, Maria  Robarts Research Institute Dynamic micro-CT for pre-clinical cardiac imaging TYPE 2008 Renewal $ 118 204 Egan, Mary  University of Ottawa Engaging in values activities post stroke TYPE 2009 New Annual (Pending) $ 47 287 Eikelboom, John W.A.  McMaster University Thrombotic mechanisms as predictors of Vascular events In non-cardiac Surgery patIents cohOrt evaluatioN (ThromboVISION) TYPE 2009 New Annual (Pending) $ 130 301 Emili, Andrew  University of Toronto Mechanistic investigation of microRNA-mediated regulation of dilated cardiomyopathy (DCM) TYPE 2008 New Annual $ 96 378 Fehlings, Michael G.  University Health Network The ischemic axon: cross-talk with myelin in K+ channel terms TYPE 2008 Renewal $ 84 389 Feldman, Ross D.  Robarts Research Institute Determinants of adenylyl cyclase-mediated vascular responses. TYPE 2009 Renewal $ 148 729 Feng, Qingping  London Health Sciences Centre Cardioprotection by erythropoietin: role of nitric oxide TYPE 2007 Renewal (Pending) $ 127 060 Feng, Qingping  University of Western Ontario Heart development in diabetes: role of nitric oxide TYPE 2009 New Annual (Pending) $ 123 206 Ferguson, Alastair V.  Queen's University Adiponectin actions in autonomic control centres of the brain TYPE 2007 Renewal (Pending) $ 124 688 Ferguson, Stephen G.  Robarts Research Institute Molecular regulation of G protein-coupled receptor signal transduction, desensitization and resensitization TYPE 2008 Career Investigator $ 87 950 Ferguson, Stephen G.  Robarts Research Institute Regulation of G protein-coupled receptor signaling desensitization and resensitization TYPE 2006 Renewal $ 126 523 Floras, John S.  University Health Network Neural regulation of the circulation in human heart failure and hypertension TYPE 2008 New Annual $ 134 406 Floras, John S.  University Health Network Central regulation of autonomic  cardiovascular function in human heart failure and sleep apnea TYPE 2008 New Annual $ 60 287 Fowler, Robert A.  Sunnybrook Health Sciences Centre Prospective economic analysis in the prophylaxis for thrombolism in critical care trail TYPE 2009 Clinician Scientist $ 70 250 Fowler, Robert A.  Sunnybrook Health Sciences Centre E-PROTECT: prospective economic analysis in the prophylaxis for thromboembolism in critical care trial TYPE 2008 New Annual $ 63 149 Funk, Colin D.  Queen's University Lipoxygenase and cyclooxygenase pathways in cardiovascular disease TYPE 2006 Career Investigator $ 87 950 Gagnon, France  University of Toronto Genome-wide search for oligogenes in factor V leiden thrombophilia TYPE 2008 Renewal $ 111 886 Gaisano, Herbert Y.  University of Toronto SNARE regulation of cardiac sulfonylurea receptor. A novel drug target for cardiac ischemia TYPE 2007 Renewal (Pending) $ 105 111 Giacca, Adria  University of Toronto Vasculoprotective effect of insulin in vivo TYPE 2008 Renewal $ 79 631 Giordano, Celine  University of Ottawa Functional comparison of circulating progenitor cell subpopulations for cell-based angiogenesis TYPE 2009 Master's Studentship (Pending) $ 18 500 Gladstone, David J.  Sunnybrook Health Sciences Centre Improving the detection and treatment of atrial fibrillation following transient ischemic attack and stroke TYPE 2009 Clinician Scientist $ 70 250 Gollob, Michael H.  University of Ottawa Heart Institute Insight into the mechanisms of atrial fibrillation TYPE 2009 Clinician Scientist $ 70 250 Grace, Sherry L.  University Health Network An RCT of women's adherence to women-only, home-based and traditional cardiac rehabilitation (Cardiac Rehabilitation for Her heart Event Recovery [CR4HER]) TYPE 2009 New Annual $ 108 179 Gramolini, Anthony O.  University of Toronto Investigation of phospholamban mutations, sarcoplasmic reticulum calcium defects, and dilated cardiomyopathy TYPE 2008 Renewal $ 98 597 Grant, David R.  University Health Network fgl2/FGL2 and xenograft transplantation TYPE 2008 Renewal $ 88 600 Gross, Peter L.  McMaster University Defining how atorvastatin inhibits platelets TYPE 2009 Renewal $ 80 000 Grover, Ashok K.  McMaster University Caloxins: novel inhibitors of plasma membrane calcium pumps TYPE 2008 Renewal $ 79 256 Gula, Lorne J.  University of Western Ontario Monitoring of Ventricular Rhythm & Exercise - ICD study (MOVE-IT). TYPE 2009 New Annual (Pending) $ 72 468 Hammond, James R.  University of Western Ontario   Role of nucleoside/nucleobase transporters in the regulation of the vascular effects of adenosine and its metabolites TYPE 2008 Renewal $ 78 637 Hayward, Catherine P.  McMaster University Functions of multimerin 1 as a platelet adhesive protein. TYPE 2009 Renewal $ 80 000 Heckman, George A.W.  McMaster University Adapting the Canadian Cardiovascular Society recommendations on heart failure: a consensus-based approach with stakeholder input TYPE 2009 New Annual (Pending) $ 79 788 Hegele, Robert A.  Robarts Research Institute Phenomics and genomics of atherosclerosis in monogenic metabolic syndrome TYPE 2007 Renewal (Pending) $ 112 436 Hegele, Robert A.  Robarts Research Institute Genomics of hypertriglyceridemia TYPE 2009 Renewal $ 164 036 Heximer, Scott P.  University of Toronto Defining the molecular pathways through which RGS4 regulates parasympathetic signaling and heart rate control in sinoatrial node myocytes TYPE 2009 Renewal $ 149 220 Hinek, Aleksander  Hospital for Sick Children Elastin and elastin receptor as crucial factors modulation cellular funtions in cardiovascular development and diseases TYPE 2008 Renewal $ 122 645 Holden, Rachel M.  Queen's University Mechanisms of vascular calcification (VC) in a model of chronic kidney disease (CKD) TYPE 2009 New Annual (Pending) $ 88 011 Holdsworth, David W.  Robarts Research Institute Investigation of flow in the stenosed carotid bifurcation TYPE 2008 Renewal $ 114 838 Hou, Sheng T.  University of Ottawa Investigation of SEMA3A's role in angiogenesis and vascular permeability during stroke recovery TYPE 2009 Renewal $ 72 575 Hough, Margaret R.  Sunnybrook Health Sciences Centre Cardiac repair and regeneration TYPE 2009 Renewal $ 80 000 Huff, Murray W.  Robarts Research Institute Cellular Programs and Responses in Atherosclerosis TYPE 2006 Program (Pending) $ 250 000 Husain, Mansoor  University Health Network Plasma membrane Ca2+ ATPase 4 isoforms: regulation and role in cardiac and smooth muscle TYPE 2009 New Annual (Pending) $ 118 118 Husain, Mansoor  University Health Network The role of glucagon-like peptide-1 in cardiac health and disease TYPE 2009 Renewal $ 142 380 Husain, Mansoor  University of Toronto Molecular studies of cardiac and vascular disease. TYPE 2009 Career Investigator $ 87 950 Ikura, Mitsuhiko  University Health Network Structural elucidation of intracellular calcium transporters TYPE 2006 Renewal $ 105 258 Karkouti, Keyvan  University Health Network Advance targeted transfusion in anemic cardiac surgical patients for kidney protection: a proof of concept pilot study. TYPE 2009 New Annual (Pending) $ 36 001 Kearon, Clive  McMaster University Optimizing treatment and diagnosis of venous thromboembolism TYPE 2008 Career Investigator $ 87 950 Keeley, Fred W.  Hospital for Sick Children Recombinantly expressed elastin-like polypeptides as a novel tool for investigations of the structure, assembly, and the properties of elastin-like materials TYPE 2009 Renewal $ 131 821 Keith, Mary E.  St. Michael's Hospital A randomized controlled trial of the effect of thiamin supplementation on heart function in ambulatory patients with heart failure TYPE 2009 New Annual (Pending) $ 126 849 Kelley, Beverley  University of Ottawa Navigating Community Care Post-Stroke: An Examination of Older Adults' Experiences TYPE 2009 Fellowship $ 31 000 Khokha, Rama  University Health Network   Molecular dissection of the distinct functions of TIMP-3 and TIMP-4 in heart disease TYPE 2009 Renewal $ 114 381 Kislinger, Thomas  University Health Network Identification and characterization of cell-surface associated protein in the heart : applications of a novel proteomic strategy TYPE 2009 New Annual $ 129 261 Koschinsky, Marlys L.  Queen's University The pathophysiology of Lp(a) in the arterial wall: effect of Apo(a) on vascular cell function TYPE 2006 Renewal $ 104 368 Koschinsky, Marlys L.  University of Windsor Mechanisms of atherothrombosis: analysis of lipoprotein and fibrinolytic risk factors TYPE 2006 Career Investigator $ 87 950 Koschinsky, Marlys L.  University of Windsor Modulation of the TAFI pathway in health and disease: mechanistic analysis of the regulation of TAFI gene expression in hepatic and extrahepatic cells TYPE 2008 New Annual $ 120 558 Krahn, Andrew D.  University of Western Ontario Inherited arrhythmias: clinical and genetic assessment of primary electrical disease TYPE 2008 Career Investigator $ 87 950 Krahn, Andrew D.  University of Western Ontario Inherited causes of sudden death: phenotype genotype correlation TYPE 2009 Renewal $ 170 089 Lagace, Thomas A.  University of Ottawa Heart Institute Regulation of the PCSK9 binding interaction with LDL receptor TYPE 2009 New Annual (Pending) $ 78 331 Lanctot, Krista L.  Sunnybrook Health Sciences Centre The role of cytokine-serotonin interactions in post-stroke depression and cognitive symptoms TYPE 2008 Renewal $ 94 587 Law, Sai Fai Bosco  McMaster University Improving effectiveness of cardiac resuscitation through high fidelity simulation and team training TYPE 2009 Master's Studentship (Pending) $ 18 500 Lee, Jonathan M.  University of Ottawa The role of elongation factor eEF1A2 in obesity TYPE 2008 New Annual $ 71 921 Lee, Ting-Yim  Lawson Health Research Institute Prediction of hemorrhagic transformation of ischemic stroke with CT perfusion derived blood-brain-barrier permeability surface area product TYPE 2009 New Annual $ 90 096 Leenen, Frans H.H.  University of Ottawa Heart Institute RAS blockade and sympathetic activity in humans post MI TYPE 2008 New Annual $ 110 881 Leong-Poi, Howard M.  St. Michael's Hospital Ultrasound-targeted gene and cell-based strategies for therapeutic angiogenesis TYPE 2008 Clinician Scientist $ 70 250 Leong-Poi, Howard M.  St. Michael's Hospital Role of statins in progenitor cell therapy for chronic ischemia TYPE 2009 New Annual (Pending) $ 74 868 Lewis, Gary F.  University Health Network The role of C-reactive protein (CRP) in modulating insulin action and insulin secretion TYPE 2008 New Annual $ 85 948 Lewis, Gary F.  University of Toronto Determining the mechanisms of the dyslipidemia of insulin resistant states and Type 2 diabetes TYPE 2008 Career Investigator $ 43 975 Leytin, Valery  St. Michael's Hospital Mitochondrial control of platelet apoptosis TYPE 2008 Renewal $ 99 489 Li, Ren-Ke  University Health Network Restoration of cardiac function: cellular regeneration and matrix reconstruction TYPE 2006 Career Investigator $ 87 950 Li, Ren-Ke  University Health Network Modifying cardiac repair using molecular and cellular interventions TYPE 2009 Renewal $ 80 000 Liaw, Patricia C.Y.  McMaster University Studies of the endothelial cell protein C receptor (EPCR) TYPE 2008 New Annual $ 121 160 Licht, Christoph P.B.  Hospital for Sick Children Atypical hemolytic uremic syndrome: a new pathological role for complement and coagulation control in platelets TYPE 2009 New Annual (Pending) $ 96 878 Lillicrap, David  Queen's University Gain-of-function mutants affecting the glycoprotein Ib/von Willebrand factor interaction: Potential novel antithrombotic molecules TYPE 2008 New Annual $ 142 860 Linkins, Lori-Ann  McMaster University Evaluation of a diagnostic strategy for patients with suspected heparin-induced thrombocytopenia (HIT) TYPE 2009 Renewal $ 39 907 Liu, Fang  Centre for Addiction and Mental Health Functional and molecular characterization of protein-protein interaction between AMPA receptors and GAPDH (Glyceraldehyde-3-phosphate Dehydrogenase) TYPE 2008 Renewal $ 95 300 Liu, Peter P.  University Health Network Strategies to optimize mobilization, homing and reconstitution therapy in cardiac repair post-infarction TYPE 2009 Renewal $ 80 000 Mak, Alan S.  Queen's University Cortactin and caldesmon in vascular smooth muscle cell migration and invasion TYPE 2006 Renewal $ 100 559 Mak, Susanna  Mount Sinai Hospital Studies of sympathetic nervous system activation in patients with pulmonary arterial hypertension TYPE 2008 New Annual $ 57 596 Mak, Susanna  Mount Sinai Hospital Sex determinants of left ventricular mechanical performance in humans with and without heart failure TYPE 2008 New Annual $ 63 814 Marcel, Yves L.  University of Ottawa Heart Institute Low HDL syndrome and the inflamed monocytes TYPE 2009 Renewal $ 80 000 Mark, Amy E.  University of Ottawa Heart Institute Intervention for dietary behaviour change among individuals at risk for CHD TYPE 2009 Fellowship $ 59 500 Marsden, Philip A.  University of Toronto The human nitric oxide synthase genes: relevance to disease TYPE 2008 Career Investigator $ 43 975 Marsden, Philip A.  University of Toronto Regulated expression of the human nNOS gene TYPE 2006 Renewal $ 115 303 Marsden, Philip A.  University of Toronto Post-transcriptional regulation of endothelial gene expression TYPE 2009 Renewal $ 129 915 Martino, Tami A.  University of Guelph Circadian control of cardiac remodeling TYPE 2008 New Annual (Pending) $ 78 981 Maurice, Donald H.  Queen's University PDEs in blood vessels TYPE 2006 Career Investigator $ 87 950 Maurice, Donald H.  Queen's University Phosphodiesterases in arteries TYPE 2008 Renewal $ 96 592 McBride, Heidi M.  University of Ottawa Heart Institute Mechanism and function of mitochondrial derived vesicles TYPE 2008 Renewal $ 125 415 McCrindle, Brian W.  Hospital for Sick Children Increasing physical activity among children with congenital heart defects TYPE 2009 Renewal $ 208 062 McCulloch, Christopher A.G.  University of Toronto Role of intercellular adhesions in diabetic cardiomyopathy TYPE 2009 New Annual (Pending) $ 95 620 McPherson, Mark A.  Queen's University Physical activity as a determinant of melatonin levels in rotating shift nurses TYPE 2009 Master's Studentship (Pending) $ 18 500 McPherson, Ruth  University of Ottawa Heart Institute Genotype to phenotype: functional analysis of CHD genetic variants TYPE 2009 New Annual (Pending) $ 78 827 Mecredy, Graham C.  Queen's University Built environments as determinants of cardioprotective behaviours in Canadian adolescents TYPE 2009 Master's Studentship (Pending) $ 18 500 Mehta, Sanjay  London Health Sciences Centre Complex regulation of microvascular endothelial cell function in sepsis TYPE 2008 Renewal $ 121 364 Min, Wei-Ping  University of Western Ontario Preventing heart graft rejection by inhibiting innate and adaptive alloimmunity through gene silencing of toll-like receptors TYPE 2009 Renewal $ 79 640 Morshead, Cindi M.  Out of Ontario The development of drug and cell delivery systems for use in cell based therapies to treat stroke TYPE 2008 New Annual $ 40 000 Morshead, Cindi M.  University of Toronto The development of drug and cell delivery systems for use in cell based therapies to treat stroke TYPE 2008 New Annual $ 144 650 Murkin, John M.  London Health Sciences Centre Genetic determinants of neurocognitive dysfunction following cardiopulmonary bypass TYPE 2008 Renewal $ 87 078 Nanthakumar, Kumaraswamy  University Health Network Electrophysiological implications of regenerative therapy TYPE 2009 New Annual (Pending) $ 90 985 Nemer, Mona  University of Ottawa Mechanisms of TBX5 action in the heart TYPE 2008 New Annual $ 118 196 Ng, Dominic S.K.  St. Michael's Hospital Regulation of lipids, insulin action and cell stress in LCAT deficient mice TYPE 2008 New Annual $ 119 932 Ni, Heyu  St. Michael's Hospital Novel mechanisms of platelet aggregation: unveiling new roles of non-classical beta3 integrin ligands in thrombosis and hemostasis TYPE 2008 Renewal $ 115 494 Nurse, Colin A.  McMaster University Functional and anatomical characterization of rat aortic body chemoreceptors TYPE 2009 New Annual (Pending) $ 77 106 O'Brien, Edward R.M.  University of Ottawa Heart Institute Extracellular and intracellular vascular roles of HSP27:  an estrogen receptor beta associated heat shock protein TYPE 2008 Renewal $ 79 936 Opas, Michal J.  University of Toronto The role of calreticulin in cardiac remodelling TYPE 2009 New Annual (Pending) $ 68 905 Park, David S.  University of Ottawa Pathways which regulate neuronal death TYPE 2006 Career Investigator $ 87 950 Park, David S.  University of Ottawa Oxidative stress and ischemic death TYPE 2008 Renewal $ 123 066 Park, David S.  University of Ottawa Mechanism of delayed death in stroke TYPE 2009 Renewal $ 136 414 Parker, John D.  Mount Sinai Hospital Development of a new technique to assess endothelial function: flow mediated constriction TYPE 2008 New Annual $ 133 653 Parker, John D.  University of Toronto Clinical studies concerning nitrate pharmacology and autonomic physiology in congestive heart failure TYPE 2007 Career Investigator (Pending) $ 87 950 Parker, John D.  University of Toronto The Sifton Distinguished Scientist Award TYPE 2008 Sifton Award $ 10 000 Parker, Thomas G.  St. Michael's Hospital EF-hand proteins, S100A1 and A6, in cardiovascular pathophysiology TYPE 2008 New Annual $ 121 241 Parkinson, John  Hospital for Sick Children An interdisciplinary approach to identifying and characterizing polymorphisms in tropoelastin and their role in late onset cardiovascular disease TYPE 2009 Renewal $ 113 392 Peng, Tianqing  London Health Sciences Centre Role of calpain activation in myocardial dysfunction in sepsis TYPE 2008 New Annual $ 106 117 Peng, Tianqing  London Health Sciences Centre Targeting mitochondrial redox signaling to prevent myocardial dysfunction in sepsis TYPE 2009 Renewal $ 110 576 Pickering, J. Geoffrey  University of Western Ontario Role of smooth muscle cells in vascular disease TYPE 2008 Career Investigator $ 43 975 Pilote, Louise  McGill University Genesis praxy: Gender and sex determinants of cardiovascular disease from bench to beyond in premature acute coronary syndrome TYPE 2008 New Annual $ 45 524 Pilote, Louise  Out of Ontario Genesis praxy: Gender and sex determinants of cardiovascular disease from bench to beyond in premature acute coronary syndrome TYPE 2008 New Annual $ 140 831 Prado, Marco A.M.  Robarts Research Institute Decreased cholinergic tone and heart dysfunction TYPE 2009 New Annual $ 126 288 Rac, Valeria E.  St. Michael's Hospital Prehospital Evaluation and Economic Analysis f Different Coronary Syndrome Treatment Strategies - PREDICT TYPE 2009 Fellowship $ 59 500 Rao, Vivek  University Health Network EGFL-7, rapamycin and transplant vasculopathy. TYPE 2009 Renewal $ 61 530 Redington, Andrew N.  Hospital for Sick Children The effect of remote ischemic preconditioning on clinical and genomic responses to open heart surgery in children TYPE 2009 New Annual (Pending) $ 167 565 Reid, Robert D.  University of Ottawa Heart Institute Efficacy and cost-effectiveness of cost-free pharmacotherapy for smoking cessation for high-risk smokers with cerebrovascular disease TYPE 2009 New Annual (Pending) $ 223 389 Retnakaran, Ravi R.  Mount Sinai Hospital The early natural history of cardiovascular disease at 4-years postpartum in young women with varying degrees of glucose intolerance in pregnancy TYPE 2009 New Annual (Pending) $ 60 294 Rocca, Antonio  University of Toronto Mediation of Flow-Induced Arterial Remodelling TYPE 2008 Clinician Scientist $ 64 000 Rocheleau, Jonathan V.  University Health Network Interaction between vascular endothelial cells and pancreatic beta cells: understanding the role of fibroblast growth factor(FGF) TYPE 2009 New Annual (Pending) $ 87 084 Rodger, Marc A.  Ottawa Hospital Research Institute Thrombophilia and placenta mediated pregnancy complications TYPE 2007 Career Investigator (Pending) $ 87 950 Rodger, Marc A.  Ottawa Hospital Research Institute Recurrent venous thromboembolism risk stratification evaluation (REVERSE) : long term follow-up to define if lifelong anticoagulation is required in high risk patients with a first unprovoked venous thromboembolism TYPE 2009 New Annual $ 110 269 Rose, David R.  University Health Network The molecular basis for starch digestion in the intestine: Human maltase-glucoamylase and sucrase-isomaltase TYPE 2008 New Annual $ 82 604 Roy, Eric A.  University of Waterloo Neuropsychological profiles and neuroanatomic correlates of limb apraxia TYPE 2007 Renewal (Pending) $ 69 864 Ruel, Marc Andre  University of Ottawa Heart Institute Evaluation of biopolymer delivered EPCs for cardiac repair in a swine model of hibernating myocardium TYPE 2009 Renewal $ 795 36 Rui, Tao  London Health Sciences Centre Role of HMGB1 in ischemia/reperfusion-induced myocardial injury TYPE 2008 New Annual $ 97 895 Salbach, Nancy M.  University of Toronto Building physiotherapists' capacity to implement evidence-based stroke rehabilitation TYPE 2008 Clinician Scientist $ 64 000 Saposnik, Gustavo  St. Michael's Hospital Premature Stroke Associated with Recency of Immigration to Ontario (PRESARIO) TYPE 2008 Clinician Scientist $ 64 000 Schlichter, Lyanne C.  University Health Network Pathophysiology and inflammation after intracerebral hemorrhage TYPE 2008 Renewal $ 110 497 Schlichter, Lyanne C.  University Health Network Modulating modes of microglial activation to reduce secondary stroke injury TYPE 2009 Renewal $ 116 223 Shah, Baiju R.  Sunnybrook Health Sciences Centre Diabetes care and outcomes for people with Chinese and South Asian origins TYPE 2008 New Annual $ 30 657 Shaughnessy, Stephen G.  McMaster University Mechanism(s) of low molecular weight heparin-induced bone loss TYPE 2009 New Annual (Pending) $ 80 000 Sheffield, William P.  McMaster University Exploring engineered serpins as potential antithrombotic agents TYPE 2008 Renewal $ 98 750 Sheffield, William P.  McMaster University Transforming hirudin into an activatable, clot-localized thrombin inhibitor TYPE 2009 Renewal $ 98 232 Shoemaker, J. Kevin  University of Western Ontario Plasticity of cortical-cardiovascular interactions in vascular disease TYPE 2008 Renewal $ 79 756 Simmons, Craig A.  University of Toronto The role of C-type natriuretic peptide in cardiac valve fibrosis TYPE 2009 New Annual (Pending) $ 89 473 Slack, Ruth  Ottawa Hospital Research Institute Regulation of Mcl1 to treat stroke TYPE 2006 Renewal $ 104 254 So, Derek Y.F.  University of Ottawa Heart Institute Obstructive sleep apnea as a risk factor for clopidogrel unresponsiveness in patients undergoing percutaneous coronary intervention: prevalence, mechanisms and possible influence on clinical outcomes TYPE 2009 New Annual $ 79 100 Sofrenovic, Tanja  University of Ottawa Enhanced matrix for recruitment of circulating progenitor cells to the heart TYPE 2009 Master's Studentship (Pending) $ 18 500 Sorisky, Alexander  Ottawa Hospital Research Institute MAPping adipose tissue malfunction in obesity: macrophages, adipose cells, and PDGF TYPE 2009 New Annual $ 138 633 Spafford, J. David  University of Waterloo Structure-function analyses of drug interactions with L-type calcium channels TYPE 2008 New Annual $ 78 882 Sparks, Daniel L.  University of Ottawa Heart Institute The role of HDL in triglyceride metabolism TYPE 2008 Renewal $ 80 000 Spencer, Frederick A.  McMaster University Clinical epidemiology and management of cardiovascular and venous thromboembolic disease TYPE 2007 Career Investigator (Pending) $ 87 950 Spencer, Frederick A.  McMaster University Fortinos Distinguished Scientist Award TYPE 2007 Fortinos Award $ 10 000 St. Lawrence, Keith S.  London Health Sciences Centre Oxygen consumption is an early predictor of brain damage following hypoxia-ischemia TYPE 2009 New Annual (Pending) $ 88 730 Stagljar, Igor  University of Toronto Functional analysis of the interactome of the human B-adrenergic receptors TYPE 2009 New Annual (Pending) $ 92 563 Steinman, David A.  University of Toronto Hemodynamic factors in vascular disease: from bench to bedside. TYPE 2009 Career Investigator $ 87 950 Steinman, David A.  University of Toronto Flow in the common carotid artery is not fully-developed: implications for studies of atherosclerosis TYPE 2009 New Annual (Pending) $ 47 023 Sugita, Shuzo  University Health Network The roles of CAPS1 in catecholamine secretion TYPE 2009 Renewal $ 78 387 Suskin, Neville G.  Lawson Health Research Institute Comprehensive cardiac rehabilitation programming for patients following transient ischemic attack (extension) TYPE 2009 Renewal $ 157 404 Suuronen, Erik J.  University of Ottawa Heart Institute Recruitment of endogenous circulating progenitor cells for cardiac regeneration using enhanced tissue-engineered biomatrices TYPE 2009 Renewal $ 130 078 Syme, Catriona A.  Hospital for Sick Children Determinants of Cardiovascular and Metabolic Risk in Overweight Children and Adolescents TYPE 2009 Fellowship $ 59 500 Syrett, Andrew J.  University of Ottawa Bioactive glycerophospholipids and their role in modulating neuronal vulnerability following ischemia TYPE 2009 Master's Studentship (Pending) $ 18 500 Tang, Damu  McMaster University Characterization of a novel insig binding protein (INsigBP1) TYPE 2008 New Annual $ 81 500 Tesson, Frederique  University of Ottawa Cell nucleus and dilated cardiomyopathy. TYPE 2009 New Annual (Pending) $ 96 389 Tobe, Sheldon W.  Sunnybrook Health Sciences Centre Harmony study (Hypertension analysis of stress reduction using mindfulness meditation and yoga) TYPE 2008 New Annual $ 75 197 Touyz, Rhian M.  Ottawa Hospital Research Institute TRPM7 signaling through lipid rafts in vascular smooth muscle cells - implications in hypertension TYPE 2008 Renewal $ 11 7395 Tsushima, Robert G.  York University SNARE protein regulation of cardiac ion channels and ANF secretion. TYPE 2009 Career Investigator $ 87 950 Tsushima, Robert G.  York University Cell signalling in myocardial ischemia preconditioning TYPE 2008 New Annual $ 79 700 Tsushima, Robert G.  York University SNARE protein regulation of cardiac ion channels and ANF secretion TYPE 2009 Renewal $ 101 500 Tulloch, Heather E.  University of Ottawa Heart Institute Interventions to reduce cardiovascular disease: ""real world"" effectiveness of combined pharmacotherapy and behavioral counselling for smoking cessation. TYPE 2009 New Annual (Pending) $ 253 366 Van Huysse, James W.  University of Ottawa Heart Institute Roles of the brain Na, K-ATPase alpha isoforms in the regulation of blood pressure TYPE 2008 New Annual $ 76 018 Veerman, Kaley J.  McMaster University Investigating the role of the vasa vasorum in the development of diabetic atherosclerosis TYPE 2009 Master's Studentship (Pending) $ 18 500 Verma, Subodh  St. Michael's Hospital Elucidating the in vivo role of adiponectin in inflammation: a biochemical and pharmacological approach TYPE 2009 New Annual (Pending) $ 65 979 Verma, Subodh  St. Michael's Hospital Neuregulin-1 as a novel treatment for endothelial dysfunction and atherosclerosis TYPE 2009 New Annual (Pending) $ 80 000 von Harsdorf, Rudiger  University Health Network Evaluation of p21CIP1/WAF1 protein transduction as a novel therapeutic approach in heart failure TYPE 2008 New Annual $ 80 000 Wade, Terrance J.  Brock University Social Determinants of Child Hypertension TYPE 2007 Social Determinants $ 100 010 Walley, Keith R.  Out of Ontario Genetic determinants of neurocognitive dysfunction following cardiopulmonary bypass TYPE 2008 Renewal $ 80 000 Wang, Hao  University of Western Ontario Soluble CD83 based therapy in cardiac allograft tolerance TYPE 2008 Renewal $ 79 967 Ween, Jon Erik  Baycrest Refinement of a point-of-care, electronic testing tool for the longitudinal stroke assessments TYPE 2009 New Annual (Pending) $ 80 000 Weitz, Jeffrey I.  McMaster University Impact of gamma' fibrinogen on clot formation and clot lysis at sites of plaque rupture TYPE 2008 Renewal $ 118 563 Wells, James W.  University of Toronto Nature of the signalling complex between cardiac muscarinic receptors and G proteins TYPE 2008 Renewal $ 85 052 Wells, Philip S.  Ottawa Hospital Research Institute Development and validation of clinical prediction rules for bleeding for patients on anticoagulant therapy for venous thromboembolism TYPE 2008 New Annual $ 191 647 Wen, Xiao-Yan  St. Michael's Hospital Roles of novel lpdl and lpdlr phospholipases in platelet activation and thrombosis TYPE 2009 Renewal $ 118 125 White, James A.  London Health Sciences Centre Multi-modality imaging assessment for pacing interventions in heart failure (MAPIT-HF) TYPE 2008 New Annual $ 116 610 White, James A.  University of Western Ontario Myocardial Scar Imaging in Heart Failure: Prediction of Risk and Therapeutic Response TYPE 2009 Clinician Scientist $ 64 000 Whitman, Stewart C.  University of Ottawa Heart Institute The role of the innate immune system in atherosclerosis: Further defining the role of NKT cells, interferon-gamma and IL-4 in the disease process TYPE 2008 Renewal $ 108 184 Yang, Burton B.  Sunnybrook Health Sciences Centre Roles of versican in mediating leukocyte and endothelial cell activities TYPE 2006 Career Investigator $ 87 950 Yang, Burton B.  Sunnybrook Health Sciences Centre Roles of miR-17-5p in endothelial wound healing and angiogenesis TYPE 2008 New Annual $ 82 060 Yang, Burton B.  Sunnybrook Health Sciences Centre MicroRNA miR-378 regulates self renewal and angiogenesis TYPE 2009 New Annual (Pending) $ 103 720 Yeung, Rae S.M.  Hospital for Sick Children Towards a better understanding of kawasaki disease TYPE 2008 Renewal $ 79 870 Zandstra, Peter W.  University of Toronto Interrogating the cardiomyogenic hierarchy to optimize cardiovascular cell therapy TYPE 2009 Renewal $ 143 700 Zhang, Shetuan  Queen's University Control of cell surface channel density by potassium as a novel mechanism for hERG regulation. TYPE 2009 Renewal $ 142 295 Zhang, Wandong  University of Ottawa Modulation of MMP9 expression induced by cerebral ischemia and reperfusion to reduce blood-brain barrier permeability and brain damage in ischemic stroke TYPE 2008 New Annual $ 56 200 Zhang, Zhu-Xu  London Health Sciences Centre Therapeutic potential and mechanism of double-negative regulatory T (DN-Treg) cells mediated tolerance in heart transplantation TYPE 2009 Renewal $ 92 080

Last Updated ( Monday, 15 March 2010 )