Heart and Stroke Foundation of Canada Research Programs - 2008 HSFO Grants-in-Aid and Career Investigator Competition Results

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Heart and Stroke Foundation of Ontario

Results of September 2007 Grant-in-Aid (GIA) and Career Investigator Competitions

The Heart and Stroke Foundation of Ontario is pleased to announce the results of the September 2007 Grant-in-Aid and Career Investigator competitions.

The GIA competition
Of the 218 applications received, the Foundation was able to offer funding to 118 Ontario investigators, representing a first-year investment of $10.9 million, a 30% increase over the September, 2006 competition. This growth is a result of the Foundation’s strategic directive to reward excellence more richly, and offer higher levels of funding to very highly rated GIA applications. The Foundation’s total investment offer over 5 years is $33.7 million, a 43% increase over last year.

The competition results posted below are to be considered preliminary only. An official letter will be sent to all applicants the week of March 24, 2008, along with the budget / funding details and rankings.

The list provides the name of the principal investigator, institution, title, type of grant, first-year operating budget, term of the grant, and whether any condition has been placed on approval of the grant. For those awards identified as "pending", funding is encumbered until additional information is provided. This will be addressed in the letters to applicants noted above. This list is for information only.

Career Investigator awards do not have first year amounts, however the standard stipend applies.

The Foundation requests that applicants do not write or telephone with any enquiries before receiving the award letters.

Adams, Michael A. (Queen's University) Antihypertensive treatment strategies in the management of sexual dysfunction	TYPE	3 Year
	Renewal (Pending)	$95,533
Anand, Sonia (McMaster University) Understanding genetic associations with myocardial infarction in multiethnic populations	TYPE	2 Year
	New Annual	$46,747
Austin, Peter C. (Institute for Clinical Evaluative Sciences) Statistical methods for cardiovascular research	TYPE	5 Year
	Career Investigator
Austin, Richard C. (McMaster University) Contributions of the unfolded protein response pathway to adipogenesis and obesity	TYPE	3 Year
	New Annual	$79,234
Backx, Peter H. (University of Toronto) Transcriptional regulation of cardiac transient outward K+ currents and function in heart	TYPE	5 Year
	Renewal (Pending)	$149,714
Bai, Donglin (University of Western Ontario) The role of connexin43 in cardiac function	TYPE	3 Year
	New Annual (Pending)	$123,465
Beanlands, Rob S. B. (University of Ottawa Heart Institute) Metabolism, energetics and neurohormonal signaling and their response to therapy in dysfunctional myocardium	TYPE	5 Year
	Career Investigator
Beanlands, Rob S. B. (University of Ottawa Heart Institute) Effects of continuous positive airway pressure therapy on myocardial energetics and sympathetic nerve function in patients with heart failure and obstructive sleep apnea	TYPE	2 Year
	Renewal (Pending)	$125,159
Benazon, Nili R. (Centre for Addiction & Mental Health) Correlates of women's compliance with exercise prescriptions during and following cardiac rehabilitation	TYPE	2 Year
	Renewal (Pending)	$109,868
Birnie, David H. (University of Ottawa Heart Institute) Long-term effects of cardiac resynchronization therapy on LV remodeling and ventricular arrhythmia: the reverse remodeling study	TYPE	2 Year
	New Annual (Pending)	$20,100
Boughner, Derek R. (University of Western Ontario) Early image-based diagnosis of aortic valve sclerosis in a rabbit model	TYPE	2 Year
	Renewal (Pending)	$80,000
Cattral, Mark S. (Toronto General Hospital, UHN) Role of immedate dendritic cell precursors in allograft regection and tolerance	TYPE	3 Year
	New Annual (Pending)	$76,694
Chakrabarti, Subrata (University of Western Ontario) Vasoactive and cardioactive factors in diabetic heart disease	TYPE	2 Year
	New Annual	$74,400
Chan, Anthony K.C. (McMaster University) Carbohydrate variation effects in the protein C pathway during development	TYPE	3 Year
	New Annual (Pending)	$76,239
Chen, Hsiao-Huei (University of Ottawa) Mechanisms to reduce injury and improve recovery from stroke	TYPE	3 Year
	New Annual (Pending)	$101,442
Chidiac, Peter (University of Western Ontario) Impact of RGS proteins on cardiovascular function	TYPE	5 Year
	Career Investigator
Chidiac, Peter (University of Western Ontario) Role of RGS2 in cardiovascular and metabolic function	TYPE	2 Year
	New Annual (Pending)	$79,150
Ciriello, John (University of Western Ontario) Leptin links obstuctive sleep apnea, obesity and hypertension	TYPE	3 Year
	New Annual (Pending)	$111,275
Coles, John G. (Hospital for Sick Children) Integrin-linked kinase (ILK) promotes compensated cardiac hypertrophy	TYPE	2 Year
	New Annual (Pending)	$78,300
Coles, John G. (Hospital for Sick Children) Defective cell signaling in tetralogy of fallot (TF)	TYPE	2 Year
	Renewal (Pending)	$79,017
Connelly, Philip W. (St. Michael's Hospital) Studies of the lactonase activity of paraoxonase 1 - and HDL associated enzyme of relevance to cardiovascular disease	TYPE	3 Year
	Renewal (Pending)	$77,300
Copeland, John W. (University of Ottawa) Role of formin proteins in shear stress-induced cytoskeletal remodeling in endothelial cells	TYPE	5 Year
	Renewal	$103,950
Cregan, Sean P. (Robarts Research Institute) Mechanisms of P53 induced neuronal apoptosis	TYPE	3 Year
	New Annual (Pending)	$78,553
DaSilva, Jean N. (University of Ottawa Heart Institute) Altered noradrenergic signaling transduction in the development of cardiac dysfunction in Diabetes: role of glycemic therapy	TYPE	2 Year
	New Annual	$78,481
Dawson, John F. (University of Guelph) Expression and characterization of human cardiac actin mutants linked to hypertrophic and dilated cardiomyopathies	TYPE	3 Year
	New Annual (Pending)	$78,555
Dick, Alexander J. (Sunnybrook Health Science Centre) Endothelial progenitor cell modification to improve left ventricular function post myocardial infarction	TYPE	3 Year
	Renewal	$76,877
Drangova, Maria (Robarts Research Institute) Dynamic micro-CT for pre-clinical cardiac imaging	TYPE	3 Year
	Renewal	$113,071
Emili, Andrew (University of Toronto) Mechanistic investigation of microRNA-mediated regulation of dilated cardiomyopathy (DCM)	TYPE	3 Year
	New Annual	$96,378
Fehlings, Michael G. (Toronto Western Hospital, UHN) The ischemic axon: cross-talk with myelin in K+ channel terms	TYPE	3 Year
	Renewal	$84,389
Ferguson, Stephen G. (Robarts Research Institute) Molecular regulation of G protein-coupled receptor signal transduction, desensitization and resensitization	TYPE	5 Year
	Career Investigator
Floras, John S. (Mount Sinai Hospital) Neural regulation of the circulation in human heart failure and hypertension	TYPE	3 Year
	New Annual	$128,257
Floras, John S. (Mount Sinai Hospital) Central regulation of autonomic cardiovascular function in human heart failure and sleep apnea	TYPE	3 Year
	New Annual (Pending)	$72,621
Fowler, Robert A. (Sunnybrook Health Science Centre) E-PROTECT: prospective economic analysis in the prophylaxis for thromboembolism in critical care trial	TYPE	3 Year
	New Annual (Pending)	$76,076
Gagnon, France (University of Toronto) Genome-wide search for oligogenes in factor V leiden thrombophilia	TYPE	3 Year
	Renewal	$107,355
Giacca, Adria (University of Toronto) Vasculoprotective effect of insulin in vivo	TYPE	3 Year
	Renewal	$76,668
Grace, Sherry L. (York University) An RCT of women's adherence to women-only, home-based and traditional cardiac rehabilitation (CR4HER)	TYPE	3 Year
	New Annual (Pending)	$101,379
Graham, Simon J. (Baycrest Centre for Geriatric Care) Further development of fMRI technology applied to stroke recovery	TYPE	2 Year
	New Annual	$79,406
Gramolini, Anthony O. (University of Toronto) Investigation of phospholamban mutations, sarcoplasmic reticulum calcium defects, and dilated cardiomyopathy	TYPE	3 Year
	Renewal (Pending)	$93,400
Grant, David R. (Toronto General Hospital, UHN) fgl2/FGL2 and xenograft transplantation	TYPE	3 Year
	Renewal (Pending)	$88,600
Grover, Ashok K. (McMaster University) Caloxins: novel inhibitors of plasma membrane calcium pumps	TYPE	3 Year
	Renewal	$76,928
Hamilton, Robert M. (Hospital for Sick Children) Intercalated disc protein expression in arrhythmogenic right ventricular cardiomyopathy	TYPE	2 Year
	New Annual (Pending)	$72,100
Hammond, James R. (University of Western Ontario) Role of nucleoside/nucleobase transporters in the regulation of the vascular effects of adenosine and its metabolites	TYPE	3 Year
	Renewal	$75,900
Hess, David A. (Robarts Research Institute) Cellular constituents and paracrine pathways that mediate functional vascular regeneration	TYPE	3 Year
	New Annual (Pending)	$102,201
Hinek, Aleksander (Hospital for Sick Children) Elastin and elastin receptor as crucial factors modulationg cellular funtions in cardiovascular development and diseases	TYPE	5 Year
	Renewal	$118,060
Holdsworth, David W. (Robarts Research Institute) Investigation of flow in the stenosed carotid bifurcation	TYPE	5 Year
	Renewal (Pending)	$117,236
Igdoura, Suleiman A. (McMaster University) Molecular impact of sialidase on atherosclerosis in transgenic mice	TYPE	2 Year
	Renewal (Pending)	$80,000
Iscoe, Steven D. (Queen's University) Inspiratory occlusion-induced cardiac dysfunction in rats and mice	TYPE	2 Year
	New Annual (Pending)	$72,189
Kearon, Clive (McMaster University) Optimizing treatment and diagnosis of venous thromboembolism	TYPE	5 Year
	Career Investigator
Khan, Nadia A. (University of British Columbia) Sex and ethnic differences in stroke prognosis and quality of care	TYPE	2 Year
	New Annual (Pending)	$21,450
Koschinsky, Marlys L. (Queen's University) Modulation of the TAFI pathway in health and disease: mechanistic analysis of the regulation of TAFI gene expression in hepatic and extrahepatic cells	TYPE	4 Year
	New Annual	$113,328
Krahn, Andrew D. (University of Western Ontario) Inherited arrhythmias: clinical and genetic assessment of primary electrical disease	TYPE	5 Year
	Career Investigator
Lanctot, Krista L. (Sunnybrook Health Science Centre) The role of cytokine-serotonin interactions in post-stroke depression and cognitive symptoms	TYPE	3 Year
	Renewal (Pending)	$97,113
Lee, Douglas S. (Institute for Clinical Evaluative Sciences) Emergent care and outcomes of acute heart failure	TYPE	2 Year
	New Annual (Pending)	$79,900
Lee, Jonathan M. (University of Ottawa) The role of elongation factor eEF1A2 in obesity	TYPE	3 Year
	New Annual (Pending)	$69,024
Lee, Robert M.K.W. (McMaster University) Alterations in hypertensive arteries	TYPE	2 Year
	Renewal	$78,280
Leenen, Frans H.H. (University of Ottawa Heart Institute) RAS blockade and sympathetic activity in humans post MI	TYPE	3 Year
	New Annual	$106,381
Lewis, Gary F. (Toronto General Hospital, UHN) Determining the mechanisms of the dyslipidemia of insulin resistant states and Type 2 diabetes	TYPE	2.5 Year
	Career Investigator
Lewis, Gary F. (Toronto General Hospital, UHN) The role of C-reactive protein (CRP) in modulating insulin action and insulin secretion	TYPE	3 Year
	New Annual (Pending)	$83,000
Leytin, Valery (St. Michael's Hospital) Mitochondrial control of platelet apoptosis	TYPE	5 Year
	Renewal (Pending)	$94,954
Liaw, Patricia C.Y. (McMaster University) Studies of the endothelial cell protein C receptor (EPCR)	TYPE	3 Year
	New Annual (Pending)	$121,160
Lillicrap, David (Queen's University) Gain-of-function mutants affecting the glycoprotein Ib/von Willebrand factor interaction: Potential novel antithrombotic molecules	TYPE	5 Year
	New Annual (Pending)	$138,494
Linkins, Lori-Ann (McMaster University) Selective D-dimer testing for diagnosis of deep vein thrombosis	TYPE	1 Year
	Renewal (Pending)	$145,200
Liu, Fang (Centre for Addiction & Mental Health) The role of protein-protein interaction in neurological/neurophsyciatric diseases	TYPE	5 Year
	Career Investigator
Liu, Fang (Centre for Addiction & Mental Health) Functional and molecular characterization of protein-protein interaction between AMPA receptors and GAPDH (Glyceraldehyde-3-phosphate Dehydrogenase)	TYPE	5 Year
	Renewal	$95,300
Logan, Alexander G. (Mount Sinai Hospital) Role of extracellular fluid volume in inducing obstructive sleep apnea in refractory hypertension	TYPE	2 Year
	New Annual	$51,020
Mak, Susanna (Mount Sinai Hospital) Studies of sympathetic nervous system activation in patients with pulmonary arterial hypertension	TYPE	3 Year
	New Annual	$57,596
Mak, Susanna (Mount Sinai Hospital) Sex determinants of left ventricular mechanical performance in humans with and without heart failure	TYPE	3 Year
	New Annual	$64,126
Marcel, Yves L. (University of Ottawa Heart Institute) Apolipoprotein A-I lipidation and HDL genesis	TYPE	5 Year
	New Annual (Pending)	$136,792
Marsden, Philip A. (University of Toronto) The human nitric oxide synthase genes: relevance to disease	TYPE	2.5 Year
	Career Investigator
Martino, Tami A. (University of Toronto) Circadian control of cardiac remodeling	TYPE	3 Year
	New Annual (Pending)	$77,700
Maurice, Donald H. (Queen's University) Phosphodiesterases in arteries	TYPE	3 Year
	Renewal (Pending)	$91,695
McBride, Heidi M. (University of Ottawa Heart Institute) Mechanism and function of mitochondrial derived vesicles	TYPE	5 Year
	Renewal	$122,333
McDonald, Sarah D. (McMaster University) The CAP study: cardiovascular disease after preeclampsia	TYPE	2 Year
	New Annual (Pending)	$161,352
Mehta, Sanjay (London Health Sciences Centre) Complex regulation of microvascular endothelial cell function in sepsis	TYPE	5 Year
	Renewal	$118,905
Mequanint, Kibret (University of Western Ontario) Vascular smooth muscle cell phenotype switching and elastin synthesis in 3D tissue engineered coronary artery substitutes	TYPE	2 Year
	New Annual	$79,800
Morshead, Cindi M. (University of Toronto) The development of drug and cell delivery systems for use in cell based therapies to treat stroke	TYPE	3 Year
	New Annual (Pending)	$153,110
Neilipovitz, David T. (The Ottawa Hospital) Short term atorvastatin regime for vascular surgery (STAR VaS) Study	TYPE	2 Year
	New Annual (Pending)	$78,214
Nemer, Mona (University of Ottawa) Mechanisms of TBX5 action in the heart	TYPE	3 Year
	New Annual (Pending)	$118,196
Ng, Dominic S.K. (St. Michael's Hospital) Regulation of lipids, insulin action and cell stress in LCAT deficient mice	TYPE	3 Year
	New Annual (Pending)	$107,530
Ni, Heyu (St. Michael's Hospital) Novel mechanisms of platelet aggregation: unveiling new roles of non-classical beta3 integrin ligands in thrombosis and hemostasis	TYPE	4 Year
	Renewal (Pending)	$120,901
O'Brien, Edward R. (University of Ottawa Heart Institute) Extracellular and intracellular vascular roles of HSP27: an estrogen receptor beta associated heat shock protein	TYPE	3 Year
	Renewal (Pending)	$77,400
O'Donnell, Martin J. (McMaster University) Interstroke (Pilot): Importance of conventional and emerging risk factors for stroke in different regions of the world and in different ethnic groups (Lipids, Glucose, and Sodium)	TYPE	2 Year
	New Annual	$112,160
Ooi, Teik Chye (Ottawa Health Research Institute) Human studies on gender differences in PCSK9 function in lipoprotein metabolism	TYPE	2 Year
	New Annual (Pending)	$95,400
Park, David S. (University of Ottawa) Oxidative stress and ischemic death	TYPE	5 Year
	Renewal (Pending)	$118,600
Parker, John D. (Mount Sinai Hospital) Development of a new technique to assess endothelial function: flow mediated constriction	TYPE	5 Year
	New Annual (Pending)	$130,366
Parker, Thomas G. (St. Michael's Hospital) EF-hand proteins, S100A1 and A6, in cardiovascular pathophysiology	TYPE	5 Year
	New Annual (Pending)	$115,150
Peng, Tianqing (London Health Sciences Centre) Role of calpain activation in myocardial dysfunction in sepsis	TYPE	3 Year
	New Annual (Pending)	$122,162
Pickering, J. Geoffrey (London Health Sciences Centre) Role of smooth muscle cells in vascular disease	TYPE	2.5 Year
	Career Investigator
Pilote, Louise (McGill University) Genesis praxy: Gender and sex determinants of cardiovascular disease from bench to beyond in premature acute coronary syndrome	TYPE	3 Year
	New Annual (Pending)	$45,524
Rose, David R. (Ontario Cancer Institute, UHN) The molecular basis for starch digestion in the intestine: Human maltase-glucoamylase and sucrase-isomaltase	TYPE	5 Year
	New Annual	$82,604
Ross, Robert M.J. (Queen's University) Acute and chronic exercise as treatment strategies for erectile dysfunction in sedentary obese men	TYPE	2 Year
	New Annual (Pending)	$79,603
Rui, Tao (Lawson Health Research Institute) Role of HMGB1 in ischemia/reperfusion-induced myocardial injury	TYPE	3 Year
	New Annual (Pending)	$95,208
Schlichter, Lyanne C. (Toronto Western Hospital, UHN) Pathophysiology and inflammation after intracerebral hemorrhage	TYPE	5 Year
	Renewal	$143,007
Scott, Ian C. (Hospital for Sick Children) Genetic and cellular analysis of the role of agtrl1b, a known cardioprotective factor, in myocardial progenitor development	TYPE	3 Year
	New Annual (Pending)	$120,155
Shah, Baiju R. (Institute for Clinical Evaluative Sciences) Diabetes care and outcomes for people with Chinese and South Asian origins	TYPE	3 Year
	New Annual (Pending)	$103,369
Sheffield, William P. (McMaster University) Exploring engineered serpins as potential antithrombotic agents	TYPE	4 Year
	Renewal (Pending)	$93,967
Shoemaker, J. Kevin (University of Western Ontario) Plasticity of cortical-cardiovascular interactions in vascular disease	TYPE	3 Year
	Renewal (Pending)	$79,756
Sled, John G. (Hospital for Sick Children) Three-dimensional quantification of the placental vasculature: relationship with normal and abnormal fetal growth and hemodynamics	TYPE	2 Year
	Renewal	$75,626
Spafford, J. David (University of Waterloo) Structure-function analyses of drug interactions with L-type calcium channels	TYPE	3 Year
	New Annual	$76,248
Sparks, Daniel L. (University of Ottawa Heart Institute) The role of HDL in triglyceride metabolism	TYPE	3 Year
	Renewal	$80,000
Stanford, William L. (University of Toronto) Developmental and functional characterization of novel regulators of thrombopoiesis identified by mouse mutagenesis	TYPE	2 Year
	New Annual (Pending)	$103,309
Tang, Damu (McMaster University) Characterization of a novel insig binding protein (INsigBP1)	TYPE	3 Year
	New Annual	$81,500
Timmons, Brian W. (McMaster University) A pilot study of circulating progenitor cells in children and adolescents: relationship with habitual physical activity, aerobic fitness and body composition	TYPE	1 Year
	New Annual	$32,134
Tobe, Sheldon W. (Sunnybrook Health Science Centre) Harmony study (Hypertension analysis of stress reduction using mindfulness meditation and yoga)	TYPE	3 Year
	New Annual	$75,627
Touyz, Rhian M. (Ottawa Health Research Institute) TRPM7 signaling through lipid rafts in vascular smooth muscle cells - implications in hypertension	TYPE	3 Year
	Renewal (Pending)	$108,905
Trigatti, Bernardo L. (McMaster University) Molecular mechanisms by which HDL contributes to atherosclerotic plaque regression	TYPE	2 Year
	New Annual (Pending)	$99,750
Tsushima, Robert G. (York University) Cell signalling ion myocardial ischemia preconditioning	TYPE	3 Year
	New Annual (Pending)	$79,700
Tyml, Karel (Lawson Health Research Institute) Hypoxia/reoxygenation, systemic inflammation, and vascular cell coupling	TYPE	2 Year
	Renewal (Pending)	$79,346
Van Arsdell, Glen S. (Hospital for Sick Children) Selective generation of cardiac progenitor cells and cardiomyocytes from mouse cells	TYPE	2 Year
	New Annual (Pending)	$67,340
Van Huysse, James W. (University of Ottawa Heart Institute) Roles of the brain Na, K-ATPase alpha isoforms in the regulation of blood pressure	TYPE	3 Year
	New Annual	$76,949
von Harsdorf, Rudiger (Toronto General Hospital, UHN) Evaluation of p21CIP1/WAF1 protein transduction as a novel therapeutic approach in heart failure	TYPE	3 Year
	New Annual (Pending)	$80,000
Walley, Keith R. (University of British Columbia) Genetic determinants of neurocognitive dysfunction following cardiopulmonary bypass	TYPE	3 Year
	Renewal (Pending)	$85,328
Wang, Hao (University of Western Ontario) Soluble CD83 based therapy in cardiac allograft tolerance	TYPE	3 Year
	Renewal (Pending)	$79,967
Wang, Rui (Lakehead University) CSE deficiency-related hypertension development	TYPE	3 Year
	New Annual (Pending)	$79,740
Weitz, Jeffrey I. (McMaster University) Impact of gamma' fibrinogen on clot formation and clot lysis at sites of plaque rupture	TYPE	5 Year
	Renewal (Pending)	$112,150
Weksberg, Rosanna (Hospital for Sick Children) Developmental programming of intrauterine growth restriction and adult cardiovascular risk	TYPE	3 Year
	New Annual (Pending)	$79,700
Wells, James W. (University of Toronto) Nature of the signalling complex between cardiac muscarinic receptors and G proteins	TYPE	3 Year
	Renewal	$80,830
Wells, Philip S. (Ottawa Health Research Institute) Development and validation of clinical prediction rules for bleeding for patients on anticoagulant therapy for venous thromboembolism	TYPE	5 Year
	New Annual (Pending)	$195,550
Wells, R. Glenn (University of Ottawa Heart Institute) Increasing certainty in micro-SPECT/CT	TYPE	2 Year
	New Annual	$78,555
White, James A. (London Health Sciences Centre) Multi-modality imaging assessment for pacing interventions in heart failure (MAPIT-HF)	TYPE	3 Year
	New Annual (Pending)	$103,338
Whitman, Stewart C. (University of Ottawa Heart Institute) The role of the innate immune system in atherosclerosis: Further defining the role of NKT cells, interferon-gamma and IL-4 in the disease process	TYPE	3 Year
	Renewal (Pending)	$98,800
Wiper-Bergeron, Nadine L. (University of Ottawa) The inhibition of adipocyte differentiation by retinoic acid: A role for C/EBPbeta displacement	TYPE	2 Year
	New Annual (Pending)	$71,468
Wisenberg, Gerald (London Health Sciences Centre) Evaluation in a large animal model of the use of Akt enhanced endothelial progenitor cells for augmenting healing after myocardial infarction	TYPE	2 Year
	Renewal	$78,883
Yang, Burton B. (Sunnybrook Health Science Centre) Roles of miR-17-5p in endothelial wound healing and angiogenesis	TYPE	3 Year
	New Annual (Pending)	$82,060
Yee, Raymond (London Health Sciences Centre) His bundle and para-hisian pacing: Acute and chronic benefits	TYPE	2 Year
	New Annual (Pending)	$74,819
Yeung, Rae S.M. (Hospital for Sick Children) Towards a better understanding of kawasaki disease	TYPE	3 Year
	Renewal (Pending)	$79,725
Zha, Xiaohui (Ottawa Health Research Institute) Signal transduction pathways that regulate ABCA1-mediated cholesterol efflux	TYPE	2 Year
	Renewal	$74,300
Zhang, Wandong (National Reasearch Council) Modulation of MMP9 expression induced by cerebral ischemia and reperfusion to reduce blood-brain barrier permeability and brain damage in ischemic stroke	TYPE	3 Year
	New Annual	$56,000

Last Updated ( Tuesday, 03 March 2009 )