2014/2015 Grant-in-Aid Grantees

Advani, Andrew (St. Michael's Hospital)
HDAC6 in cardiorenal disease.
Ahmed, Sofia (University of Calgary)
Vitamin D supplementation and cardiac autonomic tone in hemodialysis patients: a blinded, randomized placebo-controlled trial.
Allen, Bruce (Institut de Cardiologie de Montréal)
MAP Kinase-Activated Protein Kinases (MKs) mediate distinct detrimental effects of p38 MAP kinase activation in heart.
Andrew, R. David (Queen's University)
Higher brain susceptibility and lower brain resiliency to ischemic injury.
Barber, Philip (University of Calgary)
Recanalization following Endovascular treatment and imaging of PErfusion, Regional inFarction and atrophy to Understand Stroke Evolution (REPERFUSE).
Birnie, David (University of Ottawa Heart Institute)
Co-PI: Essebag, Vidal
BRUISE CONTROL-2: A randomized controlled trial to compare Continued versus Interrupted Dabigatran at the time of device surgery, in patients at high risk of stroke.
Bonnet, Sébastien (Institut universitaire de cardiologie et de pneumologie de Québec)
Role for DNA damage signalling in Pulmonary Arterial Hypertension.
Bousette, Nicolas (Montreal Heart Institute)
The Protective role of Perilipin-2 in Diabetic Cardiomyopathy.
Braam, Branko (University of Alberta)
Co-PI: Cupples, Willam
Renal venous pressure, renal function and experimental heart failure.
Butcher, Ken (University of Alberta)
The Intracerebral Hemorrhage Acutely Decreasing Arterial Pressure Trial II.
Chauhan, Vijay (University Health Network)
Characterizing focal electrical sources and substrate in human atrial fibrillation.
Clee, Susanne (University of British Columbia)
Identification of novel genes affecting body weight.
Coles, John (Hospital for Sick Children)
Co-PI: Maynes, Jason
Rescue of disrupted mechanotransduction as a new therapeutic strategy in human dilated cardiomyopathy.
Cunningham, Charles (Sunnybrook Health Sciences Centre)
Metabolic Imaging of the Hypertrophic Heart.
Danckert, James (University of Waterloo)
Co-PI: Ferber, Susanne
Working memory in spatial neglect: developing a novel theory and rehabilitation program.
Davis, Darryl (University of Ottawa Heart Institute)
Strategies to reverse the effect of hyperglycemia on cardiac stem cells.
Douketis, Jim (McMaster University)
Perioperative New Oral Anticoagulant Study.
Dowlatshahi, Dar (Ottawa Hospital Research Institute)
Co-PI: Chakraborty, Santanu
Predicting intracerebral hemorrhage expansion using the dynamic CT-angiography spot sign.
Drangova, Maria (University of Western Ontario)
Dual energy micro-CT for 3D angiography and cardiovascular histology.
Drucker, Daniel (Samuel Lunenfeld Research Institute of Mount Sinai Hospital)
Cardiovascular biology of dipeptidyl peptidase-4.
Dumont, Dan (Sunnybrook Health Sciences Centre)
Examination of the novel angiopoietin peptide mimetic vasculotide as a treatment for atherosclerosis and ischemia.
Ezekowitz, Justin (University of Alberta)
Febbraio, Maria (University of Alberta)
Periodontal Disease Mechanisms in Atherosclerosis.
Fedida, David (University of British Columbia)
Identification and characterization of molecular interactions between the subunits of the cardiac repolarizing current, IKs, studied using unnatural amino acid mutagenesis and mass spectrometry.
Finestone, Hillel (Elisabeth Bruyère Hospital)
Co-PI: Sveistrup, Heidi
Does virtual reality exercise improve sitting balance ability and function after stroke?
Gramolini, Anthony (University of Toronto)
Phospholamban mutations, sarcoplasmic reticulum calcium defects and cardiomyopathy.
Hamel, Edith (Montreal Neurological Institute)
The cellular basis of neurovascular coupling in the cerebral cortex.
Hamilton, Jill (Hospital for Sick Children)
Cardiometabolic Risk, Obesity and the Microbiome: Development Over the First Two Years of Life in Children Exposed to Gestational Diabetes in Utero.
Hatch, Grant (University of Manitoba)
Regulation of cardiolipin biosynthesis in the heart.
Hoodless, Pamela (BC Cancer Agency)
Regulatory Networks in Heart Valve Formation.
Huff, Murray (University of Western Ontario)
Regulation of dyslipidemia and insulin resistance by flavonoids: Relationship to atherosclerosis.
Janssen, Ian (Queen's University)
The Active Play Study.
Johri, Amer (Queen's University)
Effect of Carnitine Supplementation on Progression of Carotid Plaque in the Metabolic Syndrome (ECoM Study).
Karsan, Aly (BC Cancer Agency)
Mechanisms of vascular development.
Kassiri, Zamaneh (University of Alberta)
Role of TNF-alpha Converting Enzyme (TACE) in Heart Disease.
Kassiri, Zamaneh (University of Alberta)
Paradoxical role of matric metaloproteinase-2 in aortic aneurysm.
Kirshenbaum, Lorrie (University of Manitoba)
Mechanisms of P53 Mediated Cell Death in the Heart.
Ko, Dennis (Institute for Clinical Evaluative Sciences)
Co-PI: Jackevicius, Cynthia
Comparative Effectiveness of Cardiac Drugs Post-Myocardial Infarction.
Krahn, Andrew (University of British Columbia)
National Long QT Syndrome Registry and BioBank.
Le Gal, Gregoire (Ottawa Hospital Research Institute)
Clinical predictors for venous thromboembolism in patients with a history of Thrombosis.
Levin, Mindy (Jewish Rehabilitation Hospital)
Co-PI: Feldman, Anatol
Corticospinal contribution to spasticity and disordered motor control.
Li, Ren-Ke (University Health Network)
Co-PI: Weisel, Richard
Feasibility of a Conductive Polymer Biomaterial to Resynchronize the Infarcted Heart.
Mathieu, Patrick (Institut de cardiologie de Québec)
Inhibition of ectonucleotide pyrophosphatase /phosphodiesterase-1 with a novel quinazolin-derived compound in order to prevent the progression of aortic stenosis.
Nemer, Mona (University of Ottawa)
Transcription networks in cardiac hypertrophy.
Nemer, Mona (University of Ottawa)
Mechanisms of TBX5 action in the heart.
Parker, Thomas (St. Michael's Hospital)
S100A1 and A6 proteins in pulmonary vascular pathophysiology: intracellular, extracellular, and cell-lineage specific mechanisms of action.
Proctor, Spencer (University of Alberta)
Mechanisms that promote remnant lipoprotein retention in arterial tissue during atherogenesis and insulin resistance.
Rand, Margaret (Hospital for Sick Children)
The procoagulant surface of activated platelets: Development and persistence in vitro and in vivo.
Ravandi, Amir (St. Boniface General Hospital Research Centre)
Role of oxidized phospholipids in myocardial ischemia and reperfusion injury.
Reid, Robert (University of Ottawa Heart Institute)
Co-PI: Grace, Sherry
Ecologically Optimizing Exercise Maintenance in Men and Women Post-Cardiac Rehabilitation: A Randomized Controlled Trial of Efficacy with Economics (ECO-PCR).
Roy, Eric (University of Waterloo)
Co-PI: Black, Sandra
Neuropsychological profiles and neuroanatomic correlates of limb apraxia.
Saposnik, Gustavo (St. Michael's Hospital)
Co-PI: Bayley, Mark
Efficacy of Virtual Reality Exercises using Wii gaming technology in STroke Rehabilitation: A multicentre randomized clinical trial (EVREST multicentre).
Scott, Ian (Hospital for Sick Children)
Live analysis of CCM mechanism and progression in a zebrafish CCM3 model.
Sebire, Guillaume (Université de Sherbrooke)
Rôle de la réponse inflammatoire maternofoetale dans la physiopathologie des accidents vasculaires cérébraux (AVC) périnatals.
Slack, Ruth (University of Ottawa)
Regulation of Opa1 to maintain mitochondrial energy metabolism and survival after stroke.
Sorisky, Alexander (Ottawa Hospital Research Institute)
Adipose progenitor cell responses to nutrient stress and macrophages.
Stetefeld, Joerg (University of Manitoba)
Rhodocetin- A snake venom lectin with dual platelet surface receptor binding profiles.
Storey, Kenneth (Carleton University)
Suspended animation: hypometabolic hearts in a model of primate torpor.
Sykes, Brian (University of Alberta)
Co-PI: Hwang, Peter
Development of Calcium Sensitizers That Target Troponin.
Timmons, Brian (McMaster University)
Cardiovascular Health in children with a chronic inflAMmatory condition: role of Physical activity, fItness, and inflammatiON: The CHAMPION Study.
Tuana, Balwant (University of Ottawa)
The role of E2F6 in dilated cardiomyopathy.
Vasconcelos, Sara (University Health Network)
Arterio-venous specification during adult neovascularization.
Vohl, Marie-Claude (Université Laval)
A study of genetic and epigenetic factors influencing obesity-related metabolic complications.
Waisman, David (Dalhousie University)
Defining the physiological function of S100A10 with the S100A10 knockout mouse.
Wells, James (University of Toronto)
Nature of the Signalling Complex between Cardiac Muscarinic Receptors and G Proteins.
Yan, Andrew (St. Michael's Hospital)
Co-PI: Wald, Ron
Impact of In-centre Nocturnal Hemodialysis on Cardiac Remodeling in End-Stage Renal Disease: A Long-term Follow-up Study.
Zandstra, Peter (University of Toronto)
Accelerating the development of regenerative biologics for myocardial infarction using functional human microtissues.