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|
Adamson, S. Lee (Mount Sinai Hospital) Role of placental VEGF-A, FLT1 and sFLT1 in placental vascularity, fetal growth, and maternal function in mice |
TYPE | 2 Year |
|
New Annual (Pending) |
$ 80,000 | |
|
Adeli, Khosrow (Hospital for Sick Children) Molecular mechanisms of apolipoprotein B degradation |
TYPE | 5 Year |
|
Renewal |
$ 132,176 | |
|
Andrew, Robert David (Queen's University) Mechanisms that drive acute neuronal swelling and dysfunction in stroke |
TYPE | 3 Year |
|
Renewal (Pending) |
$ 84,841 | |
|
Backx, Peter H. (University of Toronto) Studies into molecular mechanisms of cardiovascular disease |
TYPE | 2.5 Year |
|
Career Investigator |
||
|
Beattie, William S. (University Health Network) The ENIGMA-II trial. Nitrous oxide anaesthesia and cardiac morbidity after major surgery: a randomized controlled trial |
TYPE | 2 Year |
|
New Annual (Pending) |
$ 80,000 | |
|
Bendeck, Michelle P. (University of Toronto) Discoidin domain receptors in atherosclerosis |
TYPE | 5 Year |
|
Renewal |
$ 152,320 | |
|
Bolz, Steffen-Sebastian (University of Toronto) Mechanisms that regulate the pressure-dependent activation of sphingosine kinase 1 in resistance artery smooth muscle cells |
TYPE | 3 Year |
|
Renewal |
$ 80,916 | |
|
Brooks, Dina (University of Toronto) Effects of cardiac rehabilitation for individuals after transient ischemic attack |
TYPE | 2 Year |
|
New Annual |
$ 80,000 | |
|
Cameron, Jill I. (University of Toronto) Optimizing stroke family caregiver support across the care continuum by improving the timing of intervention delivery |
TYPE | 3 Year |
|
New Annual (Pending) |
$ 148,082 | |
|
Carrier, Marc (Ottawa Health Research Institute) Screening for previously undiagnosed malignancy in patients with unprovoked venous thromboembolism: a randomized controlled trial using a comprehensive computed tomography of the abdomen/pelvis |
TYPE | 2 Year |
|
New Annual (Pending) |
$ 80,000 | |
|
Chan, Christopher T.M. (University Health Network) Towards an improved understanding of vascular progenitor cell biology in uremia |
TYPE | 2 Year |
|
New Annual (Pending) |
$ 64,246 | |
|
Cherney, David Z.I. (University Health Network) Hemodynamic and molecular mechanisms of hyperfiltration in type I diabetes mellitus |
TYPE | 3 Year |
|
New Annual (Pending) |
$ 78,795 | |
|
Chretien, Michel (Ottawa Health Research Institute) PCSK9 in cholesterol homeostasis: the key role of phosphorylation and hormonal status |
TYPE | 2 Year |
|
New Annual (Pending) |
$ 77,000 | |
|
Crowther, Mark A. (McMaster University) Reducing cardiovascular disease by improving our use of antithrombotic agents. |
TYPE | 5 Year |
|
Career Investigator |
||
|
Crowther, Mark A. (McMaster University) Does low dose oral vitamin K improve the quality of warfarin anticoagulation |
TYPE | 3 Year |
|
New Annual (Pending) |
$ 86,575 | |
|
Cybulsky, Myron I. (University Health Network) Endothelial cell NF-kappaB homeostasis and function in atherosclerosis |
TYPE | 4 Year |
|
New Annual (Pending) |
$ 121,146 | |
|
Daneman, Denis (Hospital for Sick Children) Adolescent type 1 Diabetes cardio-renal Intervention trial (AdDIT) |
TYPE | 4 Year |
|
New Annual (Pending) |
$ 91,020 | |
|
Demers, Catherine (McMaster University) The impact of mild cognitive deficits at hospital discharge on self-care in older heart failure patients |
TYPE | 3 Year |
|
New Annual |
$ 97,569 | |
|
Dorian, Paul (St. Michael's Hospital) Studies of the effect of fish oil derived omega-3 Polyunsaturated fatty acids ( EPA and DHA), and omega-6 fatty acids on experimental atrial fibrillation, and mechanisms of their antiarrhythmic effects |
TYPE | 3 Year |
|
New Annual (Pending) |
$ 126,562 | |
|
Egan, Mary (University of Ottawa) Engaging in values activities post stroke |
TYPE | 2 Year |
|
New Annual |
$ 47,287 | |
|
Eikelboom, John W.A. (McMaster University) Thrombotic mechanisms as predictors of Vascular events In non-cardiac Surgery patIents cohOrt evaluatioN (ThromboVISION) |
TYPE | 3 Year |
|
New Annual (Pending) |
$ 128,934 | |
|
Feldman, Ross D. (University of Western Ontario) Determinants of adenylyl cyclase-mediated vascular responses. |
TYPE | 4 Year |
|
Renewal (Pending) |
$ 146,322 | |
|
Feng, Qingping (University of Western Ontario) Heart development in diabetes: role of nitric oxide |
TYPE | 3 Year |
|
New Annual (Pending) |
$ 133,267 | |
|
Feng, Qingping (University of Western Ontario) Rac1 signaling in myocardial TNF-alpha expression in sepsis |
TYPE | 2 Year |
|
New Annual (Pending) |
$ 80,000 | |
|
Funk, Colin D. (Queen's University) Biochemistry and biology of cyclooxygenases |
TYPE | 5 Year |
|
New Annual (Pending) |
$ 134,381 | |
|
Funk, Colin D. (Queen's University) COX-2 pathway and cardiovascular disease |
TYPE | 5 Year |
|
Renewal (Pending) |
$ 115,882 | |
|
Grace, Sherry L. (University Health Network) An RCT of women's adherence to women-only, home-based and traditional cardiac rehabilitation (Cardiac Rehabilitation for Her heart Event Recovery [CR4HER]) |
TYPE | 3 Year |
|
New Annual (Pending) |
$ 108,179 | |
|
Gross, Peter L. (McMaster University) Defining how atorvastatin inhibits platelets |
TYPE | 2 Year |
|
Renewal |
$ 80,000 | |
|
Gula, Lorne J. (University of Western Ontario) Monitoring of Ventricular Rhythm & Exercise - ICD study (MOVE-IT). |
TYPE | 3 Year |
|
New Annual (Pending) |
$ 71,574 | |
|
Hayward, Catherine P. (McMaster University) Molecular cause of profibrinolytic human platelets and leukocytes. |
TYPE | 2 Year |
|
Renewal |
$ 80,000 | |
|
Hayward, Catherine P. (McMaster University) Functions of multimerin 1 as a platelet adhesive protein. |
TYPE | 2 Year |
|
Renewal |
$ 80,000 | |
|
Heckman, George A.W. (McMaster University) Adapting the Canadian cardiovascular society recommendations on heart failure: a consensus-based approach with stakeholder input |
TYPE | 2 Year |
|
New Annual (Pending) |
$ 79,571 | |
|
Hegele, Robert A. (University of Western Ontario) Genomics of hypertriglyceridemia |
TYPE | 5 Year |
|
Renewal |
$ 168,410 | |
|
Heximer, Scott P. (University of Toronto) Defining the molecular pathways through which RGS4 regulates parasympathetic signaling and heart rate control in sinoatrial node myocytes |
TYPE | 5 Year |
|
Renewal (Pending) |
$ 147,955 | |
|
Holden, Rachel M. (Queen's University) Mechanisms of vascular calcification (VC) in a model of chronic kidney disease (CKD) |
TYPE | 3 Year |
|
New Annual (Pending) |
$ 85,855 | |
|
Hou, Sheng T. (University of Ottawa) Investigation of SEMA3A's role in angiogenesis and vascular permeability during stroke recovery |
TYPE | 3 Year |
|
Renewal |
$ 70,916 | |
|
Hough, Margaret R. (Sunnybrook Health Sciences Centre) Cardiac repair and regeneration |
TYPE | 2 Year |
|
Renewal |
$ 79,500 | |
|
Husain, Mansoor (University of Toronto) Molecular studies of cardiac and vascular disease. |
TYPE | 5 Year |
|
Career Investigator |
||
|
Husain, Mansoor (University Health Network) Plasma membrane Ca2+ ATPase 4 isoforms: regulation and role in cardiac and smooth muscle |
TYPE | 3 Year |
|
New Annual (Pending) |
$ 115,230 | |
|
Husain, Mansoor (University Health Network) c-Myb-dependent proliferation & differentiation of vascular smooth muscle cells (VSMC) |
TYPE | 3 Year |
|
New Annual (Pending) |
$ 110,250 | |
|
Husain, Mansoor (University Health Network) The role of glucagon-like peptide-1 in cardiac health and disease |
TYPE | 5 Year |
|
Renewal (Pending) |
$ 140,000 | |
|
Jin, Tianru (University Health Network) A novel mechanism in controlling the expression of ChREBP and lipogenesis |
TYPE | 2 Year |
|
New Annual |
$ 66,759 | |
|
Jones, Nina (University of Guelph) Cell migration pathways in mammalian cardiovascular development |
TYPE | 5 Year |
|
New Annual (Pending) |
$ 97,685 | |
|
Karkouti, Keyvan (University Health Network) Advance targeted transfusion in anemic cardiac surgical patients for kidney protection: a proof of concept pilot study. |
TYPE | 2 Year |
|
New Annual (Pending) |
$ 62,101 | |
|
Keeley, Fred W. (Hospital for Sick Children) Recombinantly expressed elastin-like polypeptides as a novel tool for investigations of the structure, assembly, and the properties of elastin-like materials |
TYPE | 4 Year |
|
Renewal |
$ 129,236 | |
|
Keith, Mary E. (St. Michael's Hospital) A randomized controlled trial of the effect of thiamin supplementation on heart function in ambulatory patients with heart failure |
TYPE | 3 Year |
|
New Annual (Pending) |
$ 84,637 | |
|
Khokha, Rama (University Health Network) Molecular dissection of the distinct functions of TIMP-3 and TIMP-4 in heart disease |
TYPE | 5 Year |
|
Renewal (Pending) |
$ 114,381 | |
|
Kislinger, Thomas (University Health Network) Identification and characterization of cell-surface associated protein in the heart : applications of a novel proteomic strategy |
TYPE | 5 Year |
|
New Annual |
$ 126,785 | |
|
Krahn, Andrew D. (University of Western Ontario) Inherited causes of sudden death: phenotype genotype correlation |
TYPE | 4 Year |
|
Renewal |
$ 168,777 | |
|
Kuebler, Prof. Wolfgang (St. Michael's Hospital) New concept of hypoxic pulmonary vasoconstriction: conducted response via connexin 40. |
TYPE | 3 Year |
|
New Annual (Pending) |
$ 88,605 | |
|
Lagace, Thomas A. (University of Ottawa Heart Institute) Regulation of the PCSK9 binding interaction with LDL receptor |
TYPE | 3 Year |
|
New Annual (Pending) |
$ 76,819 | |
|
Lee, Ting-Yim (Lawson Health Research Institute) Prediction of hemorrhagic transformation of ischemic stroke with CT perfusion derived blood-brain-barrier permeability surface area product |
TYPE | 5 Year |
|
New Annual (Pending) |
$ 90,674 | |
|
Leenen, Frans H.H. (University of Ottawa Heart Institute) Brain mechanisms determining sympathetic hyperactivity and cardiac dysfunction in rats post MI |
TYPE | 5 Year |
|
New Annual (Pending) |
$ 130,922 | |
|
Leong-Poi, Howard M. (St. Michael's Hospital) Role of statins in progenitor cell therapy for chronic ischemia |
TYPE | 2 Year |
|
New Annual (Pending) |
$ 73,400 | |
|
Li, Ren-Ke (University Health Network) Modifying cardiac repair using molecular and cellular interventions |
TYPE | 2 Year |
|
Renewal |
$ 80,000 | |
|
Licht, Christoph P.B. (Hospital for Sick Children) Atypical hemolytic uremic syndrome: a new pathological role for complement and coagulation control in platelets |
TYPE | 3 Year |
|
New Annual |
$ 94,470 | |
|
Linkins, Lori-Ann (McMaster University) Evaluation of a diagnostic strategy for patients with suspected heparin-induced thrombocytopenia (HIT) |
TYPE | 2 Year |
|
Renewal (Pending) |
$ 79,809 | |
|
Liu, Peter P. (University Health Network) Strategies to optimize mobilization, homing and reconstitution therapy in cardiac repair post-infarction |
TYPE | 2 Year |
|
Renewal (Pending) |
$ 80,000 | |
|
MacDonald, John F. (University of Western Ontario) The characterization of non-selective cation channels contributing to delayed cell death following stroke |
TYPE | 5 Year |
|
New Annual (Pending) |
$ 150,343 | |
|
Marcel, Yves L. (University of Ottawa Heart Institute) Low HDL syndrome and the inflamed monocytes |
TYPE | 2 Year |
|
Renewal (Pending) |
$ 80,000 | |
|
Marsden, Philip A. (University of Toronto) Post-transcriptional regulation of endothelial gene expression |
TYPE | 5 Year |
|
Renewal (Pending) |
$ 12,9915 | |
|
Martino, Rosemary (University of Toronto) Psychometric testing of a new scale measuring medical outcomes of dysphagia (MOD) in adult patients with swallowing disorders secondary to stroke |
TYPE | 3 Year |
|
New Annual (Pending) |
$ 165,427 | |
|
McCrindle, Brian W. (Hospital for Sick Children) Increasing physical activity among children with congenital heart defects |
TYPE | 3 Year |
|
Renewal |
$ 176,045 | |
|
McCulloch, Christopher A. (University of Toronto) Role of intercellular adhesions in diabetic cardiomyopathy |
TYPE | 3 Year |
|
New Annual |
$ 94,000 | |
|
McPherson, Ruth (University of Ottawa Heart Institute) Genotype to phenotype: functional analysis of CHD genetic variants |
TYPE | 2 Year |
|
New Annual (Pending) |
$ 79,080 | |
|
Min, Wei-Ping (University of Western Ontario) Preventing heart graft rejection by inhibiting innate and adaptive alloimmunity through gene silencing of toll-like receptors |
TYPE | 2 Year |
|
Renewal |
$ 77,380 | |
|
Nanthakumar, Kumaraswamy (University Health Network) Electrophysiological implications of regenerative therapy |
TYPE | 3 Year |
|
New Annual (Pending) |
$ 89,365 | |
|
Nurse, Colin A. (McMaster University) Functional and anatomical characterization of rat aortic body chemoreceptors |
TYPE | 2 Year |
|
New Annual (Pending) |
$ 75,594 | |
|
Opas, Michal J. (University of Toronto) The role of calreticulin in cardiac remodelling |
TYPE | 2 Year |
|
New Annual (Pending) |
$ 68,338 | |
|
Park, David S. (University of Ottawa) Mechanism of delayed death in stroke |
TYPE | 3 Year |
|
Renewal |
$ 135,639 | |
|
Parkinson, John (Hospital for Sick Children) An interdisciplinary approach to identifying and characterizing polymorphisms in tropoelastin and their role in late onset cardiovascular disease |
TYPE | 3 Year |
|
Renewal |
$ 109,947 | |
|
Peng, Tianqing (London Health Sciences Centre) Targeting mitochondrial redox signaling to prevent myocardial dysfunction in sepsis |
TYPE | 5 Year |
|
Renewal (Pending) |
$ 112,934 | |
|
Prado, Marco A.M. (University of Western Ontario) Decreased cholinergic tone and heart dysfunction |
TYPE | 5 Year |
|
New Annual (Pending) |
$ 126,288 | |
|
Rao, Vivek (University Health Network) EGFL-7, rapamycin and transplant vasculopathy. |
TYPE | 2 Year |
|
Renewal |
$ 60,500 | |
|
Redington, Andrew N. (Hospital for Sick Children) The effect of remote ischemic preconditioning on clinical and genomic responses to open heart surgery in children |
TYPE | 3 Year |
|
New Annual (Pending) |
$ 148,534 | |
|
Reid, Robert D. (University of Ottawa Heart Institute) Efficacy and cost-effectiveness of cost-free pharmacotherapy for smoking cessation for high-risk smokers with cerebrovascular disease |
TYPE | 3 Year |
|
New Annual (Pending) |
$ 258,098 | |
|
Retnakaran, Ravi R. (Mount Sinai Hospital) The early natural history of cardiovascular disease at 4-years postpartum in young women with varying degrees of glucose intolerance in pregnancy |
TYPE | 3 Year |
|
New Annual |
$ 59,836 | |
|
Rocheleau, Jonathan V. (University Health Network) Interaction between vascular endothelial cells and pancreatic beta cells: understanding the role of fibroblast growth factor(FGF) |
TYPE | 3 Year |
|
New Annual (Pending) |
$ 85,450 | |
|
Rodger, Marc A. (Ottawa Health Research Institute) Recurrent venous thromboembolism risk stratification evaluation (REVERSE) : long term follow-up to define if lifelong anticoagulation is required in high risk patients with a first unprovoked venous thromboembolism |
TYPE | 4 Year |
|
New Annual (Pending) |
$ 111,945 | |
|
Ruel, Marc Andre (University of Ottawa Heart Institute) Evaluation of biopolymer delivered EPCs for cardiac repair in a swine model of hibernating myocardium |
TYPE | 2 Year |
|
Renewal (Pending) |
$ 79,536 | |
|
Schlichter, Lyanne C. (University Health Network) Modulating modes of microglial activation to reduce secondary stroke injury |
TYPE | 5 Year |
|
Renewal (Pending) |
$ 128,526 | |
|
Shaughnessy, Stephen G. (McMaster University) Mechanism(s) of low molecular weight heparin-induced bone loss |
TYPE | 2 Year |
|
New Annual (Pending) |
$ 80,000 | |
|
Sheffield, William P. (McMaster University) Transforming hirudin into an activatable, clot-localized thrombin inhibitor |
TYPE | 3 Year |
|
Renewal (Pending) |
$ 103,190 | |
|
Simmons, Craig A. (University of Toronto) The role of C-type natriuretic peptide in cardiac valve fibrosis |
TYPE | 3 Year |
|
New Annual |
$ 88,000 | |
|
So, Derek Y.F. (University of Ottawa Heart Institute) Obstructive sleep apnea as a risk factor for clopidogrel unresponsiveness in patients undergoing percutaneous coronary intervention: prevalence, mechanisms and possible influence on clinical outcomes |
TYPE | 2 Year |
|
New Annual (Pending) |
$ 79,100 | |
|
Sorisky, Alexander (Ottawa Health Research Institute) MAPping adipose tissue malfunction in obesity: macrophages, adipose cells, and PDGF |
TYPE | 5 Year |
|
New Annual (Pending) |
$ 135,537 | |
|
St. Lawrence, Keith S. (London Health Sciences Centre) Oxygen consumption is an early predictor of brain damage following hypoxia-ischemia |
TYPE | 3 Year |
|
New Annual (Pending) |
$ 88,730 | |
|
Stagljar, Igor (University of Toronto) Functional analysis of the interactome of the human B-adrenergic receptors |
TYPE | 3 Year |
|
New Annual |
$ 94,090 | |
|
Stefanovic, Bojana (Sunnybrook Health Sciences Centre) Biophysics of functional MRI |
TYPE | 3 Year |
|
New Annual (Pending) |
$ 65,885 | |
|
Steinman, David A. (University of Toronto) Hemodynamic factors in vascular disease: from bench to bedside. |
TYPE | 5 Year |
|
Career Investigator |
||
|
Steinman, David A. (University of Toronto) Flow in the common carotid artery is not fully-developed: implications for studies of atherosclerosis |
TYPE | 2 Year |
|
New Annual (Pending) |
$ 47,023 | |
|
Sugita, Shuzo (University Health Network) The roles of CAPS1 in catecholamine secretion |
TYPE | 2 Year |
|
Renewal (Pending) |
$ 76,850 | |
|
Suskin, Neville G. (Lawson Health Research Institute) Comprehensive cardiac rehabilitation programming for patients following transient ischemic attack(extension) |
TYPE | 3 Year |
|
Renewal |
$ 156,884 | |
|
Suuronen, Erik J. (University of Ottawa Heart Institute) Recruitment of endogenous circulating progenitor cells for cardiac regeneration using enhanced tissue-engineered biomatrices |
TYPE | 3 Year |
|
Renewal (Pending) |
$ 125,232 | |
|
Tesson, Frederique (University of Ottawa Heart Institute) Cell nucleus and dilated cardiomyopathy. |
TYPE | 3 Year |
|
New Annual (Pending) |
$ 94,310 | |
|
Tsushima, Robert G. (York University) SNARE protein regulation of cardiac ion channels and ANF secretion. |
TYPE | 5 Year |
|
Career Investigator |
||
|
Tsushima, Robert G. (York University) SNARE protein regulation of cardiac ion channels and ANF secretion |
TYPE | 4 Year |
|
Renewal (Pending) |
$ 100,000 | |
|
Tulloch, Heather E. (University of Ottawa Heart Institute) Interventions to reduce cardiovascular disease: ""real world"" effectiveness of combined pharmacotherapy and behavioral counselling for smoking cessation. |
TYPE | 4 Year |
|
New Annual (Pending) |
$ 258,244 | |
|
Verma, Subodh (St. Michael's Hospital) Elucidating the in vivo role of adiponectin in inflammation: a biochemical and pharmacological approach |
TYPE | 3 Year |
|
New Annual (Pending) |
$ 64,685 | |
|
Verma, Subodh (St. Michael's Hospital) Role of the tumor suppressor Gene BRCA1 in adverse cardiac remodeling |
TYPE | 2 Year |
|
New Annual (Pending) |
$ 80,000 | |
|
Verma, Subodh (St. Michael's Hospital) Neuregulin-1 as a novel treatment for endothelial dysfunction and atherosclerosis |
TYPE | 2 Year |
|
New Annual |
$ 80,000 | |
|
Ween, Jon E. (Baycrest) Refinement of a point-of-care, electronic testing tool for the longitudinal stroke assessments |
TYPE | 2 Year |
|
New Annual |
$ 80,000 | |
|
Wen, Xiao-Yan (University Health Network) Roles of novel lpdl and lpdlr phospholipases in platelet activation and thrombosis |
TYPE | 3 Year |
|
Renewal (Pending) |
$ 113,126 | |
|
Werstuck, Geoffrey H. (McMaster University) Mechanisms by which diabetes mellitus promote accelerated atherosclerosis |
TYPE | 2 Year |
|
New Annual (Pending) |
$ 79,600 | |
|
Yang, Burton B. (Sunnybrook Health Sciences Centre) MicroRNA miR-378 regulates self renewal and angiogenesis |
TYPE | 3 Year |
|
New Annual (Pending) |
$ 103,720 | |
|
Yang, Guangdong (Lakehead University) Regulation of cystathionine gamma-lyase expression in vascular smooth muscle cells |
TYPE | 2 Year |
|
New Annual (Pending) |
$ 73,700 | |
|
Zandstra, Peter W. (University of Toronto) Interrogating the cardiomyogenic hierarchy to optimize cardiovascular cell therapy |
TYPE | 5 Year |
|
Renewal |
$ 143,700 | |
|
Zhang, Shetuan (Queen's University) Control of cell surface channel density by potassium as a novel mechanism for hERG regulation. |
TYPE | 5 Year |
|
Renewal (Pending) |
$ 140,172 | |
|
Zhang, Zhu-Xu (Lawson Health Research Institute) Therapeutic potential and mechanism of double-negative regulatory T (DN-Treg) cells mediated tolerance in heart transplantation |
TYPE | 3 Year |
|
Renewal (Pending) |
$ 100,980 |