2016/17 Grant-In-Aid Grantees

Anderson, Geoffrey (Institute for Clinical Evaluative Sciences)
The impact and management of cardiovascular disease in Ontario women diagnosed with early stage breast cancer
Ballermann, Barbara (University of Alberta)
Glomerular Capillary Integrity in the face of Hypertension: CLIC-dependent control of the actin cytoskeleton
Barber, Philip (University of Calgary)
Predementia Neuroimaging of TIA (PREVENT) Study
Beaulieu, Christian (University of Alberta)
Timing Stroke in Wake-up Patients with Unknown Onset Using Sodium Magnetic Resonance Imaging at 3T
Bedard, Karen (Dalhousie University)
Using patient derived cells to study heritable arrhythmogenic right ventricular cardiomyopathy
Bergeron, Richard (Ottawa Hospital Research Institute)
Glycine and Brain Ischemia
Bhatia, Rajan (Women’s College Hospital)
The relationship between low value cardiac testing, health utilization and quality of cardiovascular care
Bolz, Steffen-Sebastian (University of Toronto)
Correcting CFTR dysfunction normalizes microvascular reactivity and improves neurological outcome in subarachnoid hemorrhage
Bourque, Charles (McGill University Health Center Research Institute)
Role of osmoreceptor gain in salt-sensitive hypertension
Brambati, Simona Maria (Institut universitaire de gériatrie de Montréal)
Co-PI: Marcotte, Karine
Dynamics of language recovery in post-stroke aphasia: A longitudinal neuroimaging study
Cayabyab, Francisco (University of Saskatchewan)
Neurotoxicity through prolonged adenosine A1 receptor activation: Cellular, synaptic plasticity, and behavioral implications in the rat hippocampus
Chakrabarti, Subrata* (University of Western Ontario)
Vasoactive and cardioactive factors in diabetic heart disease
*CP Has Heart Cardiovascular Award 2016 Recipient
Chalifour, Lorraine (Lady Davis Institute for Medical Research)
Bisphenols, phthalates and recovery post-myocardial infarction
Chan, Vincent (University of Ottawa Heart Institute)
Randomized trial of mitral valve repair with leaflet resection versus leaflet preservation– Multicenter Study from the Canadian Mitral Researchers (CAMRA)
Chen, Joyce (Sunnybrook Health Sciences Centre)
Co-PI: Levin, Mindy
Towards a personalized approach to stroke motor recovery with transcranial direct current stimulation
Chen, S.R. Wayne (University of Calgary)
Molecular Basis of Cardiac Ryanodine Receptor Luminal Ca2+ Activation and Its Role in Arrhythmias
Childs, Sarah (University of Calgary)
Genetic mechanisms of blood vessel patterning into a branched network
Colbourne, Frederick (University of Alberta)
Use of therapeutic hypothermia for intracerebral hemorrhagic stroke
Corbett, Dale (University of Ottawa)
Co-PI: Dancause, Numa
Removing the brakes on post-stroke behavioural recovery
Corrales-Medina , Vicente* (Ottawa Hospital Research Institute)
Co-PI: Dwivedi, Girish
Vascular inflammation after acute pneumonia as measured by 18FDG-PET/CT scan
*CP Has Heart Cardiovascular Award 2016 Recipient
Coutts, Shelagh (University of Calgary)
Co-PI: Hill, Michael
TEMPO-2 – A randomized controlled trial of TNK-tPA versus standard of care for minor ischemic stroke with proven occlusion
Davenport, Margie (University of Alberta)
Co-PI: Steinback, Craig
Blood pressure regulation during hypertensive pregnancies
de Azeredo Coutinho, Thais (University of Ottawa Heart Institute)
Predictors of Disease Progression in Thoracic Aorta Aneurysms: Role of Arterial Stiffness and Hemodynamics
Dehaes, Mathieu (Hôpital Sainte Justine)
Bedside monitoring of pre- and postoperative brain metabolic needs in neonatal d-transposition of the great arteries
Dolinsky, Vernon (University of Manitoba)
The regulation of cardiac mitochondrial homeostasis in heart failure by SIRT3
Duhamel, Todd (University of Manitoba)
Examining SERCA2a acetylation in the diabetic heart
Dyck, Jason (University of Alberta)
The Role of Adipose Tissue Inflammation and Lipolysis in the Pathogenesis of Heart Failure
Eskes, Gail (Dalhousie University)
The behavioural and neural mechanisms in prism adaptation treatment for spatial neglect
Figeys, Daniel (University of Ottawa)
Molecular Mechanisms of PCSK9 Regulation
Fiset, Céline (Institut de Cardiologie de Montréal)
Influence of pregnancy on the automaticity of the heart
Fouad, Karim (University of Alberta)
Promoting spinal plasticity to enhance recovery following stroke
Friedberg, Mark (Hospital for Sick Children)
Septal insertion injury mediates adverse ventricular-ventricular interaction in right ventricular pressure and volume loading
Gallagher, Anne (Hôpital Sainte Justine)
Co-PI: Carmant, Lionel
Impact of early intervention on neurodevelopmental outcome in CHD
Garg, Amit (Lawson Health Research Institute)
Major cardiovascular outcomes with personalized dialYsate TEMPerature (MY TEMP): A registry-based cluster randomized control trial
Gros, Robert (University of Western Ontario)
Co-PI: Prado, Marco
The Protective Role of the Cholinergic System in the Heart
Hammond, James (University of Alberta)
SLC29A4 in cardiovascular function and dysfunction
Henderson, Melanie (Hôpital Sainte Justine)
Determinants of Cardiovascular Disease among Youth with Type 1 Diabetes - a Pilot Study
Hoppmann, Christiane (University of British Columbia)
Linked Lives- A Couples Approach to Health Behaviors Post Stroke
Husain, Mansoor (University Health Network)
Mechanisms of action of the cardioprotective metabolite GLP-1(28-36)
Ikura, Mitsuhiko (University Health Network)
Mechanistic studies on store-operated calcium entry in Heart and Stroke
Jenne, Craig (University of Calgary)
The Role of Platelet Activation in Pathogen-induced Coagulopathy
Jones, Peter (University of Manitoba)
Evaluating the anti-hypertensive properties of whole hemp seed protein and hemp seed protein hydrolysate derived bioactive peptide consumption
Kapral, Moira (Institute for Clinical Evaluative Sciences)
Measuring and improving stroke care in rural Ontario
Kauppinen, Tiina (University of Manitoba)
The role of PARP-1 as a modulator of microglial responses in ischemic stroke
Krahn, Andrew (University of British Columbia)
CASPER: Canadian Genetic Heart Rhythm Network
Krassioukov, Andrei (University of British Columbia)
When are blood vessels “ready to rupture”? Cerebrovascular health following spinal cord injury: from animal models to clinical practice
Kuebler, Wolfgang (St. Michael's Hospital)
HMGB1 promotes pulmonary hypertension by triggering inflammation and autoimmunity
Larrivee, Bruno (Hôpital Maisonneuve-Rosemont)
Targeting BMP signalling for the prevention of vascular retinal dysfunctions
Lee, Warren (St. Michael's Hospital)
Molecular mechanisms of LDL transcytosis
Leong-Poi, Howard (St. Michael's Hospital)
Ultrasound-Targeted MicroRNA Therapy for Aortic Aneurysm
Luo, Honglin (St. Paul's Hospital)
Molecular chaperones in viral cardiomyopathy
MacLeod, Kathleen (University of British Columbia)
ROCK2 and obesity cardiomyopathy: mechanisms contributing to mitochondrial and contractile dysfunction
Marsden, Philip (St. Michael's Hospital)
Post-transcriptional regulation of endothelial gene expression
McManus, Alison (University of British Columbia)
Prolonged sitting and brain health in healthy weight and obese children
Mehta, Sanjay (London Health Sciences Centre)
Mechanisms and Regulation of Microvascular Endothelial Cell Apoptosis in Sepsis
Menon, Carlo (Simon Fraser University)
Does haptic feedback via bimanual elbow robotic orthoses promote cortical function and recovery from stroke
Michelakis, Evangelos (University of Alberta)
Metabolic Modulation of the Human Pulmonary Hypertension Lung
Mourad, Walid (Centre hospitalier de l'université de Montréal)
Novel functions of CD154 in atherothrombosis
Musselman, Kristin (University Health Network)
Functional electrical stimulation to improve upper extremity function in young children with perinatal stroke: a proof of concept study
Nattel, Stanley (Montreal Heart Institute)
Nuclear-Delimited Signaling in Arrhythmogenic Cardiac Remodeling
Noiseux, Nicolas (Centre hospitalier de l'université de Montréal)
Co-PI: Roy, Denis-Claude
Optimizing cell therapy for cardiovascular disease: a translational approach to the next generation clinical trials
Nuyt, Anne Monique (Hôpital Sainte Justine)
Endothelial progenitor cells impairment and activation of the renin angiotensin system as mechanism for cardiovascular disease after preterm birth: a translational approach
Parkash, Ratika (Nova Scotia Health Authority)
Canadian Community Utilization of Stroke Prevention Study – Focusing on Emergency Department Care (C-CUSP ED)
Plane, Frances (University of Alberta)
Calcium-activated potassium channels as targets for novel vascular drugs
Poulin, Marc (University of Calgary)
Role of Intermittent Hypoxia in the Pathogenesis of Obstructive Sleep apnea
Radisic, Milica (University of Toronto)
Mobilizing epicardial cells for enhanced integration of human cardiac patches
Rayner, Katey (University of Ottawa Heart Institute)
Exosomal microRNAs as mediators of cell-cell communication in atherosclerosis
Reinhardt, Dieter (McGill University)
Role of plasma and cellular fibronectin in blood vessel function
Rhodes, Ryan (University of Victoria)
Promoting Family Physical Activity through Habit Formation: A randomized trial
Rodrigues, Brian (University of British Columbia)
Endothelial cell-cardiomyocyte crosstalk in diabetic cardiomyopathy
Salbach, Nancy (University of Toronto)
Co-PI: Kelloway, Linda
Increasing access to community-based task-oriented exercise programs through healthcare-recreation partnerships to improve function post-stroke: Feasibility of a 2-group RCT protocol
Sapieha, Przemyslaw (Mike) (Hôpital Maisonneuve-Rosemont)
Modulation of Neuronal Stress for Vascular Regeneration
Sapp, John (Nova Scotia Health Authority)
Ventricular Tachycardia Antiarrhythmics or AblatioN In Structural Heart Disease 2 Pilot Study
Schmitz, Norbert (McGill University)
Poor sleep and mental health: independent or overlapping risk factors for heart diseases?  A community based study in Quebec
Scott, Ian (Hospital for Sick Children)
Dissecting the gene regulatory network of cardiac lineage specification and regeneration
Servant, Marc (Université de Montréal)
Studying the involvement of IkappaB kinase (IKK)beta in vascular remodeling events
Simpson, Jeremy (University of Guelph)
Co-PI: Brunt, Keith
Reduced Infarct Size and Preserved Cardiac Function by a Novel Reactive Pharmacological Intervention After Infarction
Steinman, David (University of Toronto)
Co-PI: Mendes Pereira, Vitor
Hemodynamic Predictors of Cerebral Aneurysm Wall Vulnerability
Stewart, Alexandre (University of Ottawa Heart Institute)
Mechanisms of coronary artery calcification risk conferred by 9p21.3 genetic variants
Thiel, Alexander (Lady Davis Institute for Medical Research)
Co-PI: Ostry, David
Robot-assisted modulation of post-stroke motor-network connectivity: from basic science to clinical application
Tomczak, Corey (University of Saskatchewan)
Co-PI: Paterson, David (Ian)
EVADE: Early Versus Standard Access CarDiac Rehabilitation to Counter Ventricular RemodEling Post-MI
Trigatti, Bernardo (McMaster University)
Targeting interleukin-15 to reduced experimental atherosclerosis in mice
Tymianski, Michael (University Health Network)
Developing the “EpiPen” of Acute Stroke and Stroke Recovery
Verma, Atul (St. Michael's Hospital)
Co-PI: Ha, Andrew
Evaluation of "real-world" clinical and economical outcomes of catheter-based atrial fibrillation ablation: Insights from a prospective, population-based registry
Wang, Jing (Ottawa Hospital Research Institute)
Targeting the aPKC-CBP pathway for neurovascular regeneration after stroke related brain injury
Weitz, Jeffrey (McMaster University)
Prevention of Clotting on Mechanical Heart Valves
Whitlock, Richard (McMaster University)
Co-PI: Connolly, Stuart
Left Atrial Appendage Study (LAAOS) III
Wijeysundera, Harindra (Sunnybrook Health Sciences Centre)
Improving Triage and Informing Capacity Needs for Patients with Severe Aortic Stenosis undergoing Transcatheter Aortic Valve Implantation (TAVI): a Pan- Canadian Evaluation
Woo, Minna (Toronto General Hospital Research Institute)
Molecular Dissection of the Role of NAFLD in Atherosclerosis
Wu, Lily (Laurentian University)
The mechanisms for endogenous fructose accumulation and the related vascular complications
Yang, Decheng (St. Paul's Hospital)
Role of translation initiation factor DAP5 in viral myocarditis
Young, Howard (University of Alberta)
Mechanisms of SERCA Dysregulation in Dilated Cardiomyopathy
Zhang, Dawei (University of Alberta)
Molecular mechanism and physiological roles of MT1-MMP-mediated down regulation of LDL receptor