Heart and Stroke Foundation of Ontario

September 1999 Competition - Confirmation of
Budget Commitment for the 2nd Year of Funding

For grants that were awarded in the September 1999 competition, the Heart and Stroke Foundation of Ontario is pleased to announce confirmation of the 2nd year budget commitment on multi-year Grants-in-Aid and Personnel Awards. These grants took effect July 1, 2000. An official letter will also be sent to all applicants shortly. For those awards identified as “pending”, funding is encumbered until additional information is provided. With regard to projects that have been identified as being “applied” or “clinically oriented”, in keeping with the Foundation’s Progress Report policy, funding is encumbered pending the May 15, 2001 Progress Report.

September 2000 Competition Funding Decisions
The funding decisions for the September 2000 competition will be announced by the end of February on the national website www.hsf.ca/research.

Adeli, Khosrow (Hospital for Sick Children)

Mechanisms and Regulation of Apolipoprotein B Degradation

TYPE 2nd YEAR AWARD
Renewal $102,041

Alhesayen, Abdurrahman, O (Mount Sinai Hospital)

Endothelin Kinetics in Human Congestive Heart Failure

TYPE 2nd YEAR AWARD
Fellowship $51,600

Andrew, Maureen (Hamilton Civic Hospitals Research Centre)

Fibrinolytic mechanisms and treatment of TE in the young

TYPE 2nd YEAR AWARD
Renewal $64,780

Andrew, Maureen (The Hospital for Sick Children)

Fibrinolytic mechanisms and treatment of thromboembolic disease in the young

TYPE 2nd YEAR AWARD
Career Investigator $76,250

Arnold, J. Malcolm (London Health Sciences Centre,)

Vascular Responses in Heart Failure

TYPE 2nd YEAR AWARD
Renewal $99,066

Arthur, Heather M. (McMaster University)

Reducing Anxiety in Patients Awaiting Elective Cardiac Catheterization

TYPE 2nd YEAR AWARD
New Annual
"pending"
$39,141

Baker, Robert Roy (University of Toronto)

The Metabolism of Platelet activating factor in brain

TYPE 2nd YEAR AWARD
Renewal $65,594

Bennett, Brian M. (Queen's University)

Mechanisms of action and tolerance development to organic nitrates

TYPE 2nd YEAR AWARD
Renewal $63,131

Bonen, Arend (University of Waterloo)

Regulation of FAT/CD36 and fatty acid transport in the heart

TYPE 2nd YEAR AWARD
Renewal $64,980

Brown, Arthur (The John P. Robarts Research Institute)

Endocardial Cushion Defects in DphA3 Mutant Mice

TYPE 2nd YEAR AWARD
New Annual $73,849

Bulman, Dennis E. (Ottawa Hospital Research Institute)

Genetic Linkage Analysis in Congenital Bicuspid Aortic Valve

TYPE 2nd YEAR AWARD
New Annual $68,050

Capone, John P. (McMaster University)

Function and mechanisms of action of peroxisome proliferator-activated receptors

TYPE 2nd YEAR AWARD
Renewal $132,239

Chretien, Michel (Loeb Research Institute)

Proprotein Convertases: Implication for Management of Restenosis

TYPE 2nd YEAR AWARD
New Annual $72,941

Cole, David E.C. (University of Toronto)

Homocysteine and Cardiac Transplantation

TYPE 2nd YEAR AWARD
Renewal $65,701

Coles, John G. (Hospital for Sick Children)

Xenogenic Cardiomyocyte Transplantation

TYPE 2nd YEAR AWARD
New Annual $65,244

Courtman, David W. (St. Michael's Hospital)

Arterial Anastomotic Remodeling

TYPE 2nd YEAR AWARD
New Annual $66,639

Cox, Peter (Hospital for Sick Children)

Heparin Bonded Catheters and Thrombosis in Pediatric Critical Care Patients

TYPE 2nd YEAR AWARD
New Annual
"pending"
$25,891

Cybulsky, Myron I. (Toronto General Hospital Research Inst)

Regional activation of NF-kB signal transduction in arterial endothelium: role in atherogenesis

TYPE 2nd YEAR AWARD
New Annual $91,290

D'Souza, Sudhir (London Health Sciences Centre)

Dopamine receptors in renal tubule epithelial cells

TYPE 2nd YEAR AWARD
New Annual $61,085

Durkin, Jon P. (National Research Council of Canada)

Mechanism of MK-801 Pre-conditioning and Neuroprotection

TYPE 2nd YEAR AWARD
Renewal $56,825

Ellis, Christopher (University of Western Ontario)

Regulation of Microvascular Oxygen

TYPE 2nd YEAR AWARD
Renewal $59,917

Feldman, Ross D. (The John P. Robarts Research Institute)

Tyrosine kinase-mediated sensitization of adenylyl cyclase activation

TYPE 2nd YEAR AWARD
Renewal $64,235

Ferguson, Alastair (Queen's University)

Intrinsic conductances and protection from excitotoxic cell death

TYPE 2nd YEAR AWARD
Renewal $61,341

Fliss, Henry (University of Ottawa)

Myocardial reperfusion injury: the role of apoptosis

TYPE 2nd YEAR AWARD
Renewal $66,725

Ginsberg, Jeffrey S. (McMaster University Medical Centre)

Management of the Post Phlebitic Syndrome

TYPE 2nd YEAR AWARD
New Annual
"pending"
$126,270

Graham, Charles H. (Queen's University)

Oxygen-regulated gene expression in preeclamptic hypertension

TYPE 2nd YEAR AWARD
Renewal $83,490

Grant, David (Toronto General Hospital)

Prevention of Delayed Cardiac Xenograft Rejection by Modulation of the Potent FGL2 Prothbrombinase Gene

TYPE 2nd YEAR AWARD
New Annual $67,711

Gros, Robert (Toronto General Hospital)

Regulated expression of PMCA isoforms in arterial smooth muscle cells of transgenic mice

TYPE 2nd YEAR AWARD
Fellowship $38,950

Guha, Abhijit (Toronto Western Hospital)

Neoangiogenesis in Cerebral Ischemia

TYPE 2nd YEAR AWARD
Renewal $93,300

Hakim, Antoine M. (University of Ottawa)

Role of XIAP in calcium ion homeostasis

TYPE 2nd YEAR AWARD
New Annual $62,000

Haslam, Richard J. (McMaster University)

Mechanisms of cyclic nucleotide action

TYPE 2nd YEAR AWARD
Renewal $67,602

Hayward, Catherine P. (McMaster University)

Characterization of Multimerin as a Novel, Platelet and Vascular Adhesive Protein

TYPE 2nd YEAR AWARD
Renewal $78,193

Hayward, Catherine P. (McMaster University)

Serine Proteases in Normal and Pathologic Platelets

TYPE 2nd YEAR AWARD
New Annual $80,863

Hayward, Catherine P. (McMaster University)

Investigations of Novel Secretory Proteins in Platelets and Vascular Endothelium

TYPE 2nd YEAR AWARD
Career Investigator $76,250

Hegele, Robert A. (Robarts Research Institute)

Genetic determinants of coronary heart disease

TYPE 2nd YEAR AWARD
Career Investigator $76,250

Hinek, Aleksander (Hospital for Sick Children)

Role of Elastin receptor in Pathobiology of Arterial Thickening

TYPE 2nd YEAR AWARD
New Annual $74,094

Holdsworth, David W. (J. P. Robarts Research Institute)

Investigation of flow in the stenosed carotid bifurcation

TYPE 2nd YEAR AWARD
Renewal $55,301

Hornberger, Lisa (The Hospital for Sick Children)

B1 Integrins and the IFG2-IGF1 Receptor system in Fetal Cardiac Myocyte Proliferation: Regulatory Role for the Nuclear Transcription Factor, Sp1

TYPE 2nd YEAR AWARD
New Annual $58,985

Hu, Bin (Loeb Health Research Institute)

Cellular Mechanism Underlying Mannitol-Based Neuroprotection

TYPE 2nd YEAR AWARD
Renewal $65,977

Huff, Murray W. (John P. Robarts Research Institute)

Regulation of Apolipoprotein B Metabolism

TYPE 2nd YEAR AWARD
Renewal $114,392

Hughson, Richard L. (University of Waterloo)

Integrative Cerebrovascular and Cardiovascular Responses: Effects of Age and Gender

TYPE 2nd YEAR AWARD
New Annual $36,549

Husain, Mansoor (The Toronto General Hospital)

Conditional over-expression of PMCA sioforms in arterial SMC of transgenic mice

TYPE 2nd YEAR AWARD
New Annual $65,433

Irvine, Jane (The Toronto Hospital)

Home Exercise Training for Patients with Intermittent Claudication

TYPE 2nd YEAR AWARD
New Annual
"pending"
$137,550

Karmazyn, Morris (University of Western Ontario)

Endothelin/nitric oxide interaction in the regulation of cardiac function in health and disease

TYPE 2nd YEAR AWARD
Renewal $82,218

Katzmarzyk, Peter T. (York University)

Genetics of Blood Pressure and Body Fatness in Canada: Cross-Trait and Longitudinal Analyses

TYPE 2nd YEAR AWARD
New Annual $23,000

Kawaja, Michael David (Queen's University)

Perturbing Sympathetic Hyperinnervation Associated with the Spontaneously Hypertensive Rat Phenotype

TYPE 2nd YEAR AWARD
Renewal $65,256

Kearon, Clive (Henderson General Hospital)

Fixed Dose unfractionated heparin for initial treatment of venous thromboembolism

TYPE 2nd YEAR AWARD
Renewal $109,029

Kelton, John G. (McMaster University)

Platelet-Mediated Acute Thrombocytopenic Disorders

TYPE 2nd YEAR AWARD
Renewal $158,977

Koschinsky, Marlys L. (Queen's University)

The Structural Basis of Lipoprotein (a) Pathogenicity

TYPE 2nd YEAR AWARD
Renewal $78,709

Lafrenie, Robert M. (Northeastern Ont. Regional Cancer Ctre.)

Integrin-dependent signal transduction in monocytes

TYPE 2nd YEAR AWARD
New Annual $50,562

Langille, B. Lowell (The Toronto Hospital)

Cell Biology of Atherosclerosis

TYPE 2nd YEAR AWARD
Program Grant $154,195

Lee, Robert M.K. (McMaster University)

Alterations in hypertensive arteries

TYPE 2nd YEAR AWARD
Renewal $85,762

Lillicrap, David (Queen's University)

The Influence of Genotype and Environment on von Willebrand Factor

TYPE 2nd YEAR AWARD
Renewal $87,214

Lillicrap, David (Queen's University)

The influence of genotype and environment on von Willebrand factor gene expression

TYPE 2nd YEAR AWARD
Career Investigator $76,250

Liu, Peter P. (The Toronto General Hospital)

Immunological Mechanisms of Chlamydia Induced Cardiovascular Injury

TYPE 2nd YEAR AWARD
New Annual $101,197

MacDonald, John F. (University of Toronto)

New Targets for ischemic Cell Death

TYPE 2nd YEAR AWARD
New Annual $69,350

MacManus, John P. (National Research Council)

E2F1 transcription factor and GAPDH promote neuronal death following cerebral ischemia

TYPE 2nd YEAR AWARD
Renewal $59,241

Mak, Alan S. (Queen's University)

The roles of Rho-GTPases in vascular smooth muscle cell migration

TYPE 2nd YEAR AWARD
Renewal $77,861

Mantle, Ross E. (Loeb Health Research Institute)

Functional characterization of hypothalamic and medullary synaptic inputs to spinal sympathetic preganglionic neurons

TYPE 2nd YEAR AWARD
Fellowship $51,600

McKelvie, Robert S. (Hamilton Health Sciences Corporation)

Assessing the Value of Screening for Asymptomatic Left Ventricular Dysfunction

TYPE 2nd YEAR AWARD
New Annual
"pending"
$71,134

Megeney, Lynn A. (Ottawa General Hospital Research Inst.)

Defining Molecular Basis for Post-natal Growth of the Myocardium

TYPE 2nd YEAR AWARD
New Annual $75,174

Merino, Jose (London Health Science Centre)

Advanced imaging of plaque instability in asymptomatic carotid stenosis

TYPE 2nd YEAR AWARD
Fellowship $25,800

Mitchell, Lesley G. (The Hospital for Sick Children Res. Ins.)

Predictors of thrombosis in patients with SLE and APLA: A prospective cohort study

TYPE 2nd YEAR AWARD
New Annual
"pending"
$68,729

Monge, Juan C. (St. Michael's Hospital)

Regulation of the Expression of the Endothelin Receptors

TYPE 2nd YEAR AWARD
New Annual $68,760

Morley, Paul (NRC University of Ottawa)

Mechanisms of Ischemic Preconditioning

TYPE 2nd YEAR AWARD
Renewal $58,201

Morris, Catherine E. (Loeb Health Research Institute)

Surface area Regulation: sublethal ischemia and neuronal repair

TYPE 2nd YEAR AWARD
Renewal $47,854

Nag, Sukriti (The Toronto Hospital - Western Division)

Regulation of Cerebrovascular Homeostasis and Repair by Angiogenic Factors

TYPE 2nd YEAR AWARD
New Annual $64,333

Nakatsu, Kanji (Queen's University)

Effects of nitrovasodilators, NO and CO on blood vessel function

TYPE 2nd YEAR AWARD
New Annual $57,518

Nesheim, Michael E. (Queen's University)

The Activation of TAFI and the Properties of TAFIa

TYPE 2nd YEAR AWARD
Renewal $77,075

Nesheim, Michael E. (Queen's University)

Collaborative Studies of Hemostatisis, Fibrinolysis and Vascular cell growth and function

TYPE 2nd YEAR AWARD
Program Grant $126,131

Nichol, Graham (Loeb Health Research Institute)

Clinical Outcomes Related to Economics for Congestive Heart Failure

TYPE 2nd YEAR AWARD
New Annual
"pending"
$73,543

Noble, Earl (University of Western Ontario)

Gender specific regulation of myocardial HSP 72: Molecular and functional implications

TYPE 2nd YEAR AWARD
New Annual $31,442

O'Brien, Edward R. (University of Ottawa Heart Institute)

Estrogen and Atherosclerosis

TYPE 2nd YEAR AWARD
Renewal $67,339

O'Brodovich, Hugh (Hospital for Sick Children)

Pulmonary Edema's Effect on Epithelial Ion and Fluid Transport

TYPE 2nd YEAR AWARD
New Annual $75,760

Ofosu, Frederick A. (McMaster University)

Platelet-derived serine protease and platelet activation

TYPE 2nd YEAR AWARD
New Annual $58,709

Parker, John D. (Mount Sinai Hospital)

Endothelin-1 kinetics in human heart failure

TYPE 2nd YEAR AWARD
New Annual $74,448

Pickering, J. Geoffrey (London Health Sciences Centre)

Control of Smooth Muscle Cell Differentiation

TYPE 2nd YEAR AWARD
Renewal $77,060

Pratt, M. Christine (University of Ottawa)

Gender differences in vascular estrogen response: role of ERB

TYPE 2nd YEAR AWARD
Renewal $73,038

Renaud, Leo P. (Ottawa Hospital)

Suprachiasmatic Nucleus Efferents

TYPE 2nd YEAR AWARD
Renewal $56,485

Ross, Gregory M. (Queen's University)

A Zinc-Induced Loss of Neurotrophin Activity and Neuronal Death

TYPE 2nd YEAR AWARD
Renewal $49,448

Serrador, Jorge M. (Hebrew Rehabilitation Ctr. for the Aged)

Altered Baroreflex Modulation Effects on Cerebrovascular Regulation in Ageing and Disease

TYPE 2nd YEAR AWARD
Fellowship $38,950

Shin, Seon H. (Queen's University)

Mechanisms of ascorbate-induced brain cell death - a new stroke model

TYPE 2nd YEAR AWARD
New Annual $57,755

Sibbald, William J. (Sunnybrook & Women's College Health Ctre)

Mechanism and Consequences of Myocardial Tolerance in Sepsis

TYPE 2nd YEAR AWARD
Renewal $60,054

Slack, Ruth (University of Ottawa)

The Role of Bax and APAF1 in p53 Induced Neuronal Cell Death

TYPE 2nd YEAR AWARD
Renewal $59,842

Sole, Michael J. (The Toronto General Hospital)

Molecular Genetics of Hypertrophic Cardiomyopathy

TYPE 2nd YEAR AWARD
Renewal $165,057

Sorisky, Alexander (Loeb Health Research Institute)

PI 3-kinase-dependent signalling in the preadipocyte: differentiation, apoptosis, and obesity

TYPE 2nd YEAR AWARD
Career Investigator $76,250

Sparks, Daniel L. (University of Ottawa Heart Institute)

HDL Structure and Function

TYPE 2nd YEAR AWARD
Career Investigator $76,250

Spence, J. David (John P. Robarts Research Institute)

Determinants of carotid atherosclerosis: 1. Chlamydia and mannose binding lectin

TYPE 2nd YEAR AWARD
Renewal $72,369

Stanimirovic, Danica B. (Inst. for Biological Sciences)

Transcriptional Regulation of Inflammatory Genes in Brain Endothelial Cells and Astrocytes by Hypoxia/Ischemia

TYPE 2nd YEAR AWARD
Renewal $56,541

Steiner, George (The Toronto General Hospital)

Triglyceride-rich lipoprotein metabolism in insulin resistance and type 2 diabetes

TYPE 2nd YEAR AWARD
Renewal $87,652

Tsushima, Robert G. (University of Toronto)

Regulation of Cardiac Calcium-Activated Nonselective Cation Channels

TYPE 2nd YEAR AWARD
New Annual $58,348

Tu, Jack V. (Inst. for Clinical Evaluative Sciences)

Carotid Endarterectomy Health Services Research Program

TYPE 2nd YEAR AWARD
Renewal $59,902

Verdi, Joseph M. (John P. Robarts Research Institute)

PITS: A Novel Growth Arrest Gene in Sympathetic Neurogenesis

TYPE 2nd YEAR AWARD
New Annual $61,255

Wan, Qi (Toronto Western Research Institute)

Molecular mechanisms of AMPA receptor-mediated excitotoxicity

TYPE 2nd YEAR AWARD
New Annual $69,680

Warkentin, Theodore E. (Hamilton Health Sciences Corporation)

Heparin-induced thrombocytopenia

TYPE 2nd YEAR AWARD
Renewal $61,397

Weaver, Lynne C. (John P. Robarts Research Institute)

Cardiovascular control after spinal cord injury

TYPE 2nd YEAR AWARD
Renewal $89,519

Wells, James W. (University of Toronto)

Effects of G Proteins on Cardiac Muscarinic Receptors

TYPE 2nd YEAR AWARD
Renewal $76,677

Wells, Philip S. (University of Ottawa)

The Bioped Study

TYPE 2nd YEAR AWARD
Renewal $41,640

Worton, Ronald D. (Ottawa General Hospital)

Regulation of Dystrophin Expression in Cardiac & Skeletal Muscle

TYPE 2nd YEAR AWARD
New Annual $54,968

Yao, Zemin (University of Ottawa Heart Institute)

Functional analysis of HSPG ginding domains of human hepatic lipase

TYPE 2nd YEAR AWARD
New Annual $45,474

Yeung, Rae S-M (Hospital for Sick Children)

Kawasaki Disease: How a mouse becomes the vehicle of choice for studying coronary arteritis

TYPE 2nd YEAR AWARD
New Annual $66,577

Yusuf, Salim (Hamilton General Hospital)

Inter-Heart

TYPE 2nd YEAR AWARD
New Annual
"pending"
$99,142

Last Updated ( Wednesday, 06 June 2007 )