Heart and Stroke Foundation of Ontario

Results of September 2008 Grant-in-Aid (GIA) and Career Investigator Competitions

The Heart and Stroke Foundation of Ontario is pleased to announce the results of the September 2008 Grant-in-Aid and Career Investigator competitions.

The GIA competition
This competition surpassed HSFO records for the largest number of applications received (237) and the highest overall dollar request (first year - $32.6 million; all years - $114.5 million). This represented a 20% increase in requested dollars over the September, 2007 competition. HSFO was able to offer funding to 104 investigators – a first-year investment of $10.8 million. The five-year investment is $35.6 million, a 6% increase over 2007.

The competition results posted below are to be considered preliminary only. An official letter will be sent to all applicants the week of March 23, 2009, along with the budget / funding details and rankings.

The list provides the name of the principal investigator, institution, title, type of grant, first-year operating budget, term of the grant, and whether any condition has been placed on approval of the grant. For those awards identified as "pending", funding is encumbered until additional information is provided. This will be addressed in the letters to applicants noted above. This list is for information only.

Career Investigator awards do not have first year amounts, however the standard stipend applies.

The Foundation requests that applicants do not write or telephone with any enquiries before receiving the award letters.

Adamson, S. Lee (Mount Sinai Hospital)

Role of placental VEGF-A, FLT1 and sFLT1 in placental vascularity, fetal growth, and maternal function in mice

TYPE 2 Year
New Annual
(Pending)
$ 80,000

Adeli, Khosrow (Hospital for Sick Children)

Molecular mechanisms of apolipoprotein B degradation

TYPE 5 Year
Renewal
$ 132,176

Andrew, Robert David (Queen's University)

Mechanisms that drive acute neuronal swelling and dysfunction in stroke

TYPE 3 Year
Renewal
(Pending)
$ 84,841

Backx, Peter H. (University of Toronto)

Studies into molecular mechanisms of cardiovascular disease

TYPE 2.5 Year
Career Investigator
 

Beattie, William S. (University Health Network)

The ENIGMA-II trial. Nitrous oxide anaesthesia and cardiac morbidity after major surgery: a randomized controlled trial

TYPE 2 Year
New Annual
(Pending)
$ 80,000

Bendeck, Michelle P. (University of Toronto)

Discoidin domain receptors in atherosclerosis

TYPE 5 Year
Renewal
$ 152,320

Bolz, Steffen-Sebastian (University of Toronto)

Mechanisms that regulate the pressure-dependent activation of sphingosine kinase 1 in resistance artery smooth muscle cells

TYPE 3 Year
Renewal
$ 80,916

Brooks, Dina (University of Toronto)

Effects of cardiac rehabilitation for individuals after transient ischemic attack

TYPE 2 Year
New Annual
$ 80,000

Cameron, Jill I. (University of Toronto)

Optimizing stroke family caregiver support across the care continuum by improving the timing of intervention delivery

TYPE 3 Year
New Annual
(Pending)
$ 148,082

Carrier, Marc (Ottawa Health Research Institute)

Screening for previously undiagnosed malignancy in patients with unprovoked venous thromboembolism: a randomized controlled trial using a comprehensive computed tomography of the abdomen/pelvis

TYPE 2 Year
New Annual
(Pending)
$ 80,000

Chan, Christopher T.M. (University Health Network)

Towards an improved understanding of vascular progenitor cell biology in uremia

TYPE 2 Year
New Annual
(Pending)
$ 64,246

Cherney, David Z.I. (University Health Network)

Hemodynamic and molecular mechanisms of hyperfiltration in type I diabetes mellitus

TYPE 3 Year
New Annual
(Pending)
$ 78,795

Chretien, Michel (Ottawa Health Research Institute)

PCSK9 in cholesterol homeostasis: the key role of phosphorylation and hormonal status

TYPE 2 Year
New Annual
(Pending)
$ 77,000

Crowther, Mark A. (McMaster University)

Reducing cardiovascular disease by improving our use of antithrombotic agents.

TYPE 5 Year
Career Investigator
 

Crowther, Mark A. (McMaster University)

Does low dose oral vitamin K improve the quality of warfarin anticoagulation

TYPE 3 Year
New Annual
(Pending)
$ 86,575

Cybulsky, Myron I. (University Health Network)

Endothelial cell NF-kappaB homeostasis and function in atherosclerosis

TYPE 4 Year
New Annual
(Pending)
$ 121,146

Daneman, Denis (Hospital for Sick Children)

Adolescent type 1 Diabetes cardio-renal Intervention trial (AdDIT)

TYPE 4 Year
New Annual
(Pending)
$ 91,020

Demers, Catherine (McMaster University)

The impact of mild cognitive deficits at hospital discharge on self-care in older heart failure patients

TYPE 3 Year
New Annual
$ 97,569

Dorian, Paul (St. Michael's Hospital)

Studies of the effect of fish oil derived omega-3 Polyunsaturated fatty acids ( EPA and DHA), and omega-6 fatty acids on experimental atrial fibrillation, and mechanisms of their antiarrhythmic effects

TYPE 3 Year
New Annual
(Pending)
$ 126,562

Egan, Mary (University of Ottawa)

Engaging in values activities post stroke

TYPE 2 Year
New Annual
$ 47,287

Eikelboom, John W.A. (McMaster University)

Thrombotic mechanisms as predictors of Vascular events In non-cardiac Surgery patIents cohOrt evaluatioN (ThromboVISION)

TYPE 3 Year
New Annual
(Pending)
$ 128,934

Feldman, Ross D. (University of Western Ontario)

Determinants of adenylyl cyclase-mediated vascular responses.

TYPE 4 Year
Renewal
(Pending)
$ 146,322

Feng, Qingping (University of Western Ontario)

Heart development in diabetes: role of nitric oxide

TYPE 3 Year
New Annual
(Pending)
$ 133,267

Feng, Qingping (University of Western Ontario)

Rac1 signaling in myocardial TNF-alpha expression in sepsis

TYPE 2 Year
New Annual
(Pending)
$ 80,000

Funk, Colin D. (Queen's University)

Biochemistry and biology of cyclooxygenases

TYPE 5 Year
New Annual
(Pending)
$ 134,381

Funk, Colin D. (Queen's University)

COX-2 pathway and cardiovascular disease

TYPE 5 Year
Renewal
(Pending)
$ 115,882

Grace, Sherry L. (University Health Network)

An RCT of women's adherence to women-only, home-based and traditional cardiac rehabilitation (Cardiac Rehabilitation for Her heart Event Recovery [CR4HER])

TYPE 3 Year
New Annual
(Pending)
$ 108,179

Gross, Peter L. (McMaster University)

Defining how atorvastatin inhibits platelets

TYPE 2 Year
Renewal
$ 80,000

Gula, Lorne J. (University of Western Ontario)

Monitoring of Ventricular Rhythm & Exercise - ICD study (MOVE-IT).

TYPE 3 Year
New Annual
(Pending)
$ 71,574

Hayward, Catherine P. (McMaster University)

Molecular cause of profibrinolytic human platelets and leukocytes.

TYPE 2 Year
Renewal
$ 80,000

Hayward, Catherine P. (McMaster University)

Functions of multimerin 1 as a platelet adhesive protein.

TYPE 2 Year
Renewal
$ 80,000

Heckman, George A.W. (McMaster University)

Adapting the Canadian cardiovascular society recommendations on heart failure: a consensus-based approach with stakeholder input

TYPE 2 Year
New Annual
(Pending)
$ 79,571

Hegele, Robert A. (University of Western Ontario)

Genomics of hypertriglyceridemia

TYPE 5 Year
Renewal
$ 168,410

Heximer, Scott P. (University of Toronto)

Defining the molecular pathways through which RGS4 regulates parasympathetic signaling and heart rate control in sinoatrial node myocytes

TYPE 5 Year
Renewal
(Pending)
$ 147,955

Holden, Rachel M. (Queen's University)

Mechanisms of vascular calcification (VC) in a model of chronic kidney disease (CKD)

TYPE 3 Year
New Annual
(Pending)
$ 85,855

Hou, Sheng T. (University of Ottawa)

Investigation of SEMA3A's role in angiogenesis and vascular permeability during stroke recovery

TYPE 3 Year
Renewal
$ 70,916

Hough, Margaret R. (Sunnybrook Health Sciences Centre)

Cardiac repair and regeneration

TYPE 2 Year
Renewal
$ 79,500

Husain, Mansoor (University of Toronto)

Molecular studies of cardiac and vascular disease.

TYPE 5 Year
Career Investigator
 

Husain, Mansoor (University Health Network)

Plasma membrane Ca2+ ATPase 4 isoforms: regulation and role in cardiac and smooth muscle

TYPE 3 Year
New Annual
(Pending)
$ 115,230

Husain, Mansoor (University Health Network)

c-Myb-dependent proliferation & differentiation of vascular smooth muscle cells (VSMC)

TYPE 3 Year
New Annual
(Pending)
$ 110,250

Husain, Mansoor (University Health Network)

The role of glucagon-like peptide-1 in cardiac health and disease

TYPE 5 Year
Renewal
(Pending)
$ 140,000

Jin, Tianru (University Health Network)

A novel mechanism in controlling the expression of ChREBP and lipogenesis

TYPE 2 Year
New Annual
$ 66,759

Jones, Nina (University of Guelph)

Cell migration pathways in mammalian cardiovascular development

TYPE 5 Year
New Annual
(Pending)
$ 97,685

Karkouti, Keyvan (University Health Network)

Advance targeted transfusion in anemic cardiac surgical patients for kidney protection: a proof of concept pilot study.

TYPE 2 Year
New Annual
(Pending)
$ 62,101

Keeley, Fred W. (Hospital for Sick Children)

Recombinantly expressed elastin-like polypeptides as a novel tool for investigations of the structure, assembly, and the properties of elastin-like materials

TYPE 4 Year
Renewal
$ 129,236

Keith, Mary E. (St. Michael's Hospital)

A randomized controlled trial of the effect of thiamin supplementation on heart function in ambulatory patients with heart failure

TYPE 3 Year
New Annual
(Pending)
$ 84,637

Khokha, Rama (University Health Network)

Molecular dissection of the distinct functions of TIMP-3 and TIMP-4 in heart disease

TYPE 5 Year
Renewal
(Pending)
$ 114,381

Kislinger, Thomas (University Health Network)

Identification and characterization of cell-surface associated protein in the heart : applications of a novel proteomic strategy

TYPE 5 Year
New Annual
$ 126,785

Krahn, Andrew D. (University of Western Ontario)

Inherited causes of sudden death: phenotype genotype correlation

TYPE 4 Year
Renewal
$ 168,777

Kuebler, Prof. Wolfgang (St. Michael's Hospital)

New concept of hypoxic pulmonary vasoconstriction: conducted response via connexin 40.

TYPE 3 Year
New Annual
(Pending)
$ 88,605

Lagace, Thomas A. (University of Ottawa Heart Institute)

Regulation of the PCSK9 binding interaction with LDL receptor

TYPE 3 Year
New Annual
(Pending)
$ 76,819

Lee, Ting-Yim (Lawson Health Research Institute)

Prediction of hemorrhagic transformation of ischemic stroke with CT perfusion derived blood-brain-barrier permeability surface area product

TYPE 5 Year
New Annual
(Pending)
$ 90,674

Leenen, Frans H.H. (University of Ottawa Heart Institute)

Brain mechanisms determining sympathetic hyperactivity and cardiac dysfunction in rats post MI

TYPE 5 Year
New Annual
(Pending)
$ 130,922

Leong-Poi, Howard M. (St. Michael's Hospital)

Role of statins in progenitor cell therapy for chronic ischemia

TYPE 2 Year
New Annual
(Pending)
$ 73,400

Li, Ren-Ke (University Health Network)

Modifying cardiac repair using molecular and cellular interventions

TYPE 2 Year
Renewal
$ 80,000

Licht, Christoph P.B. (Hospital for Sick Children)

Atypical hemolytic uremic syndrome: a new pathological role for complement and coagulation control in platelets

TYPE 3 Year
New Annual
$ 94,470

Linkins, Lori-Ann (McMaster University)

Evaluation of a diagnostic strategy for patients with suspected heparin-induced thrombocytopenia (HIT)

TYPE 2 Year
Renewal
(Pending)
$ 79,809

Liu, Peter P. (University Health Network)

Strategies to optimize mobilization, homing and reconstitution therapy in cardiac repair post-infarction

TYPE 2 Year
Renewal
(Pending)
$ 80,000

MacDonald, John F. (University of Western Ontario)

The characterization of non-selective cation channels contributing to delayed cell death following stroke

TYPE 5 Year
New Annual
(Pending)
$ 150,343

Marcel, Yves L. (University of Ottawa Heart Institute)

Low HDL syndrome and the inflamed monocytes

TYPE 2 Year
Renewal
(Pending)
$ 80,000

Marsden, Philip A. (University of Toronto)

Post-transcriptional regulation of endothelial gene expression

TYPE 5 Year
Renewal
(Pending)
$ 12,9915

Martino, Rosemary (University of Toronto)

Psychometric testing of a new scale measuring medical outcomes of dysphagia (MOD) in adult patients with swallowing disorders secondary to stroke

TYPE 3 Year
New Annual
(Pending)
$ 165,427

McCrindle, Brian W. (Hospital for Sick Children)

Increasing physical activity among children with congenital heart defects

TYPE 3 Year
Renewal
$ 176,045

McCulloch, Christopher A. (University of Toronto)

Role of intercellular adhesions in diabetic cardiomyopathy

TYPE 3 Year
New Annual
$ 94,000

McPherson, Ruth (University of Ottawa Heart Institute)

Genotype to phenotype: functional analysis of CHD genetic variants

TYPE 2 Year
New Annual
(Pending)
$ 79,080

Min, Wei-Ping (University of Western Ontario)

Preventing heart graft rejection by inhibiting innate and adaptive alloimmunity through gene silencing of toll-like receptors

TYPE 2 Year
Renewal
$ 77,380

Nanthakumar, Kumaraswamy (University Health Network)

Electrophysiological implications of regenerative therapy

TYPE 3 Year
New Annual
(Pending)
$ 89,365

Nurse, Colin A. (McMaster University)

Functional and anatomical characterization of rat aortic body chemoreceptors

TYPE 2 Year
New Annual
(Pending)
$ 75,594

Opas, Michal J. (University of Toronto)

The role of calreticulin in cardiac remodelling

TYPE 2 Year
New Annual
(Pending)
$ 68,338

Park, David S. (University of Ottawa)

Mechanism of delayed death in stroke

TYPE 3 Year
Renewal
$ 135,639

Parkinson, John (Hospital for Sick Children)

An interdisciplinary approach to identifying and characterizing polymorphisms in tropoelastin and their role in late onset cardiovascular disease

TYPE 3 Year
Renewal
$ 109,947

Peng, Tianqing (London Health Sciences Centre)

Targeting mitochondrial redox signaling to prevent myocardial dysfunction in sepsis

TYPE 5 Year
Renewal
(Pending)
$ 112,934

Prado, Marco A.M. (University of Western Ontario)

Decreased cholinergic tone and heart dysfunction

TYPE 5 Year
New Annual
(Pending)
$ 126,288

Rao, Vivek (University Health Network)

EGFL-7, rapamycin and transplant vasculopathy.

TYPE 2 Year
Renewal
$ 60,500

Redington, Andrew N. (Hospital for Sick Children)

The effect of remote ischemic preconditioning on clinical and genomic responses to open heart surgery in children

TYPE 3 Year
New Annual
(Pending)
$ 148,534

Reid, Robert D. (University of Ottawa Heart Institute)

Efficacy and cost-effectiveness of cost-free pharmacotherapy for smoking cessation for high-risk smokers with cerebrovascular disease

TYPE 3 Year
New Annual
(Pending)
$ 258,098

Retnakaran, Ravi R. (Mount Sinai Hospital)

The early natural history of cardiovascular disease at 4-years postpartum in young women with varying degrees of glucose intolerance in pregnancy

TYPE 3 Year
New Annual
$ 59,836

Rocheleau, Jonathan V. (University Health Network)

Interaction between vascular endothelial cells and pancreatic beta cells: understanding the role of fibroblast growth factor(FGF)

TYPE 3 Year
New Annual
(Pending)
$ 85,450

Rodger, Marc A. (Ottawa Health Research Institute)

Recurrent venous thromboembolism risk stratification evaluation (REVERSE) : long term follow-up to define if lifelong anticoagulation is required in high risk patients with a first unprovoked venous thromboembolism

TYPE 4 Year
New Annual
(Pending)
$ 111,945

Ruel, Marc Andre (University of Ottawa Heart Institute)

Evaluation of biopolymer delivered EPCs for cardiac repair in a swine model of hibernating myocardium

TYPE 2 Year
Renewal
(Pending)
$ 79,536

Schlichter, Lyanne C. (University Health Network)

Modulating modes of microglial activation to reduce secondary stroke injury

TYPE 5 Year
Renewal
(Pending)
$ 128,526

Shaughnessy, Stephen G. (McMaster University)

Mechanism(s) of low molecular weight heparin-induced bone loss

TYPE 2 Year
New Annual
(Pending)
$ 80,000

Sheffield, William P. (McMaster University)

Transforming hirudin into an activatable, clot-localized thrombin inhibitor

TYPE 3 Year
Renewal
(Pending)
$ 103,190

Simmons, Craig A. (University of Toronto)

The role of C-type natriuretic peptide in cardiac valve fibrosis

TYPE 3 Year
New Annual
$ 88,000

So, Derek Y.F. (University of Ottawa Heart Institute)

Obstructive sleep apnea as a risk factor for clopidogrel unresponsiveness in patients undergoing percutaneous coronary intervention: prevalence, mechanisms and possible influence on clinical outcomes

TYPE 2 Year
New Annual
(Pending)
$ 79,100

Sorisky, Alexander (Ottawa Health Research Institute)

MAPping adipose tissue malfunction in obesity: macrophages, adipose cells, and PDGF

TYPE 5 Year
New Annual
(Pending)
$ 135,537

St. Lawrence, Keith S. (London Health Sciences Centre)

Oxygen consumption is an early predictor of brain damage following hypoxia-ischemia

TYPE 3 Year
New Annual
(Pending)
$ 88,730

Stagljar, Igor (University of Toronto)

Functional analysis of the interactome of the human B-adrenergic receptors

TYPE 3 Year
New Annual
$ 94,090

Stefanovic, Bojana (Sunnybrook Health Sciences Centre)

Biophysics of functional MRI

TYPE 3 Year
New Annual
(Pending)
$ 65,885

Steinman, David A. (University of Toronto)

Hemodynamic factors in vascular disease: from bench to bedside.

TYPE 5 Year
Career Investigator
 

Steinman, David A. (University of Toronto)

Flow in the common carotid artery is not fully-developed: implications for studies of atherosclerosis

TYPE 2 Year
New Annual
(Pending)
$ 47,023

Sugita, Shuzo (University Health Network)

The roles of CAPS1 in catecholamine secretion

TYPE 2 Year
Renewal
(Pending)
$ 76,850

Suskin, Neville G. (Lawson Health Research Institute)

Comprehensive cardiac rehabilitation programming for patients following transient ischemic attack(extension)

TYPE 3 Year
Renewal
$ 156,884

Suuronen, Erik J. (University of Ottawa Heart Institute)

Recruitment of endogenous circulating progenitor cells for cardiac regeneration using enhanced tissue-engineered biomatrices

TYPE 3 Year
Renewal
(Pending)
$ 125,232

Tesson, Frederique (University of Ottawa Heart Institute)

Cell nucleus and dilated cardiomyopathy.

TYPE 3 Year
New Annual
(Pending)
$ 94,310

Tsushima, Robert G. (York University)

SNARE protein regulation of cardiac ion channels and ANF secretion.

TYPE 5 Year
Career Investigator
 

Tsushima, Robert G. (York University)

SNARE protein regulation of cardiac ion channels and ANF secretion

TYPE 4 Year
Renewal
(Pending)
$ 100,000

Tulloch, Heather E. (University of Ottawa Heart Institute)

Interventions to reduce cardiovascular disease: ""real world"" effectiveness of combined pharmacotherapy and behavioral counselling for smoking cessation.

TYPE 4 Year
New Annual
(Pending)
$ 258,244

Verma, Subodh (St. Michael's Hospital)

Elucidating the in vivo role of adiponectin in inflammation: a biochemical and pharmacological approach

TYPE 3 Year
New Annual
(Pending)
$ 64,685

Verma, Subodh (St. Michael's Hospital)

Role of the tumor suppressor Gene BRCA1 in adverse cardiac remodeling

TYPE 2 Year
New Annual
(Pending)
$ 80,000

Verma, Subodh (St. Michael's Hospital)

Neuregulin-1 as a novel treatment for endothelial dysfunction and atherosclerosis

TYPE 2 Year
New Annual
$ 80,000

Ween, Jon E. (Baycrest)

Refinement of a point-of-care, electronic testing tool for the longitudinal stroke assessments

TYPE 2 Year
New Annual
$ 80,000

Wen, Xiao-Yan (University Health Network)

Roles of novel lpdl and lpdlr phospholipases in platelet activation and thrombosis

TYPE 3 Year
Renewal
(Pending)
$ 113,126

Werstuck, Geoffrey H. (McMaster University)

Mechanisms by which diabetes mellitus promote accelerated atherosclerosis

TYPE 2 Year
New Annual
(Pending)
$ 79,600

Yang, Burton B. (Sunnybrook Health Sciences Centre)

MicroRNA miR-378 regulates self renewal and angiogenesis

TYPE 3 Year
New Annual
(Pending)
$ 103,720

Yang, Guangdong (Lakehead University)

Regulation of cystathionine gamma-lyase expression in vascular smooth muscle cells

TYPE 2 Year
New Annual
(Pending)
$ 73,700

Zandstra, Peter W. (University of Toronto)

Interrogating the cardiomyogenic hierarchy to optimize cardiovascular cell therapy

TYPE 5 Year
Renewal
$ 143,700

Zhang, Shetuan (Queen's University)

Control of cell surface channel density by potassium as a novel mechanism for hERG regulation.

TYPE 5 Year
Renewal
(Pending)
$ 140,172

Zhang, Zhu-Xu (Lawson Health Research Institute)

Therapeutic potential and mechanism of double-negative regulatory T (DN-Treg) cells mediated tolerance in heart transplantation

TYPE 3 Year
Renewal
(Pending)
$ 100,980
Last Updated ( Friday, 01 May 2009 )